Zobrazeno 1 - 10 of 68 pro vyhledávání: '"L. M. Appelman"'
1
Acute, Subacute, and Subchronic Inhalation Toxicity Studies of Respirable Polymeric Methylene Diphenyl Diisocyanate (Polymeric MDI) Aerosol in Rats
Autor: L. M. Appelman, E. Löser, Victor J. Feron, C.F. Kuper, P.G.J. Reuzel
Publikováno v: Fundamental and Applied Toxicology. 22:186-194
Acute, Subacute, and Subchronic Inhalation Toxicity Studies of Respirable Polymeric Methylene Diphenyl Diisocyanate (Polymeric MDI) Aerosol in Rats. Reuzel, P. G. J., Kuper, C. F., Feron, V. J., Appelman, L. M., and Loser, E. (1994). Fundam. Appl. To
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c22bf3203e7f3e497f4d2966a65e15f1
https://doi.org/10.1006/faat.1994.1023
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3
Co-amoxiclav in recurrent acute otitis media: placebo controlled study
Autor: F. W. M. M. Touw-Otten, R A de Melker, Gerrit Jan Hordijk, C. L. M. Appelman, J. Q. P. J. Claessen
Publikováno v: BMJ. 303:1450-1452
OBJECTIVE--To determine the efficacy of coamoxiclav in children aged 6 months to 12 years with recurrent acute otitis media. DESIGN--A randomised double blind placebo controlled clinical trial. SETTING--General practice in the Netherlands. PATIENTS--
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6949b4c8a26185b02ff0d85ce834d5e9
https://doi.org/10.1136/bmj.303.6815.1450
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4
A review of clinical trials regarding treatment of acute otitis media
Autor: C. L. M. Appelman, F. W. M. M. Touw-Otten, Gerrit Jan Hordijk, R A de Melker, J. Q. P. J. Claessen
Publikováno v: Clinical otolaryngology and allied sciences. 17(3)
A survey was made of the English language literature on clinical trials of therapy in acute otitis media. The articles were analysed systematically for 24 parameters related to study design. We retrieved 50 studies published between 1965 and 1989. Su
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05bbe4e381603ea0ce88b74d6f3c9119
https://pubmed.ncbi.nlm.nih.gov/1505094
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6
Effect of variable versus fixed exposure levels on the toxicity of acetaldehyde in rats
Autor: W. R. F. Notten, Victor J. Feron, R. A. Woutersen, L. M. Appelman, R.N. Hooftman
Publikováno v: Journal of Applied Toxicology, 5, 6, 331-336
The effects of exposure pattern on the toxicity of acetaldehyde vapour were investigated in 4-week inhalation studies. Male rats were exposed to 500 or 150 and 110 ppm for 6 h per day/5 days per week. One group of animals was exposed without interrup
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fd27237b9631b3610d8f159831c797c
https://doi.org/10.1002/jat.2550060506
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7
One-year inhalation toxicity study of formaldehyde in male rats with a damaged or undamaged nasal mucosa
Autor: R. A. Woutersen, Victor J. Feron, L. M. Appelman, A. Zwart, H. E. Falke
Publikováno v: Journal of Applied Toxicology. 8:85-90
To study the effect of bilateral intranasal electrocoagulation damage on the susceptibility of rats to formaldehyde vapour, male Wistar rats with a damaged or undamaged nasal mucosa were exposed to atmospheres containing 0, 0.1, 1 or 10 ppm formaldeh
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce26e9943a10e2667e0b01db8bb71664
https://doi.org/10.1002/jat.2550080204
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8
Inhalation toxicity of acetaldehyde in rats. III. Carcinogenicity study☆
Autor: A. van Garderen-Hoetmer, Ruud Woutersen, L. M. Appelman, Victor J. Feron
Publikováno v: Toxicology. 41:213-231
Male and female Wistar rats were exposed to acetaldehyde vapour at nominal concentrations of 0, 750, 1500 or 3000/1000 ppm during 6 h/day, 5 days/week for up to 28 months. Major compound-related effects included increased mortality, growth retardatio
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::569052f5a528764648b535ed6e758c1b
https://doi.org/10.1016/0300-483x(86)90201-5
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9
Comparative sensitivity of histo-pathology and specific lung parameters in the detection of lung injury
Autor: R.N. Hooftman, L. M. Appelman, C. F. Kuper
Publikováno v: Scopus-Elsevier
Journal of Applied Toxicology, 1, 8, 59-65
The sensitivity of different parameters for the determination of lung injury caused by nitrogen dioxide (NO2) was investigated. Male rats were exposed to concentrations of 0, 4, 10 or 25 ppm NO2 for 6 h/day, for 7, 14 or 21 days. Histopathology of th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d77ae6b0661a195ef9b5e3de9832d309
https://pubmed.ncbi.nlm.nih.gov/2895784
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10
Subacute (4-week) inhalation toxicity study of formaldehyde in male rats: 8-hour intermittent versus 8-hour continuous exposures
Autor: Victor J. Feron, L. M. Appelman, W.R. Leeman, J. W. G. M. Wilmer, R. A. Woutersen
Publikováno v: Journal of applied toxicology : JAT. 7(1)
Male Wistar rats were exposed for 4 weeks, 5 days a week, to 0 (controls), 5 or 10 ppm formaldehyde continuously (8 hours a day), or to 10 or 20 ppm formaldehyde interruptedly (eight 30 min exposure periods separated by 30 min non-exposure periods).
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f51155d9f76a94f283634c1ae7df4e34
https://pubmed.ncbi.nlm.nih.gov/3611592
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