Zobrazeno 1 - 10
of 34
pro vyhledávání: '"L. M. Krasnykh"'
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 4, Pp 55-62 (2024)
Relevance. Coenzyme Q10 is one of the main components that maintain the balance of the body's redox regulatory system. Although some studies have examined plasma concentrations of CoQ10 in various diseases, the distribution of ubiquinol and ubiquinon
Externí odkaz:
https://doaj.org/article/117a033a8fe64d439fac0ea5dc65f7a6
Autor:
G. F. Vasilenko, L. M. Krasnykh, M. V. Zhuravleva, A. B. Prokofiev, G. I. Gorodetskaya, V. V. Smirnov, N. D. Bunyatyan
Publikováno v:
Регуляторные исследования и экспертиза лекарственных средств, Vol 12, Iss 3, Pp 331-340 (2022)
The relationship between dissolution and bioavailability is an example of the interdependency between the quality of a medicinal product and its safety and efficacy. The uniqueness of thioctic acid is that it can exist in an oxidised and a reduced fo
Externí odkaz:
https://doaj.org/article/7607f125c1184eeb86aeddd7dcd3b6ea
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 2, Pp 11-18 (2022)
Relevance of the study: The quantification of endogenous substances is an important task in experimental and clinical pharmacology. In the case of working with endogenous compounds, certain difficulties arise. The main one is the impossibility of obt
Externí odkaz:
https://doaj.org/article/995995fac907410ba96ec6c2f673fce5
Autor:
L. M. Krasnykh, O. A. Goroshko, G. F. Vasilenko, G. I. Gorodetskaya, V. V. Smirnov, T. A. Rodina
Publikováno v:
Безопасность и риск фармакотерапии, Vol 9, Iss 4, Pp 209-215 (2021)
Nonsteroidal anti-inflammatory drugs, including acetylsalicylic acid, can have a dose-dependent nephrotoxic effect. The study of the pharmacokinetics of acetylsalicylic acid products will contribute to timely detection and correction of side effects
Externí odkaz:
https://doaj.org/article/04ff71dfc9f64d4881746f18b981fe20
Publikováno v:
Регуляторные исследования и экспертиза лекарственных средств, Vol 9, Iss 3, Pp 146-152 (2019)
The article examines the role of ubiquinone as a redox molecule whose functions consist in electron transport in the mitochondrial respiratory chain and regeneration of endogenous antioxidants. Changes in electron redox pathways cause uncontrolled re
Externí odkaz:
https://doaj.org/article/f89fa6c155174aeaa7b594cfb3428247
Publikováno v:
Сеченовский вестник, Vol 10, Iss 1, Pp 16-21 (2019)
Introduction. Coenzyme Q10 plays an important role in the human body. Its main function is not only the transfer of electrons in the mitochondrial respiratory chain for the ATP synthesis, but it is also one of the most powerful antioxidants in the bo
Externí odkaz:
https://doaj.org/article/eb37b875b5954c5bb24f293486fa98e1
THE MODERN METHODS OF ANALYSIS OF OXIDIZED AND REDUCED FORMS OF COENZYME Q₁₀ IN BIOMATERIAL (REVIEW)
Publikováno v:
Разработка и регистрация лекарственных средств, Vol 0, Iss 1, Pp 84-88 (2019)
In the human body, coenzyme Q10 is in the oxidized and reduced forms and can be found in every organ. The review describes modern HPLC methods of coenzyme Q10 analysis using electrochemical, spectrophotometric and mass spectrometric detectors. In the
Externí odkaz:
https://doaj.org/article/aabeadcb51b545108fd0e91deb3e7c98
Autor:
L. M. Krasnykh, V. V. Smirnov, G. V. Ramenskaya, G. F. Vasilenko, I. P. Shilovsky, M. R. Haitov
Publikováno v:
Биопрепараты: Профилактика, диагностика, лечение, Vol 18, Iss 3, Pp 184-190 (2018)
Methods used to control the quality of peptide products depend on the level of development of analytical and bioorganic chemistry, and the level of instrumentation. Peptide identification is a difficult task and largely depends on the complexity of i
Externí odkaz:
https://doaj.org/article/a7845fdda29d488a99131ce12be377e1
Autor:
L. M. Krasnykh, V. V. Smirnov, E. A. Egorenkov, G. F. Vasilenko, S. P. Dementyev, G. V. Ramenskaya
Publikováno v:
Регуляторные исследования и экспертиза лекарственных средств, Vol 0, Iss 1, Pp 21-25 (2018)
Perindopril is a prodrug which is converted to an active metabolite perindoprilat in the human organism. The present study led to the development of a fast and easily reproducible procedure for simultaneous detection of perinoprilat and its metabolit
Externí odkaz:
https://doaj.org/article/3beaa5ec758e4ff6b43667f8379df6f5
Publikováno v:
Регуляторные исследования и экспертиза лекарственных средств, Vol 0, Iss 4, Pp 53-57 (2018)
The article discusses therapeutic drug monitoring (TDM) data for clozapine obtained in patients with various forms of schizophrenia undergoing treatment in hospital. Clozapine and its metabolite norclozapine concentrations and their response to the a
Externí odkaz:
https://doaj.org/article/7d82c416bb8341c99a8c46f8ee64dd1a