Zobrazeno 1 - 10
of 181
pro vyhledávání: '"L. MacIsaac"'
Publikováno v:
BMC Palliative Care, Vol 18, Iss 1, Pp 1-9 (2019)
Abstract Background Compassion has been identified as important for therapeutic relationships in clinical medicine however there have been few empirical studies looking at how compassion is expressed different contexts. The purpose of this study was
Externí odkaz:
https://doaj.org/article/166fc745e2be4523a48b738931a9a10e
Autor:
Ola E. Salama, Nikho Hizon, Melissa Del Vecchio, Kurt Kolsun, Mario A. Fonseca, David T. S. Lin, Oscar Urtatiz, Julia L. MacIsaac, Michael S. Kobor, Elizabeth A. C. Sellers, Vernon W. Dolinsky, Allison B. Dart, Meaghan J. Jones, Brandy A. Wicklow
Publikováno v:
Clinical Epigenetics, Vol 16, Iss 1, Pp 1-12 (2024)
Abstract Objective Youth-onset type 2 diabetes (T2D) is physiologically distinct from adult-onset, but it is not clear how the two diseases differ at a molecular level. In utero exposure to maternal type 2 diabetes (T2D) is known to be a specific ris
Externí odkaz:
https://doaj.org/article/7bffa8c1e7684ef8bb5927a17a02682a
Autor:
Mark A. Burton, Emma S. Garratt, Matthew O. Hewitt, Hanan Y. Sharkh, Elie Antoun, Leo D. Westbury, Elaine M. Dennison, Nicholas C. Harvey, Cyrus Cooper, Julia L. MacIsaac, Michael S. Kobor, Harnish P. Patel, Keith M. Godfrey, Karen A. Lillycrop
Publikováno v:
Skeletal Muscle, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract Background While ageing is associated with increased insulin resistance (IR), the molecular mechanisms underlying increased IR in the muscle, the primary organ for glucose clearance, have yet to be elucidated in older individuals. As epigene
Externí odkaz:
https://doaj.org/article/19ba354ebb6d410cb6decf8eb0a5ba68
Autor:
Ana I. Hernandez Cordero, Xuan Li, Julia Yang, Chen Xi Yang, Tawimas Shaipanich, Julie L. MacIsaac, Kristy Dever, Michael S. Kobor, Julio Montaner, Marianne Harris, Silvia Guillemi, Shu Fan Paul Man, Don D. Sin, Janice M. Leung
Publikováno v:
Biomedicines, Vol 12, Iss 6, p 1261 (2024)
Background: DNA methylation may be a link between HIV, aging, and the increased risk of lung comorbidities. We investigated whether bronchoalveolar lavage (BAL) cells of people living with HIV (PLWH) demonstrate epigenetic disruptions and advanced ep
Externí odkaz:
https://doaj.org/article/f701d3d267eb4a0f96bcf938a909d574
Autor:
Kurt P. Kolsun, BSc, Samantha Lee, MSc, Julia L. MacIsaac, PhD, Padmaja Subbarao, MD, MSc, Theo J. Moraes, MD, PhD, Piushkumar J. Mandhane, MD, PhD, Stuart E. Turvey, MBBS, DPhil, Michael S. Kobor, PhD, Meaghan J. Jones, PhD, Elinor Simons, MD, PhD
Publikováno v:
Journal of Allergy and Clinical Immunology: Global, Vol 2, Iss 4, Pp 100130- (2023)
Background: In the first year of life, DNA methylation (DNAm) patterns are established and are particularly susceptible to exposure-induced changes. Some of these changes may leave lasting effects by persistently altering gene expression or cell type
Externí odkaz:
https://doaj.org/article/81f55578c405431387e605d6ca784ed9
Autor:
Christopher W. Kuzawa, Calen P. Ryan, Linda S. Adair, Nanette R. Lee, Delia B. Carba, Julia L. MacIsaac, Kristy Dever, Parmida Atashzay, Michael S. Kobor, Thomas W. McDade
Publikováno v:
Epigenetics, Vol 17, Iss 11, Pp 1535-1545 (2022)
Epigenetic clocks quantify regular changes in DNA methylation that occur with age, or in relation to biomarkers of ageing, and are strong predictors of morbidity and mortality. Here, we assess whether measures of fetal nutrition and growth that predi
Externí odkaz:
https://doaj.org/article/e496b37a6a674f3aaede8da3bf3c2488
Autor:
Jacob Bergstedt, Sadoune Ait Kaci Azzou, Kristin Tsuo, Anthony Jaquaniello, Alejandra Urrutia, Maxime Rotival, David T. S. Lin, Julia L. MacIsaac, Michael S. Kobor, Matthew L. Albert, Darragh Duffy, Etienne Patin, Lluís Quintana-Murci, Milieu Intérieur Consortium
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
Many studies assess epigenetic marks in white blood cells, but it is unclear how much immune factors affect the epigenome. Here, the authors show that fine-scale blood cell composition and cytomegalovirus infection affect the DNA methylome of adults.
Externí odkaz:
https://doaj.org/article/d485673d79fb4ce58ac6fd1885bfaa9c
Autor:
Clarus Leung, Min Hyung Ryu, Anette Kocbach Bølling, Danay Maestre-Batlle, Christopher F. Rider, Anke Hüls, Oscar Urtatiz, Julie L. MacIsaac, Kevin Soon-Keen Lau, David Tse Shen Lin, Michael S. Kobor, Chris Carlsten
Publikováno v:
Respiratory Research, Vol 23, Iss 1, Pp 1-10 (2022)
Abstract Background Single nucleotide polymorphisms (SNPs) of peroxisome proliferator-activated receptor gamma (PPAR-γ; gene: PPARG) and oxidative stress genes are associated with asthma risk. However, whether such variants modulate responses to dib
Externí odkaz:
https://doaj.org/article/b68df42a54c3478aac04f4e497660015
Autor:
Sarah M. Merrill, Nicole Letourneau, Gerald F. Giesbrecht, Karlie Edwards, Julia L. MacIsaac, Jonathan W. Martin, Amy M. MacDonald, David W. Kinniburgh, Michael S. Kobor, Deborah Dewey, Gillian England-Mason, The APrON Study Team
Publikováno v:
Epigenomes, Vol 8, Iss 1, p 3 (2024)
Di(2-ethylhexyl) phthalate (DEHP) is a common plasticizer that can affect immune system development and susceptibility to infection. Aging processes (measured as epigenetic age acceleration (EAA)) may mediate the immune-related effects of prenatal ex
Externí odkaz:
https://doaj.org/article/7fbe9dcdc50c4de3ac2ac879cca11e96
Autor:
Chaini Konwar, Rebecca Asiimwe, Amy M. Inkster, Sarah M. Merrill, Gian L. Negri, Maria J. Aristizabal, Christopher F. Rider, Julie L. MacIsaac, Christopher Carlsten, Michael S. Kobor
Publikováno v:
Epigenetics & Chromatin, Vol 14, Iss 1, Pp 1-18 (2021)
Abstract Background Understanding the molecular basis of susceptibility factors to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is a global health imperative. It is well-established that males are more likely to acquire
Externí odkaz:
https://doaj.org/article/eb8dddcdb6ed41d08f9b4f0c914873af