Výsledky vyhledávání

Akademický článek

Fibroblast Activation Protein (FAP)-Mediated Cleavage of Type III Collagen Reveals Serum Biomarker Potential in Non-Small Cell Lung Cancer and Spondyloarthritis

Autor: Rasmus S. Pedersen, Jeppe Thorlacius-Ussing, Maria G. Raimondo, Lasse L. Langholm, Georg Schett, Andreas Ramming, Morten Karsdal, Nicholas Willumsen

Publikováno v: Biomedicines, Vol 12, Iss 3, p 545 (2024)

Fibroblast activation protein (FAP) is a known promoter of tumor development and is associated with poor clinical outcome for various cancer types. Being specifically expressed in pathological conditions including multiple types of fibrosis and cance

Externí odkaz: https://doaj.org/article/7841d04d187d419a8e4496e730df5dba

Zobrazit plný text záznamu

Akademický článek

Endotrophin, an extracellular hormone, in combination with neoepitope markers of von Willebrand factor improves prediction of mortality in the ECLIPSE COPD cohort

Autor: Sarah R. Rønnow, Lasse L. Langholm, Morten A. Karsdal, Tina Manon-Jensen, Ruth Tal-Singer, Bruce E. Miller, Jørgen Vestbo, Diana J. Leeming, Jannie M. B. Sand

Publikováno v: Respiratory Research, Vol 21, Iss 1, Pp 1-6 (2020)

Abstract Background Lung epithelial damage, activation of the wound healing cascade, and remodeling of the extracellular matrix (ECM) play a major role in chronic obstructive pulmonary disease (COPD). The pro-peptide of type VI collagen has been iden

Externí odkaz: https://doaj.org/article/e432bd97f6824e32b4de4a568577bf44

Zobrazit plný text záznamu

Plný text ve formátu HTML

Akademický článek

Plasma Kallikrein-Activated TGF-β Is Prognostic for Poor Overall Survival in Patients with Pancreatic Ductal Adenocarcinoma and Associates with Increased Fibrogenesis

Autor: Rasmus S. Pedersen, Neel I. Nissen, Christina Jensen, Jeppe Thorlacius-Ussing, Tina Manon-Jensen, Majken L. Olesen, Lasse L. Langholm, Hadi M. H. Diab, Lars N. Jorgensen, Carsten P. Hansen, Inna M. Chen, Julia S. Johansen, Morten A. Karsdal, Nicholas Willumsen

Publikováno v: Biomolecules, Vol 12, Iss 9, p 1315 (2022)

Pancreatic ductal adenocarcinoma (PDAC) is a hard-to-treat cancer due to the collagen-rich (fibrotic) and immune-suppressed microenvironment. A major driver of this phenomenon is transforming growth factor beta (TGF-β). TGF-β is produced in an inac

Externí odkaz: https://doaj.org/article/090d7e20b41848078ab5b37623004dd1

Zobrazit plný text záznamu

Plný text ve formátu HTML

Akademický článek

Single site suppressors of a fission yeast temperature-sensitive mutant in cdc48 identified by whole genome sequencing.

Autor: Irina N Marinova, Jacob Engelbrecht, Adrian Ewald, Lasse L Langholm, Christian Holmberg, Birthe B Kragelund, Colin Gordon, Olaf Nielsen, Rasmus Hartmann-Petersen

Publikováno v: PLoS ONE, Vol 10, Iss 2, p e0117779 (2015)

The protein called p97 in mammals and Cdc48 in budding and fission yeast is a homo-hexameric, ring-shaped, ubiquitin-dependent ATPase complex involved in a range of cellular functions, including protein degradation, vesicle fusion, DNA repair, and ce

Externí odkaz: https://doaj.org/article/e1c3fa01655a45f6926fab2138ed01f3

Zobrazit plný text záznamu