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Akademický článek
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Akademický článek
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Autor:
Rebecca L. Lackman, Peter Cresswell
Publikováno v:
The Journal of Immunology. 177:4833-4840
IFN-γ-inducible lysosomal thiol reductase (GILT), which plays a role in MHC class II-restricted processing and presentation of Ags containing disulfide bonds, can be induced in various cell types by the cytokine IFN-γ. APCs, including circulating m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::894d6077ecd311f1debb4ba4436a291c
https://doi.org/10.4049/jimmunol.177.7.4833
https://doi.org/10.4049/jimmunol.177.7.4833
Publikováno v:
Traffic (Copenhagen, Denmark). 8(9)
Gamma interferon-induced lysosomal thiolreductase (GILT) is expressed constitutively in antigen-presenting cells, where it reduces disulfide bonds to facilitate antigen presentation. GILT is synthesized as an enzymatically active precursor protein an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70f9d5190aae10e583eb37010264ba6f
https://pubmed.ncbi.nlm.nih.gov/17555533
https://pubmed.ncbi.nlm.nih.gov/17555533
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 177(12)
Ag processing and presentation via MHC class II is essential for activation of CD4+ T lymphocytes. γ-IFN-inducible lysosomal thiol reductase (GILT) is present in the MHC class II loading compartment and has been shown to facilitate class II Ag proce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::169256dce1cf425b6b4bb179f9655c9a
https://pubmed.ncbi.nlm.nih.gov/17142755
https://pubmed.ncbi.nlm.nih.gov/17142755
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 99(19)
γ-Interferon-inducible lysosomal thiol reductase (GILT) is constitutively expressed in antigen-presenting cells. GILT facilitates unfolding of endocytosed antigens in MHC class II-containing compartments by enzymatically reducing disulfide bonds. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a26ab7c7e3dde29df87cd62498f2de10
https://pubmed.ncbi.nlm.nih.gov/12198183
https://pubmed.ncbi.nlm.nih.gov/12198183
Autor:
N, Chauret, B, Dobbs, R L, Lackman, K, Bateman, D A, Nicoll-Griffith, D M, Stresser, J M, Ackermann, S D, Turner, V P, Miller, C L, Crespi
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 29(9)
Recently, a novel nonfluorescent probe 3-[2-(N,N-diethyl-N-methylammonium)-ethyl]-7-methoxy-4-methylcoumarin (AMMC), which produces a fluorescent metabolite AMHC (3-[2-(N,N-diethyl-N-methylammonium)ethyl]-7-hydroxy-4-methylcoumarin) was used with mic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::774704df99b987261dcdbadd6bd67104
https://pubmed.ncbi.nlm.nih.gov/11502727
https://pubmed.ncbi.nlm.nih.gov/11502727
Autor:
F D, Armstrong, S R, Toledano, K, Miloslavich, L, Lackman-Zeman, J D, Levy, C L, Gay, W B, Schuman, P E, Fishkin
Publikováno v:
International journal of cancer. Supplement = Journal international du cancer. Supplement. 12
Because there were limited measures available to assess health-related quality of life (HRQL) in children with chronic illnesses, this study was initiated to develop an empirically derived questionnaire for use in evaluating HRQL issues in children t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f0edcf64648d1a67c7005f628b5e9422
https://pubmed.ncbi.nlm.nih.gov/10679865
https://pubmed.ncbi.nlm.nih.gov/10679865
Autor:
Nathalie Chauret, James A. Yergey, Deborah A. Nicoll-Griffith, Jacques-Yves Gauthier, Rebecca L. Lackman, Nathalie Tremblay, Jean Marois, José M. Silva
Publikováno v:
Analytical biochemistry. 276(2)
The standard method to evaluate CYP3A inhibition is to study the conversion of the specific CYP3A probe testosterone to its 6 beta-hydroxy metabolite in human liver microsomes, in the absence and presence of potential inhibitors. Quantification of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::150ad603728f268c7a1c8587d7aa477c
https://pubmed.ncbi.nlm.nih.gov/10603245
https://pubmed.ncbi.nlm.nih.gov/10603245
Publikováno v:
Annals of plastic surgery. 40(4)
High-grade sarcomas have a high rate of local recurrence as well as distant metastases. This has led to the development of intra-arterial chemotherapy (IAC) as part of a multimodal approach to control local disease and/or reduce the extent of surgica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::539e36ce66c657b790b3b25aa9d0d857
https://pubmed.ncbi.nlm.nih.gov/9555993
https://pubmed.ncbi.nlm.nih.gov/9555993