Výsledky vyhledávání

Modulation of the Wnt pathway through inhibition of CLK2 and DYRK1A by lorecivivint as a novel, potentially disease-modifying approach for knee osteoarthritis treatment

Publikováno v: Osteoarthritis and Cartilage. 27:1347-1360

Summary Objectives Wnt pathway upregulation contributes to knee osteoarthritis (OA) through osteoblast differentiation, increased catabolic enzymes, and inflammation. The small-molecule Wnt pathway inhibitor, lorecivivint (SM04690), which previously

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::251737b2dfc868332d0b50bdf73625f9
https://doi.org/10.1016/j.joca.2019.05.006

Zobrazit plný text záznamu

THU0046 Small molecule inhibitor of the wnt pathway (SM04755) as a potential topical treatment for psoriasis

Autor: V. Deshmukh, L. Lamangan, Melinda Pedraza, Yusuf Yazici

Publikováno v: THURSDAY, 14 JUNE 2018.

Background Psoriasis (PSO) is an autoimmune disease, causing patches of thick, inflamed, scaly skin due to excessive proliferation of skin cells1. Wnt signalling plays an important role in PSO, regulating inflammation and keratinocyte proliferation.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::079aae79d2bac864a26b25830d406db7
https://doi.org/10.1136/annrheumdis-2018-eular.4752

Zobrazit plný text záznamu

SM04690, A potential disease-modifying treatment for knee osteoarthritis, functions through inhibition of CLK2 and DYRK1A, novel molecular regulators of Wnt signaling, chondrogenesis, and inflammation

Autor: M. Pedraza, C. Lai, Kevin Chiu, Yusuf Yazici, M. Ibanez, V. Deshmukh, A.L. O'Green, L. Lamangan, S. Cho, A. Ghias, T. Seo, L. Do, J. Cahiwat, C. Bossard

Publikováno v: Osteoarthritis and Cartilage. 27:S37

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9bbf6dc15318eea78d5fafa5a1685dcb
https://doi.org/10.1016/j.joca.2019.02.053

Zobrazit plný text záznamu

1097 Small molecule Wnt pathway inhibitor (SM0755) as a potential topical treatment for psoriasis

Autor: V. Deshmukh, L. Lamangan, M. Pedraza, Yusuf Yazici

Publikováno v: Journal of Investigative Dermatology. 138:S186

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f2b3cea0684e619ba942dc09f4563baa
https://doi.org/10.1016/j.jid.2018.03.1110

Zobrazit plný text záznamu

Akademický článek

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Vyhledávací nástroje:

Upřesnit hledání