Výsledky vyhledávání - "L. L. Brunilina"

Regiospecific S-aminoalkylation of 5-substituted 6-hydroxy-2-thiouracil derivatives in the synthesis of structural analogs of isothiobarbamine

Autor: P. P. Deshevov, V. V. Chapurkin, Ivan A. Novakov, M. B. Nawrozkij, O. V. Vostrikova, B. D. Korenkov, D. S. Sheikin, L. L. Brunilina, I. A. Kirillov

Publikováno v: Russian Chemical Bulletin. 70:943-948

Regiospecific S-monoaminoalkylation of 5-substituted derivatives of 6-hydroxy-2-thiouracil with free N,N-dialkyl-N-(2-chloroethyl)amines in anhydrous PriOH was described for the first time. In compliance with the rules and regulations of green chemis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e0f2e0c0b8bca3cdfb8f112c3f1765f5
https://doi.org/10.1007/s11172-021-3171-x

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Dexoxadrol and its bioisosteres: structure, synthesis, and pharmacological activity

Autor: A. S. Mkrtchyan, Konstantin V. Balakin, D. S. Sheikin, L. L. Brunilina, Ivan A. Novakov, M. B. Navrotskii

Publikováno v: Russian Chemical Bulletin. 69:1625-1671

The review addresses the complete anthology of the development and evolution of dexoxadrol derivatives comprising a class of highly efficient NMDA receptor antagonists. Main approaches to the synthesis of dexoxadrol and enantiomeric 1-(2-piperidyl)et

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::49d00dc08f4108ed4515f759b9fcbc1e
https://doi.org/10.1007/s11172-020-2946-9

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Synthesis and structure-activity relationships of the novel isothiobarbamine analogues with lowered basicity

Autor: L. L. Brunilina, V. V. Chapurkin, Evsey A. Ruchko, Dmitry S. Sheikin, Dominique Schols, Y. P. Kuznetsov, I. A. Novakov, M. B. Nawrozkij

Publikováno v: AIP Conference Proceedings.

Synthesis of the novel Isothiobarbamine analogues with lowered basicity has been prepared. The peculiarities of their synthesis and preliminary data on their biological activity are presented.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3525f32b22ee9567f6113e93580b6b7b
https://doi.org/10.1063/5.0018050

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Aminolysis of 6-[1-(2,6-difluorophenyl)cyclopropyl]-5-methyl-2-(nitroamino)pyrimidin-4(3H)-one

Autor: L. L. Brunilina, E. A. Ruchko, A. A. Vernigora, Vadim V. Kachala, Ivan A. Novakov, D. S. Sheikin, I. A. Kirillov, A. S. Yablokov, A. S. Mkrtchyan, M. B. Navrotskii

Publikováno v: Russian Journal of Organic Chemistry. 53:1844-1850

The aminolysis of 6-[1-(2,6-difluorophenyl)cyclopropyl]-5-methyl-2-(nitroamino)pyrimidin-4(3H)-one with various amines in butan-1-ol and under solvent-free conditions is successful when the amino group in the reagent is sterically unshielded and the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::798cc86f191f0139086518b9227bb69d
https://doi.org/10.1134/s1070428017120107

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Bis(4-nitrophenyl)phosphorylazide as a reagent for direct azidation of polyfunctional derivatives of pyrimidin-4(3Н)-one

Autor: Ivan A. Novakov, Boris S. Orlinson, A. S. Yablokov, L. L. Brunilina, M. B. Navrotskii, A. S. Babushkin, M. D. Robinovich

Publikováno v: Russian Journal of General Chemistry. 87:219-223

The application of bis-(4-nitrophenyl)phosphorylazide–1,8-diazabicyclo[5.4.0]undec-7-ene system for direct transformation of polyfunctional derivatives of pyrimidin-4(3H)-one in the corresponding 4-azidopyrimidines has been suggested for the first

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2e77f1492b9327e68ea6a4e088a2b0a9
https://doi.org/10.1134/s1070363217020116

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C(2)-Functionalization of pyrimidin-4(3H)-one derivatives in the synthesis of its biologically active derivatives

Autor: L. L. Brunilina, M. B. Navrotskii, E. K. Zakharova, Ivan A. Novakov

Publikováno v: Russian Chemical Bulletin. 64:2545-2561

Different approaches to the formation of biologically active isocytosine, uracil, and 2-thiouracil derivatives based on the C(2)-regioselective functionalization of pyrimidin-4(3H)one framework were considered.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::32bd4c65dc683653ac410dfbbe3f87ce
https://doi.org/10.1007/s11172-015-1190-1

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Experimental and quantum chemical study of the reactions of 2-methyloxirane with 5-alkyl-6-(2,6-dihalobenzyl)-2-thioxo1,2-dihydropyrimidine-4(3H)-one derivatives

Autor: D. V. Steglenko, V. I. Minkin, Ivan A. Novakov, E. A. Ruchko, M. B. Nawrozkij, A. S. Yablokov, L. L. Brunilina

Publikováno v: Russian Chemical Bulletin. 64:525-533

The reactions of 5-alkyl-6-(2,6-dihalobenzyl)-2-thioxo-1,2-dihydropyrimidin-4(3H)-one with 2-methyloxirane in an alkaline medium afforded uracil and 2-[(2-hydroxyprop-1yl)sulfanyl]pyrimidin-4(3H)-one derivatives. The mechanism proposed for these tran

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f6971dc485f1dc03719388c0df588637
https://doi.org/10.1007/s11172-015-0896-4

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