Zobrazeno 1 - 10
of 52
pro vyhledávání: '"L. M. Viranga Tillekeratne"'
Autor:
Daniyah A. Almarghalani, Ghaith A. Bahader, Mohammad Ali, L. M. Viranga Tillekeratne, Zahoor A. Shah
Publikováno v:
Pharmaceuticals, Vol 17, Iss 1, p 114 (2024)
Neuroinflammation after intracerebral hemorrhage (ICH) is a crucial factor that determines the extent of the injury. Cofilin is a cytoskeleton-associated protein that drives neuroinflammation and microglia activation. A novel cofilin inhibitor (CI) s
Externí odkaz:
https://doaj.org/article/c666ceb9c7b34d37870f239f0fc9cd09
Autor:
L. M. Viranga Tillekeratne, Ayad Ayad Al-Hamashi, Samkeliso Dlamini, William Taylor, Radhika Koranne, Mary Kay Pflum, Ahmed T. Negmeldin, Joseph Knoff
Publikováno v:
Proceedings, Vol 22, Iss 1, p 63 (2019)
Epigenetic regulation of gene expression without changing DNA sequences is a promising strategy in developing therapeutic agents for human diseases, especially cancer. [...]
Externí odkaz:
https://doaj.org/article/9185cc5d77694202988cc68711419b19
Autor:
Riddhidev, Banerjee, Endri, Karaj, Sabitri, Lamichhane, Kotsull, Lauren, N., Nishanth, Kuganesan, Dragan, Isailovic, Mary Kay H, Pflum, James, Slama, William, Taylor, L. M. Viranga, Tillekeratne
Publikováno v:
In European Journal of Medicinal Chemistry 15 December 2022 244
Autor:
Endri Karaj, Shaimaa H. Sindi, Nishanth Kuganesan, Radhika A. Koranne, Joseph R. Knoff, Antonisamy William James, Yu Fu, Lauren N. Kotsull, Mary Kay Pflum, Zahoor Shah, William R. Taylor, L. M. Viranga Tillekeratne
Publikováno v:
Journal of Medicinal Chemistry. 65:14764-14791
HDAC inhibitors are an attractive class of cytotoxic agents for the design of hybrid molecules. Several HDAC hybrids have emerged over the years, but none combines HDAC inhibition with ferroptosis, a combination which is being extensively studied bec
Autor:
Endri Karaj, Shaimaa H. Sindi, Nishanth Kuganesan, Lalith Perera, William Taylor, L. M. Viranga Tillekeratne
Publikováno v:
Journal of Medicinal Chemistry. 65:11788-11817
Once considered potential liabilities, the modern era witnesses a renaissance of interest in covalent inhibitors in drug discovery. The available toolbox of electrophilic warheads is limited by constraints on tuning reactivity and selectivity. Follow
Publikováno v:
Drug Discovery Today
Graphical abstract
Highlights • The SARS-CoV-2 main protease is a prime drug target. • Coronavirus main proteases share a structurally conserved substrate-binding region. • The structure and sequence similarity of SARS-CoV-2 to SARS-CoV re
Highlights • The SARS-CoV-2 main protease is a prime drug target. • Coronavirus main proteases share a structurally conserved substrate-binding region. • The structure and sequence similarity of SARS-CoV-2 to SARS-CoV re
Autor:
Endri Karaj, Shaimaa H. Sindi, Nishanth Kuganesan, Lalith Perera, William Taylor, L. M. Viranga Tillekeratne
Covalent inhibitors have historically been considered potential liabilities in medicinal chemistry. The modern era witnesses a renaissance of interest in irreversible binders. The available toolbox of electrophilic warheads is limited with constraint
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::119551cc470b4369e3445611d1ac4f33
https://doi.org/10.26434/chemrxiv-2022-h9t07
https://doi.org/10.26434/chemrxiv-2022-h9t07
Autor:
Saleh I. Alaqel, Samkeliso Dlamini, Daniyah A. Almarghalani, Arjun Shettigar, Qasim Alhadidi, Sinali H. Kodithuwakku, Creed Stary, L. M. Viranga Tillekeratne, Zahoor A. Shah
Publikováno v:
ACS Chem Neurosci
Intracerebral hemorrhage (ICH) is devastating among stroke types with high mortality. To date, not a single therapeutic intervention has been successful. Cofilin plays a critical role in inflammation and cell death. In the current study, we embarked
Autor:
Abdulateef Alqahtani, Ayad A. Al-Hamashi, Matthew Dunworth, Joseph R. Knoff, Robert A. Casero, Mary Kay H. Pflum, Lalith Perera, Endri Karaj, L. M. Viranga Tillekeratne, Radhika Koranne, Maisha S. Rashid, Samkeliso Dlamini, William R. Taylor
Publikováno v:
Bioorg Chem
Despite the advances in treatment strategies, cancer is still the second leading cause of death in the USA. A majority of the currently used cancer drugs have limitations in their clinical use due to poor selectivity, toxic side effects and multiple
Autor:
Endri, Karaj, Samkeliso, Dlamini, Radhika, Koranne, Shaimaa H, Sindi, Lalith, Perera, William R, Taylor, L M, Viranga Tillekeratne
Publikováno v:
Bioorganic Chemistry. 122:105700
We recently reported a new class of imidazole-based chalcones as potential antimitotic agents. In view of their promising cytotoxic activity, a comprehensive structure-activity relationship (SAR) of these compounds was undertaken focusing on four maj