5-ALA induced PpIX fluorescence guided surgery: a clinical study of spectral complexity in healthy tissues and margin boundaries in high and low grade gliomas

Autor: David Rousseau, Pascal Kantapareddy, Laure Alston, J Guyotat, L. Mahieu-Williame, David Meyronet, Mathieu Hébert, B. Montcel

Publikováno v: Clinical and Preclinical Optical Diagnostics II.

Gliomas are diffuse brain tumors still hardly curable due to the difficulties to identify their margins. 5-ALA induced PpIX fluorescence measurements have enabled to gain in sensitivity for discriminating margin from healthy tissue but they remain li

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9b78d3319f542c23f710dcee02b43ccc
https://doi.org/10.1117/12.2526950

Spectral complexity of 5-ALA induced PpIX fluorescence in guided surgery: a clinical study towards the discrimination of healthy tissue and margin boundaries in high and low grade gliomas

Autor: Mathieu Hébert, B. Montcel, David Meyronet, L. M. Alston, David Rousseau, L. Mahieu-Williame, P. Kantapareddy, Jacques Guyotat

Publikováno v: Biomedical optics express
Biomedical optics express, Optical Society of America-OSA Publishing, 2019, 10 (5), pp.2478. ⟨10.1364/BOE.10.002478⟩

Gliomas are diffuse and hard to cure brain tumors. A major reason for their aggressive behavior is their property to infiltrate the brain. The gross appearance of the infiltrative component is comparable to normal brain, constituting an obstacle to e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6097ac366e430171882e52431ac7a197
https://hal.archives-ouvertes.fr/hal-02109250/document

Interventional fluorescence spectroscopy: preliminary results to detect tumor margins during glioma resection with two fluorescence spectra of PpIX

Autor: D. Meyronet, L. Mahieu-Williame, P. Kantapareddy, B. Montcel, David Rousseau, Jacques Guyotat, Mathieu Hébert, L. M. Alston

Publikováno v: Clinical and Preclinical Optical Diagnostics.

We show the feasibility of using an intraoperative spectroscopic device to identify tumors margins during glioma resection. The collected fluorescence spectra is fitted with two reference spectra of PpIX and the contribution of each spectrum enables

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::db3f4bd3cde2863d496ac711efce11bf
https://doi.org/10.1117/12.2286110

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