Zobrazeno 1 - 10
of 1 013
pro vyhledávání: '"L. Laslett"'
Autor:
Natasha Stevens, Chigozie Ezegbe, Valery Fuh-Ngwa, Kalina Makowiecki, Amin Zarghami, Phuong Tram Nguyen, Julie Sansom, Kate Smith, Laura L. Laslett, Meg Denham, Carlie L. Cullen, Michael H. Barnett, Mark R. Hinder, Monique Breslin, Kaylene M. Young, Bruce V. Taylor
Publikováno v:
Trials, Vol 25, Iss 1, Pp 1-22 (2024)
Abstract Background Multiple sclerosis (MS) is a chronic neurological condition and the leading cause of non-traumatic disability in young adults. MS pathogenesis leads to the death of oligodendrocytes, demyelination, and progressive central nervous
Externí odkaz:
https://doaj.org/article/f63bb6c9caf244c59917e3eca9caacc5
Autor:
Sarah Thomas, Bruce V Taylor, Laura L Laslett, Ingrid van der Mei, Cynthia Honan, Sue Shapland, Alisée Huglo
Publikováno v:
BMJ Open, Vol 14, Iss 5 (2024)
Introduction Multiple sclerosis (MS) causes a wide variety of symptoms. Loss of income due to sickness and early retirement comprise one-third of the total cost of MS in Australia. An intervention that maximises work productivity and keeps people wit
Externí odkaz:
https://doaj.org/article/24b5800a9705411ebcbad51931cd211b
Publikováno v:
npj Microgravity, Vol 8, Iss 1, Pp 1-15 (2022)
Abstract Humans are spending an increasing amount of time in space, where exposure to conditions of microgravity causes 1–2% bone loss per month in astronauts. Through data collected from astronauts, as well as animal and cellular experiments condu
Externí odkaz:
https://doaj.org/article/77fd07523cb9407e844bc7194a65b7f5
Autor:
L. L. Laslett, B. Antony, A. E. Wluka, C. Hill, L. March, H. I. Keen, P. Otahal, F. M. Cicuttini, G. Jones
Publikováno v:
Trials, Vol 21, Iss 1, Pp 1-14 (2020)
Abstract Background Knee osteoarthritis (OA) is a common and important cause of pain and disability, but interventions aimed at modifying structures visible on imaging have been disappointing. While OA affects the whole joint, synovitis and effusion
Externí odkaz:
https://doaj.org/article/9c81e7ae51094d53a4093697d3738bbb
Autor:
Maciej Daniszewski, Quan Nguyen, Hun S. Chy, Vikrant Singh, Duncan E. Crombie, Tejal Kulkarni, Helena H. Liang, Priyadharshini Sivakumaran, Grace E. Lidgerwood, Damián Hernández, Alison Conquest, Louise A. Rooney, Sophie Chevalier, Stacey B. Andersen, Anne Senabouth, James C. Vickers, David A. Mackey, Jamie E. Craig, Andrew L. Laslett, Alex W. Hewitt, Joseph E. Powell, Alice Pébay
Publikováno v:
iScience, Vol 7, Iss , Pp 30-39 (2018)
Summary: We assessed the pluripotency of human induced pluripotent stem cells (iPSCs) maintained on an automated platform using StemFlex and TeSR-E8 media. Analysis of transcriptome of single cells revealed similar expression of core pluripotency gen
Externí odkaz:
https://doaj.org/article/7a57b9886f4c465e9568b2e61af1aab8
Autor:
Dawn Aitken, Laura L. Laslett, Guoqi Cai, Catherine Hill, Lyn March, Anita E. Wluka, Yuanyuan Wang, Leigh Blizzard, Flavia Cicuttini, Graeme Jones
Publikováno v:
BMC Musculoskeletal Disorders, Vol 19, Iss 1, Pp 1-12 (2018)
Abstract Background Bisphosphonates are a class of drugs that slow bone loss and are a promising candidate to treat knee osteoarthritis (OA) patients. In a pilot study, we demonstrated that zoledronic acid reduced knee pain and size of subchondral bo
Externí odkaz:
https://doaj.org/article/8c3d9913a04846a288f079d4fe6a9eb7
Publikováno v:
Stem Cell Research, Vol 26, Iss , Pp 36-43 (2018)
Characterisation of mouse pluripotent stem cells has revealed two distinct pluripotent states, naive and primed, that maintain characteristics of the pre and post implanted epiblast respectively. Recent studies have developed several culture systems
Externí odkaz:
https://doaj.org/article/3ff45556e5314a69ab33c145f24c5f05
Autor:
Guoqi Cai, Laura L Laslett, Dawn Aitken, Flavia Cicuttini, Lyn March, Catherine Hill, Tania Winzenberg, Graeme Jones
Publikováno v:
Therapeutic Advances in Musculoskeletal Disease, Vol 11 (2019)
Background: The aim of this study was to compare the efficacy and safety of zoledronic acid (ZA) plus intravenous methylprednisolone (VOLT01) to ZA, and placebo for knee osteoarthritis. Methods: A single-center, double-blind, randomized controlled tr
Externí odkaz:
https://doaj.org/article/44623bebd018462e829b967fcfc17b03
Publikováno v:
Bioengineering, Vol 7, Iss 2, p 47 (2020)
A critical shortage of donor livers for treating end-stage liver failure signifies the urgent need for alternative treatment options. Hepatocyte-like cells (HLC) derived from various stem cells represent a promising cell source for hepatocyte transpl
Externí odkaz:
https://doaj.org/article/0c8868b093de47dcba62d12d886e6e84
Autor:
Alexandra J Harvey, Carmel O'Brien, Jack Lambshead, John R Sheedy, Joy Rathjen, Andrew L Laslett, David K Gardner
Publikováno v:
PLoS ONE, Vol 13, Iss 3, p e0193949 (2018)
Reprogramming somatic cells to a pluripotent cell state (induced Pluripotent Stem (iPS) cells) requires reprogramming of metabolism to support cell proliferation and pluripotency, most notably changes in carbohydrate turnover that reflect a shift fro
Externí odkaz:
https://doaj.org/article/72ebe40befa2460da0c6aef954027d1a