Zobrazeno 1 - 10
of 1 736
pro vyhledávání: '"L. Lane"'
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-8 (2023)
Abstract Dopamine transmission has been implicated in motor and cognitive function. In Parkinson’s disease (PD), dopamine replacement using the precursor drug l-DOPA is the predominant treatment approach, but long-term exposure leads to the onset o
Externí odkaz:
https://doaj.org/article/cfff42f7ea5e4e1ab38d4f5ab4bbf112
Autor:
James Hennegan, Aled H. Bryant, Lauren Griffiths, Matthieu Trigano, Oliver J.M. Bartley, Joanna J. Bartlett, Carys Minahan, Willy Antoni Abreu de Oliveira, Eylan Yutuc, Sotirios Ntikas, Christos S. Bartsocas, Margarita Markouri, Eleni Antoniadou, Ioanna Laina, Owain W. Howell, Meng Li, Yuqin Wang, William J. Griffiths, Emma L. Lane, Mariah J. Lelos, Spyridon Theofilopoulos
Publikováno v:
iScience, Vol 27, Iss 1, Pp 108670- (2024)
Summary: Dysregulated cholesterol metabolism has been linked to neurodegeneration. We previously found that free, non-esterified, 7α,(25R)26-dihydroxycholesterol (7α,26-diHC), was significantly elevated in the cerebrospinal fluid of patients with P
Externí odkaz:
https://doaj.org/article/cc11eaec18cb42d988985f04f6f16725
Autor:
Garrett Deletti, Sajan D. Green, Caleb Weber, Kristen N. Patterson, Swapnil S. Joshi, Tushar M. Khopade, Mathew Coban, James Veek-Wilson, Thomas R. Caulfield, Rajesh Viswanathan, Amy L. Lane
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract The 2,5-diketopiperazines are a prominent class of bioactive molecules. The nocardioazines are actinomycete natural products that feature a pyrroloindoline diketopiperazine scaffold composed of two D-tryptophan residues functionalized by N-
Externí odkaz:
https://doaj.org/article/0e378fe5aa2f4a71a4bc4a9d3e10d906
Autor:
Bikash Panthi, Rania M. Mohamed, Beatriz E. Adrada, Medine Boge, Rosalind P. Candelaria, Huiqin Chen, Kelly K. Hunt, Lei Huo, Ken-Pin Hwang, Anil Korkut, Deanna L. Lane, Huong C. Le-Petross, Jessica W. T. Leung, Jennifer K. Litton, Sanaz Pashapoor, Frances Perez, Jong Bum Son, Jia Sun, Alastair Thompson, Debu Tripathy, Vicente Valero, Peng Wei, Jason White, Zhan Xu, Wei Yang, Zijian Zhou, Clinton Yam, Gaiane M. Rauch, Jingfei Ma
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Early prediction of neoadjuvant systemic therapy (NAST) response for triple-negative breast cancer (TNBC) patients could help oncologists select individualized treatment and avoid toxic effects associated with ineffective therapy in patients unlikely
Externí odkaz:
https://doaj.org/article/ce05b7a736b747c6b99c4058b0f5d015
Autor:
Gloria V. Echeverria, Shirong Cai, Yizheng Tu, Jiansu Shao, Emily Powell, Abena B. Redwood, Yan Jiang, Aaron McCoy, Amanda L. Rinkenbaugh, Rosanna Lau, Alexander J. Trevarton, Chunxiao Fu, Rebekah Gould, Elizabeth E. Ravenberg, Lei Huo, Rosalind Candelaria, Lumarie Santiago, Beatriz E. Adrada, Deanna L. Lane, Gaiane M. Rauch, Wei T. Yang, Jason B. White, Jeffrey T. Chang, Stacy L. Moulder, W. Fraser Symmans, Susan G. Hilsenbeck, Helen Piwnica-Worms
Publikováno v:
npj Breast Cancer, Vol 9, Iss 1, Pp 1-9 (2023)
Abstract Patient-derived xenograft (PDX) models of breast cancer are an effective discovery platform and tool for preclinical pharmacologic testing and biomarker identification. We established orthotopic PDX models of triple negative breast cancer (T
Externí odkaz:
https://doaj.org/article/1aeaec90b47b427c8b0d10b0dad9ddf6
Autor:
Emma L. Lane, Mariah J. Lelos
Publikováno v:
Disease Models & Mechanisms, Vol 15, Iss 10 (2022)
Externí odkaz:
https://doaj.org/article/ae04654ed41048849bff645e111829e8
Autor:
Stefanie L. Lane
Publikováno v:
Applications in Plant Sciences, Vol 10, Iss 4, Pp n/a-n/a (2022)
Abstract Premise Seed recruitment niches along estuarine elevation gradients are seldom experimentally field‐tested under tidal regimes of the Pacific Northwest of North America. Addressing this knowledge gap is important to better understand estua
Externí odkaz:
https://doaj.org/article/e6d233580dbd49f780117585c3206397
Publikováno v:
ACS Omega, Vol 6, Iss 16, Pp 10840-10858 (2021)
Externí odkaz:
https://doaj.org/article/017f7d5cd1c445d8930d912c99f7b3a8
Publikováno v:
Saudi Pharmaceutical Journal, Vol 29, Iss 2, Pp 206-212 (2021)
First line treatment for Parkinson’s disease (PD) is typically either L-dopa or a non-ergot dopamine agonist (DA). However, the options for the treatment of motor symptoms in PD patients have increased in the last thirty years, which have seen seve
Externí odkaz:
https://doaj.org/article/a12193d253044f69a87458d7213167cb
Autor:
Mary S. Guirguis, Beatriz Adrada, Miral Patel, Frances Perez, Rosalind Candelaria, Wei Yang, Jia Sun, Rania M. Mohamed, Medine Boge, H. T. Carisa Le-Petross, Jessica Leung, Gary J. Whitman, Deanna L. Lane, Marion E. Scoggins, Tanya Moseley, Benjamin Musall, Jason White, Sanaz Pashapoor, Peng Wei, Jong Bum Son, Ken-Pin Hwang, Bikash Panthi, Mark Pagel, Lei Huo, Kelly K. Hunt, Elizabeth Ravenberg, Alastair M. Thompson, Jennifer K. Litton, Vicente Valero, Debu Tripathy, Stacy Moulder, Clinton Yam, Jingfei Ma, Gaiane Rauch
Publikováno v:
Cancer Research. 83:P1-05
PURPOSE Triple-negative breast cancer (TNBC) is a heterogeneous disease with variable response to neoadjuvant therapy (NAT). Pathologic complete response (pCR) has become a prognostic marker for overall and disease-free survival. The aim of this stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::612132872b999f0360c0224ef6e43bda
https://doi.org/10.1158/1538-7445.sabcs22-p1-05-15
https://doi.org/10.1158/1538-7445.sabcs22-p1-05-15