Zobrazeno 1 - 10
of 28
pro vyhledávání: '"L. L. Key"'
Publikováno v:
Calcified Tissue International. 63:346-350
Osteoclasts use a variety of chemical agents to degrade bone. One important component of this process is the generation of superoxide. It has been reported that nicotinamide adenine dinucleotide phosphate (NADPH) oxidase is the enzyme responsible for
Abstracts from the symposium on recent advances in Paget’s disease of bone and related bone diseases
Autor:
Allan Lipton, Allen M. Spiegel, M. Heffernan, Michael P. Whyte, J. L. Doppman, Stanley Wallach, Ethel S. Siris, P. J. Meunier, Toshiyuki Yoneda, Henry G. Bone, Roy D. Altman, S. Martinez, R. Knight, R. Theriault, Samuel A. Wells, J. J. Eckardt, J. Seaman, Melvin M. Grumbach, E. J. A. Gerritsen, Will G. Ryan, C. C. Chen, Gordon B. Cutler, D. Reitsma, G. N. Hortobagyi, William L. Ries, L. L. Key, Felix A. Conte, Orlo H. Clark, Penelope Feuillan, Janet Jones, G. A. W. Gooding, F. S. Kaplan, Michael R. McClung, Frederick R. Singer, H. Watts, Selna L. Kaplan, Francis H. Glorieux, P. Z. Wirganowicz, D. Sudhaker Rao, Pierre D. Delmas, Roland Chapurlat, J. P. Bilezikian
Publikováno v:
Calcified Tissue International. 59:219-227
Publikováno v:
Biochemical Journal. 269:459-464
An osteoblast-like human osteosarcoma cell line (U2-OS) has been shown to possess a vitamin K-dependent carboxylation system which is similar to the system in human HepG2 cells and in liver and lung from the rat. In an ‘in vitro’ system prepared
Publikováno v:
Radiology. 174:681-685
The size and shape of pituitary glands in 169 children, adolescents, and young adults were analyzed with T1-weighted sagittal magnetic resonance (MR) images. In patients younger than 12 years old, no pituitary gland was found to be more than 6 mm in
Publikováno v:
Molecular and cellular biochemistry. 199(1-2)
Severe, malignant osteopetrosis is a disease characterized by osteoclasts that fail to resorb bone. Serious defects in the ability of white blood cells to eradicate infectious agents confound the clinical course. Defective superoxide generation by ne
Publikováno v:
The Journal of urology. 157(5)
We determined the incidence of defects in 3 enzymes, namely 3beta-hydroxysteroid dehydrogenase, 17alpha-hydroxylase and 17,20-lyase, on the testosterone biosynthetic pathway in boys with hypospadias.We evaluated 30 boys with a 46,XY karyotype, fully
Publikováno v:
Current therapy in endocrinology and metabolism. 6
Publikováno v:
American journal of hematology. 53(3)
A 16-month-old boy, diagnosed at age 3 months with osteopetrosis, was treated since age 6 months with rhIFN-gamma in combination with rhM-CSF. The child developed acute respiratory distress within 1 hr of a paternal platelet transfusion. Both the chi
Publikováno v:
Experimental hematology. 23(2)
The macrophage colony-stimulating factor (M-CSF) gene expression in osteopetrotic mice (op/op) is defective due to a point-mutation in the M-CSF gene [1]. However, almost all osteopetrotic patients have been shown to have a normal or elevated circula
Publikováno v:
Clinical orthopaedics and related research. (294)
Medical treatments of osteopetrosis have attempted to improve hematologic function, reduce the osteosclerotic condition, and/or improve immune function. Prednisone therapy has improved hematologic function in some patients, but has not resulted in a