Zobrazeno 1 - 10
of 48
pro vyhledávání: '"L. Meitzler"'
Autor:
Jiamo Lu, Guojian Jiang, Yongzhong Wu, Smitha Antony, Jennifer L Meitzler, Agnes Juhasz, Han Liu, Krishnendu Roy, Hala Makhlouf, Rodrigo Chuaqui, Donna Butcher, Mariam M Konaté, James H Doroshow
Publikováno v:
PLoS ONE, Vol 15, Iss 5, p e0233208 (2020)
To facilitate functional investigation of the role of NADPH oxidase 1 (NOX1) and associated reactive oxygen species in cancer cell signaling, we report herein the development and characterization of a novel mouse monoclonal antibody that specifically
Externí odkaz:
https://doaj.org/article/ebb8d7dabc614df08b60c032e03783fa
Autor:
Jennifer L. Meitzler, Hala R. Makhlouf, Smitha Antony, Yongzhong Wu, Donna Butcher, Guojian Jiang, Agnes Juhasz, Jiamo Lu, Iris Dahan, Pidder Jansen-Dürr, Haymo Pircher, Ajay M. Shah, Krishnendu Roy, James H. Doroshow
Publikováno v:
Redox Biology, Vol 13, Iss C, Pp 182-195 (2017)
NADPH oxidase 4 (NOX4) is a redox active, membrane-associated protein that contributes to genomic instability, redox signaling, and radiation sensitivity in human cancers based on its capacity to generate H2O2 constitutively. Most studies of NOX4 in
Externí odkaz:
https://doaj.org/article/203b8e09d2b54f679af386b93069e9e0
Autor:
Stephen L. Wang, Yongzhong Wu, Mariam Konaté, Jiamo Lu, Smitha Antony, Jennifer L. Meitzler, Guojian Jiang, Iris Dahan, Agnes Juhasz, Becky Diebold, Krishnendu Roy, James H. Doroshow
Pro-inflammatory cytokines upregulate the expression of the H2O2-producing NADPH oxidase dual oxidase 2 (DUOX2) which, when elevated, adversely affects survival from pancreatic ductal adenocarcinoma (PDAC). Because the cGAS-STING pathway is known to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37a11980f34b5d4752ab40266d9a41f7
https://doi.org/10.1101/2022.05.14.491678
https://doi.org/10.1101/2022.05.14.491678
Autor:
Yongzhong Wu, Mariam M. Konaté, Melinda Hollingshead, Baktiar Karim, Becky Diebold, Jiamo Lu, Smitha Antony, Jennifer L. Meitzler, Agnes Juhasz, Guojian Jiang, Iris Dahan, Krishnendu Roy, James H. Doroshow
Previously, we demonstrated that pro-inflammatory cytokines enhance dual oxidase 2 (DUOX2)-dependent production of reactive oxygen species by human pancreatic ductal carcinoma (PDAC) cells, and that DUOX2 expression is significantly increased in pati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc3c770f5621f8774991ca4e6177720b
https://doi.org/10.1101/2022.02.13.480277
https://doi.org/10.1101/2022.02.13.480277
Autor:
Iris Dahan, Guojian Jiang, Rodrigo F. Chuaqui, Yongzhong Wu, James H. Doroshow, Michael J. Difilippantonio, Jiamo Lu, Smitha Antony, Krishnendu Roy, Jennifer L. Meitzler, Han Liu, Mariam M. Konaté, Hala R. Makhlouf, Agnes Juhasz
Publikováno v:
The Journal of Immunology. 203:2532-2544
Dual oxidase 2 (DUOX2) generates H2O2 that plays a critical role in both host defense and chronic inflammation. Previously, we demonstrated that the proinflammatory mediators IFN-γ and LPS enhance expression of DUOX2 and its maturation factor DUOXA2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f97af94db5fcf49af3896d953fbd9fd2
https://doi.org/10.4049/jimmunol.1800469
https://doi.org/10.4049/jimmunol.1800469
Autor:
David J. Mallick, Yongzhong Wu, Mariam M. Konaté, Becky A. Diebold, Smitha Antony, Jennifer L. Meitzler, Guojian Jiang, Jiamo Lu, Krishnendu Roy, James H. Doroshow
Publikováno v:
Cancer Research. 82:1318-1318
Pancreatic inflammation contributes to increased risk of pancreatic adenocarcinoma (PDAC) development through the release of pro-inflammatory cytokines and generation of reactive oxygen species (ROS). Interleukin-1 (IL-1) is a major upstream pro-infl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a9f49f2124683ae1635474497afd2c3
https://doi.org/10.1158/1538-7445.am2022-1318
https://doi.org/10.1158/1538-7445.am2022-1318
Autor:
Mariam M. Konaté, Smitha Antony, Yongzhong Wu, Annamaria Rapisarda, Petreena Campbell, David J. Mallick, Krishnendu Roy, James H. Doroshow, Becky A. Diebold, Guojian Jiang, Jennifer L. Meitzler, Jiamo Lu, Agnes Juhasz
Publikováno v:
Cancer Research. 81:2915-2915
Inflammatory bowel diseases are states of long-term inflammation of the colon resulting from an interplay of environmental factors and dysregulated immune responses. As inflammatory exposure increases over the time frame of active disease, patients w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9724e960088be98db9ade1e24845db86
https://doi.org/10.1158/1538-7445.am2021-2915
https://doi.org/10.1158/1538-7445.am2021-2915
Autor:
Mallick David, Stephen L. Wang, Smitha Antony, Becky A. Diebold, Mariam M. Konaté, Jiamo Lu, Roy Krishnendu, James H. Doroshow, Jennifer L. Meitzler, Guojian Jiang, Yongzhong Wu
Publikováno v:
Cancer Research. 81:1755-1755
There is a growing appreciation that pancreatic cancers harbor higher numbers of bacteria & fungi compared to normal pancreatic tissue in both humans & mice. These microbes have been suggested to contribute to pancreatic carcinogenesis, & impact ther
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1c27dfb0a235ab41877274f146bc414
https://doi.org/10.1158/1538-7445.am2021-1755
https://doi.org/10.1158/1538-7445.am2021-1755
Autor:
Han Liu, Guojian Jiang, Yongzhong Wu, Jiuping Ji, James H. Doroshow, Yiping Zhang, Mariam M. Konaté, Smitha Antony, Iris Dahan, Agnes Juhasz, Hala R. Makhlouf, Donna Butcher, Diana C. Haines, Dave S.B. Hoon, Krishnendu Roy, Jiamo Lu, Jennifer L. Meitzler
Publikováno v:
Molecular Carcinogenesis
NADPH oxidase 5 (NOX5) generated reactive oxygen species (ROS) have been implicated in signaling cascades that regulate cancer cell proliferation. To evaluate and validate NOX5 expression in human tumors, we screened a broad range of tissue microarra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b89bbd5d7e9e695243aadcf460cf1dcf
http://europepmc.org/articles/PMC5675809
http://europepmc.org/articles/PMC5675809
Autor:
Jiamo Lu, Giovanni Melillo, Jennifer L. Meitzler, Donna Butcher, Han Liu, Shikha Gaur, Smitha Antony, Xiwei Wu, Yongzhong Wu, Agnes Juhasz, Diana C. Haines, Guojian Jiang, James H. Doroshow, Susan Markel, Krishnendu Roy
Publikováno v:
The Journal of Biological Chemistry
Reactive oxygen species (ROS) play a critical role in cell signaling and proliferation. NADPH oxidase 1 (NOX1), a membrane-bound flavin dehydrogenase that generates O2˙̄, is highly expressed in colon cancer. To investigate the role that NOX1 plays
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7227089373d48342c4cf117dcca63afb
https://doi.org/10.1074/jbc.m116.768283
https://doi.org/10.1074/jbc.m116.768283