Zobrazeno 1 - 9
of 9
pro vyhledávání: '"L. Marco Hoesel"'
Autor:
Mary-Anne Purtill, Mary-Margaret Brandt, Aken Desai, Lora Z. Silverman, Patricia J. Posa, L. Marco Hoesel
Publikováno v:
The American Journal of Surgery. 201:320-323
BACKGROUND: Our institution initiated the implementation of the Surviving Sepsis Campaign guidelines in 2006. We hypothesize that the addition of a surgical intensivist improved results more than the implementation of the guidelines alone. METHODS: W
Autor:
Rachel P. List, Hongwei Gao, Nico van Rooijen, Daniel Rittirsch, L. Marco Hoesel, Richard R. Neubig, J. Vidya Sarma, Firas S. Zetoune, Stephanie R. McGuire, Brian A. Nadeau, Markus Huber-Lang, Peter A. Ward, A. Chen, Michael A. Flierl, Danielle E. Day
Publikováno v:
Nature. 449:721-725
The discovery that phagocytic blood cells (macrophages and neutrophils) are a significant source of catecholamines (noradrenaline and adrenaline), and can cause reinforcement of the acute inflammatory response, comes as a surprise. The body's inflamm
Autor:
J. Vidya Sarma, Peter A. Ward, Hongwei Gao, L. Marco Hoesel, Ren Feng Guo, Nicholas J. Rancilio
Publikováno v:
The Journal of Immunology. 177:612-620
The lung inflammatory response caused by intratracheal deposition of IgG immune complexes (IC) includes the production of IL-6, which signals through activation of STAT transcription factors. Recently, suppressor of cytokine signaling 3 (SOCS3) has b
Autor:
L. Marco Hoesel, Basel M. Touban, Kyros Ipaktchi, Wade R. Smith, Markus Huber-Lang, Andreas D. Niederbichler, Philip F. Stahel, Michael A. Flierl, Steven J. Morgan, Peter A. Ward, Daniel Rittirsch
Publikováno v:
Critical Care
Introduction Septic encephalopathy secondary to a breakdown of the blood-brain barrier (BBB) is a known complication of sepsis. However, its pathophysiology remains unclear. The present study investigated the effect of complement C5a blockade in prev
Publikováno v:
Journal of leukocyte biology. 81(1)
Frequently used experimental models of sepsis include cecal ligation and puncture, ascending colon stent peritonitis, and the i.p. or i.v. injection of bacteria or bacterial products (such as LPS). Many of these models mimic the pathophysiology of hu
Autor:
Thomas A. Neff, Hongwei Gao, Niels C. Riedemann, J. Vidya Sarma, Peter A. Ward, Firas S. Zetoune, Scott A. Tomlins, L. Marco Hoesel, Ren Feng Guo, Cecilia L. Speyer, Ellen M. Younkin, Yunfang Man
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 19(8)
During experimental sepsis in rodents after cecal ligation and puncture (CLP), excessive C5a is generated, leading to interactions with C5aR, loss of innate immune functions of neutrophils, and lethality. In the current study, we have analyzed the ex
Autor:
J. Vidya Sarma, Thomas A. Neff, Markus Huber-Lang, Firas S. Zetoune, Simona B Neff, Peter A. Ward, Cecilia L. Speyer, Hongwei Gao, Kurt D. Bernacki, Niels C. Riedemann, Stephanie R. McGuire, Ren Feng Guo, L. Marco Hoesel, Beatrice Beck-Schimmer
Publikováno v:
The American journal of pathology. 166(3)
There is mounting evidence that apoptosis plays a significant role in tissue damage during acute lung injury. To evaluate the role of the apoptosis mediators Fas and FasL in acute lung injury, Fas (lpr)- or FasL (gld)-deficient and wild-type mice wer
Autor:
Shannon D. McClintock, Nico van Rooijen, Firas S. Zetoune, Hongwei Gao, Renfeng Guo, Cecilia L. Speyer, Niels C. Riedemann, Thomas A. Neff, L. Marco Hoesel, Jayne S. Reuben, J. Vidya Sarma, Peter A. Ward
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 172(12)
Stat3 plays diverse roles in biological processes including cell proliferation, survival, apoptosis, and inflammation. Very little is known regarding its activation and function in the lung during acute inflammation. We now show that Stat3 activation
Autor:
J. Vidya Sarma, L. Marco Hoesel, Lei Sun, Firas S. Zetoune, Renfeng Guo, Hongwei Gao, Peter A. Ward, Michael A. Flierl, Thomas A. Neff
Publikováno v:
Molecular Immunology. 44:175