Výsledky vyhledávání - "L. L. Froelich"

Inhibition of ex vivo neutrophil activation by oral LY293111, a novel leukotriene B4 receptor antagonist

Autor: B. J. Cerimele, R. A. Lucas, S. M. Spaethe, P. Marder, L. L. Froelich, B. H. Petersen, T. Tanner

Publikováno v: British Journal of Clinical Pharmacology. 42:457-464

1. The effects of orally administered LY293111 on ex vivo neutrophil Mac-1 upregulation were determined in a total of 24 healthy male subjects within three study periods. 2. In the first period, eight volunteers received 60 mg LY293111 or placebo thr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61e7ba999b7b587a30b822dec3337332
https://doi.org/10.1046/j.1365-2125.1996.43210.x

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Benzophenone dicarboxylic acid antagonists of leukotriene B4. 2. Structure-activity relationships of the lipophilic side chain

Autor: L L Froelich, D M Gapinski, B E Mallett, William T. Jackson

Publikováno v: Journal of Medicinal Chemistry. 33:2807-2813

A series of lipophilic benzophenone dicarboxylic acid derivatives were found to inhibit the binding of the potent chemotaxin leukotriene B4 (LTB4) to its receptor on intact human neutrophils. Activity at the LTB4 receptor was determined by using a [3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e289e6ecd468b0aaed745becf5588265
https://doi.org/10.1021/jm00172a020

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Benzophenone dicarboxylic acid antagonists of leukotriene B4. 1. Structure-activity relationships of the benzophenone nucleus

Autor: D M Gapinski, B E Mallett, L L Froelich, William T. Jackson

Publikováno v: Journal of Medicinal Chemistry. 33:2798-2807

A series of lipophilic benzophenone dicarboxylic acid derivatives was prepared which inhibited the binding of the potent chemotaxin leukotriene B4 to its receptor(s) on intact human neutrophils. With a radioligand-binding assay as a measure of recept

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54b8010e74298d44e41d402317ab43b5
https://doi.org/10.1021/jm00172a019

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Pharmacologic actions of the second-generation leukotriene B4 receptor antagonist LY293111: in vitro studies

Autor: W T, Jackson, L L, Froelich, R J, Boyd, J P, Schrementi, D L, Saussy, R M, Schultz, J S, Sawyer, M J, Sofia, D K, Herron, T, Goodson, D W, Snyder, P A, Pechous, S M, Spaethe, C R, Roman, J H, Fleisch

Publikováno v: The Journal of pharmacology and experimental therapeutics. 288(1)

The in vitro actions were investigated of LY293111, a potent and selective leukotriene B4 (LTB4) receptor antagonist, on human neutrophils, human blood fractions, guinea pig lung membranes, and guinea pig parenchymal and tracheal strips. The IC50 for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::996b6f278ef8a0043be276e322cdd84a
https://pubmed.ncbi.nlm.nih.gov/9862783

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The discovery of LY293111, a novel, potent and orally active leukotriene B4 receptor antagonist of the biphenylphenol class

Autor: M J, Sofia, P, Floreancig, N, Bach, S R, Baker, K, Nelson, J S, Sawyer, R, Baldwin, S L, Cockerham, J H, Fleisch, L L, Froelich, W T, Jackson, P, Marder, C R, Roman, D L, Saussy, S A, Silbaugh, S M, Spaethe, P W, Stengel

Publikováno v: Advances in experimental medicine and biology.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::54fe637429ecdefdf648b1dcf9b4cec6
https://pubmed.ncbi.nlm.nih.gov/9547580

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Specific inhibition of leukotriene B4-induced neutrophil activation by LY223982

Autor: W T, Jackson, R J, Boyd, L L, Froelich, B E, Mallett, D M, Gapinski

Publikováno v: The Journal of pharmacology and experimental therapeutics. 263(3)

LY223982, (E)-5-(3-carboxybenzoyl)-2-((6-(4-methoxyphenyl)-5- hexenyl)oxy)benzenepropanoic acid, is a newly discovered potent inhibitor of specific binding of leukotriene B4 (LTB4) to its receptor on human neutrophils. This study demonstrated that th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b3d2682789ca37d778dd5fc25c2a4ad0
https://pubmed.ncbi.nlm.nih.gov/1335049

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Binding of a novel radioiodinated thromboxane A2/prostaglandin H2 antagonist to guinea pig lung membranes

Autor: D L, Saussy, P D, Clark, D L, Gunn, D E, Mais, L L, Froelich

Publikováno v: Eicosanoids. 5(1)

The utilization of a novel radioiodinated TXA2/PGH2 receptor antagonist, ISAP (7-[(1R,2S,3S,5R)-6,6-dimethyl-3(4- iodobenzenesulfonylamino)-bicyclo[3.1.1]-hept-2-yl]-5(Z)-heptenoic acid) to characterize TXA2/PGH2 receptors from guinea pig lung parenc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ba40966dede4990b481ccf278ebc05fd
https://pubmed.ncbi.nlm.nih.gov/1419073

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Characterization of the spatial arrangement of the two acid-binding sites on the human neutrophil LTB4 receptor

Autor: M O, Chaney, L L, Froelich, D M, Gapinski, B E, Mallett, W T, Jackson

Publikováno v: Receptor. 2(3)

A series of lipophilic benzophenone dicarboxylic acids have been shown to be inhibitors of the binding of LTB4 to its receptors on intact human neutrophils (Gapinski et al. (1990). Structure-activity relationships indicated that maximum activity was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a04a1ff1655fcc323ab2889a80eacd8d
https://pubmed.ncbi.nlm.nih.gov/1335328

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Akademický článek

Harmonized diagnostic criteria for Alzheimer's disease: recommendations.

Autor: Morris JC; Department of Neurology, Washington University, St. Louis, MO, USA., Blennow K, Froelich L, Nordberg A, Soininen H, Waldemar G, Wahlund LO, Dubois B

Publikováno v: Journal of internal medicine [J Intern Med] 2014 Mar; Vol. 275 (3), pp. 204-13.

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