Zobrazeno 1 - 10
of 57
pro vyhledávání: '"L. Koymans"'
Publikováno v:
SAR and QSAR in Environmental Research. 12:359-366
This paper describes a specialized database dedicated exclusively to the cytochrome P450 superfamily. The system provides the impression of superfamily's nomenclature and describes structure and function of different P450 enzymes. Information on P450
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7e76ebd0d8cef9f712d44788e2f477d
https://doi.org/10.1080/10629360108033244
https://doi.org/10.1080/10629360108033244
Publikováno v:
Chemical Research in Toxicology, 9, 1092-1102. American Chemical Society
Commandeur, J N M, King, L J, Koymans, L & Vermeulen, N P E 1996, ' Bioactivation of S-(2,2-dihalo-1,1-difluoroethyl)-L-cysteines and S-(trihalovinyl)-L-cysteines by cysteine S-conjugate beta-lyase: Indications for formation of both thionoacylating species and thiiranes as reactive intermediates. ', Chemical Research in Toxicology, vol. 9, pp. 1092-1102 . https://doi.org/10.1021/tx960049b
Commandeur, J N M, King, L J, Koymans, L & Vermeulen, N P E 1996, ' Bioactivation of S-(2,2-dihalo-1,1-difluoroethyl)-L-cysteines and S-(trihalovinyl)-L-cysteines by cysteine S-conjugate beta-lyase: Indications for formation of both thionoacylating species and thiiranes as reactive intermediates. ', Chemical Research in Toxicology, vol. 9, pp. 1092-1102 . https://doi.org/10.1021/tx960049b
The covalent binding of reactive intermediates, formed by beta-elimination of cysteine S-conjugates of halogenated alkenes, to nucleophiles was studied using 19F-NMR and GC-MS analysis. beta-Elimination reactions were performed using rat renal cytoso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff76309aa432d5315c4a33d42424010d
https://hdl.handle.net/1871/25277
https://hdl.handle.net/1871/25277
Publikováno v:
Koymans, L, Donné-op den Kelder, G M, te Koppele, J M & Vermeulen, N P 1993, ' Cytochromes P450 : their active-site structure and mechanism of oxidation ', Drug Metabolism Reviews, vol. 25, no. 3, pp. 325-87 . https://doi.org/10.3109/03602539308993979
(1993). Cytochromes P450: Their Active-Site Structure and Mechanism of Oxidation. Drug Metabolism Reviews: Vol. 25, No. 3, pp. 325-387.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::578b7dc9098003ef121767cb04910e8b
https://hdl.handle.net/1871.1/ebbe2307-cc33-4da0-a84e-86a02bb17361
https://hdl.handle.net/1871.1/ebbe2307-cc33-4da0-a84e-86a02bb17361
Autor:
H, Vanden Bossche, L, Koymans
Publikováno v:
Mycoses. 41
The article gives an overview on the history of the discovery of P450 cytochromes and on their occurrence in nature, especially on their interactions with metabolic pathways in fungi. The significance of the P450 cytochromes in the ergosterol synthes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::31d04a13dd5a29d16fb4c10116ff4ab5
https://pubmed.ncbi.nlm.nih.gov/9717384
https://pubmed.ncbi.nlm.nih.gov/9717384
Autor:
L. Koymans
Publikováno v:
Pharmacy worldscience : PWS. 15(2)
In conclusion, our studies have shown that computational chemistry techniques are very useful to elucidate mechanisms for the oxidation of substrates by cytochromes P-450 and to gain insight into the active site structures of these enzymes. In a simi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4617965d382b772464b0cdae9e369b0
https://pubmed.ncbi.nlm.nih.gov/8490590
https://pubmed.ncbi.nlm.nih.gov/8490590
Autor:
Nico P. E. Vermeulen, J. M. Te Koppele, G. M. Donne-Op Den Kelder, J. J. P. Heykants, S.A.B.E. van Acker, L. Koymans, K. Lavrijsen, W. Meuldermans
Publikováno v:
Koymans, L, Vermeulen, N P E, van Acker, S A B E, te Koppele, J M, Heykants, J J P, Lavrijsen, K, Meuldermans, W & Donné-Op den Kelder, G M 1992, ' A predictive model for substrates of cytochrome P450-debrisoquine (2D6) ', Chemical Research in Toxicology, vol. 5, no. 2, pp. 211-219 . https://doi.org/10.1021/tx00026a010
Chemical Research in Toxicology, 5(2), 211-219. American Chemical Society
Chemical Research in Toxicology, 5(2), 211-219. American Chemical Society
Molecular modeling techniques were used to derive a predictive model for substrates of cytochrome P450 2D6, an isozyme known to metabolize only compounds with one or more basic nitrogen atoms. Sixteen substrates, accounting for 23 metabolic reactions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6b3efb75d4658b6a8408121aa2750c0
https://hdl.handle.net/1871.1/9bf11a9b-b863-414f-8e06-6e82d101e45b
https://hdl.handle.net/1871.1/9bf11a9b-b863-414f-8e06-6e82d101e45b
Publikováno v:
Journal of Basic and Clinical Physiology and Pharmacology. 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa389b41cd399fdd57289300b2d51f6b
https://doi.org/10.1515/jbcpp.1992.3.s1.100
https://doi.org/10.1515/jbcpp.1992.3.s1.100
Publikováno v:
Molecular pharmacology. 37(3)
The cytochrome P-450-mediated activation of phenacetin (PHEN) to reactive intermediates by two hypothetical mechanisms has been studied by use of SV 6-31G ab initio energy and spin distribution calculations. In our calculations, the cytochrome P-450
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::12e8867f0bc4f429154eeef6dad0026f
https://pubmed.ncbi.nlm.nih.gov/2314392
https://pubmed.ncbi.nlm.nih.gov/2314392
Autor:
M. G. Darlison, A. N. Bateson, R. J. Harvey, W. Wisden, E. A. Barnard, H. Loosfelt, M. Atger, A. Gulochon-Mantel, M. Misrahi, M. Perrot-Applanat, M. T. Vu Hai, F. Lorenzo, E. Milgrom, Chris J. van Koppen, Neil M. Nathanson, J. D. Naber, J. J. S. van Rensen, A. Baarslag, L. Koymans, G. M. Donné -Op den Keider, N. P. E. Vermeiden, P. P. Kelder, N. J. de Mol, L. A. 't Han, L. H. M. Janssen, S. P. van Helden, H. W. Hilbers, M. J. van Prooge, A. C. A. Jansen, L. H. M. Jansen, Anja Garritsen, Ad P. Jzerman, Margot W. Beukers, Willem Soudijn, LAGM vd Brock, Z. Zylicz, H. Hofs, D. J. Th. Wagener, J. P. G. Ballesta, P. Lelieveld, HCJ Ottenheijm, I. den Daas, P. G. Tepper, D. I. Mastebroek-Helder, A. S. Horn, W. Timmerman, B. G. J. Bohus, Durk Dijkstra, Swier Copinga, Jan B. de Vries, Sjaak den Daas, Alan S. Horn, P. N. Span, B. G. Quik, K. J. H. van Buuren, D. M. J. Veenstra, S. C. M. Levering, B. Rademaker, C. G. Huisman, M. de Boer, E. E. Moret, J. J. M. Holthuis, R. J. Driebergen, P. N. Reinhoudt, W. Verboom, A. A. van Til, F. B. van Duijneveldt, W. Vleeming, A. Stam, E. P. Bleuel, H. H. van Roolj, J. Wemer, A. J. Porsius, J. Riezebos, D. J. de Wildt, W. Vieeming, H. H. van Rooij, J. de Jong, P. R. Schopfs, R. C. A. Onderwater, H. M. Pinedo, W. J. F. van der Vijgh, A. Bast, J. F. de Vlieger, C. I. A. Doelman, M. M. Brozius, R. Leurs, H. Timmerman, M. J. Smit, A. van der Vliet, Marcel A. H. de Zwart, Henricus M. M. Bastianns, Deborah Brouwer, Henk van der Goot, Hendrik Timmerman, S. Ciere, G. R. M. M. Haenen, J. Ch. Eriks, S. A. van Acker, L. Kovmans, G. M. Donné -Op den Kelder, N. P. E. Vermeulcn, A. R. Goeptar, J. M. te Koppele, N. P. E. Vermeulen, E. P. A. Neve, G. J. Stijnties, J. M. te Koppete, N. P. F. Vermeulen, I. M. Pirovano, A. P. Ijzerman, A. M. van Rhee, W. Soudijn, C. J. Witmans, C. J. Grol, W. G. J. HoL, C. Verlinde, F. R. Opperdoes
Publikováno v:
Pharmaceutisch Weekblad. 11:M1-M12
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16df7f21aeb41e194ae5570dc933463c
https://doi.org/10.1007/bf02196049
https://doi.org/10.1007/bf02196049
Autor:
Gabriëlle M. Donné-Op den Kelder, Nico P. E. Vermeulen, L. Koymans, Joop H. van Lenthe, Ronald Van de Straat
Publikováno v:
Koymans, L, Lenthe, J H, Van de Straat, R, Donné-Op den Kelder, G M & Vermeulen, N P 1989, ' A theoretical study on the metabolic activation of paracetamol by cytochrome P-450 : indications for a uniform oxidation mechanism ', Chemical Research in Toxicology, vol. 2, no. 1, pp. 60-6 . https://doi.org/10.1021/tx00007a011
Chemical Research in Toxicology, 2(1), 60-6. American Chemical Society
Chemical Research in Toxicology, 2(1), 60-6. American Chemical Society
The cytochrome P-450 mediated activation of paracetamol (PAR) to the reactive electrophilic intermediate N-acetyl-p-benzoquinone imine (NAPQI) has been studied by use of SV 6-31G ab initio energy calculations and spin distributions. A simplified mode
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7185078fb8fc0afad227f1f17d8a8839
https://pubmed.ncbi.nlm.nih.gov/2519233
https://pubmed.ncbi.nlm.nih.gov/2519233