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pro vyhledávání: '"L. Koeb"'
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Autor:
Martina Schaublin-Loidl, K. Powell, L. Koeb, Chin B. Eap, Max Stabl, Pierre Baumann, Theo W. Guentert
Publikováno v:
Clinical Pharmacology & Therapeutics. 59:322-331
Concentrations of total (R) + (S) and of the enantiomers (R) and (S) of thioridazine and metabolites were measured in 21 patients who were receiving 100 mg thioridazine for 14 days and who were comedicated with moclobemide (450 mg/day). Two patients
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f01818f20324300ccfe2eddc6739d5f7
https://doi.org/10.1016/s0009-9236(96)80010-5
https://doi.org/10.1016/s0009-9236(96)80010-5
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 669:271-279
Thioridazine is a commonly prescribed phenothiazine drug administered as a racemate and it is believed that its antipsychotic effect is mainly associated with (R)-thioridazine. A method based on high-performance liquid chromatography has been develop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a409eeede96a4c86c255e3fa43afb87
https://doi.org/10.1016/0378-4347(95)00096-2
https://doi.org/10.1016/0378-4347(95)00096-2
Publikováno v:
Scopus-Elsevier
A two-step high-performance liquid chromatography method is described, using a CN column and an alpha 1-acid glycoprotein column, which allows the measurement of the enantiomers of the hydroxy metabolites of trimipramine in plasma of trimipramine-tre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::406b2f470bb0daedc78786c4ab78387e
https://doi.org/10.1097/00007691-199210000-00007
https://doi.org/10.1097/00007691-199210000-00007
Autor:
Michèle Jonzier-Perey, Johann W. Meyer, M. Amey, Dominique Baettig, Christian Bryois, Pierre Baumann, L. Koeb, Christian Monney, Brigitte Woggon
Publikováno v:
Therapeutic Drug Monitoring. 14:1-8
The metabolism of most tricyclic antidepressants and some phenothiazine neuroleptics is under the genetic control of hepatic cytochrome P-450IID6, which also regulates the metabolism of dextromethorphan. This study investigated the effect of treatmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ead15d1ad14a1eed19fc8806c5c8a2b
https://doi.org/10.1097/00007691-199202000-00001
https://doi.org/10.1097/00007691-199202000-00001
Publikováno v:
Neuropsychobiology. 25:214-220
The pharmacokinetics and pharmacodynamics (waking EEG) of 75 mg trimipramine taken orally were determined in two healthy volunteers on two separate occasions, once without and once after comedication with 2 × 50 mg quinidine. Quinidine, a potent cyt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4432d584358734d5a46672d52c20b2ea
https://doi.org/10.1159/000118840
https://doi.org/10.1159/000118840
Autor:
J.B. Cohn, C.S. Wilcox, W.T. Smiths, Luigi Gigli, J.C. Stringfellow, B. Bonin, P. Reymond, Josep Maria Arqué, Chin B. Eap, L. Koeb, P. Bizouard, A. Souche, Gilles Bertschy, R. Ancill, Nariyoshi Yamaguchi, A. Garibaldi, Fabrizio Stefanini, B. Vandel, A. Cataldi, J.C. Pecknold, R.E. Gammans, Ermanno Rolandi, Kenzo Kurokawa, Pierre Baumann, Hiroshi Matsuda, Daniel Sechter, K. Rickels, R. Franceschini, Tommaso Barreca, L.F. Fabre, C. Gandolfo, Thierry Buclin, Ferran Balada, Rafael Torrubia, Nives Stefani, Maurizio Sabbadini, S. Nezelof, B. MacNeill, S. Laurian, R.J. Seidehamel, Kinichi Hisada, Giorgio Bernardi, S. Vandel, Grazia Marciani, A.J. Hvizdos, M. Gaetz, T. Francois, Maria Kusalic, Itsuki Jibiki
Publikováno v:
Neuropsychobiology. 25:I-IV
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::79f05d6779daed178ad06e24b82eb649
https://doi.org/10.1159/000118832
https://doi.org/10.1159/000118832
Publikováno v:
Journal of chromatography. 652(1)
A gas chromatographic—mass spectrometric (GC—MS) method has been developed, for the determination of trimipramine (TRI), desmethyltrimipramine (DTRI), didesmethyltrimipramine (DDTRI), 2-hydroxytrimipramine (2-OH-TRI) and 2-hydroxydesmethyltrimipr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cfa738880b915d455e51a53e938e374
https://pubmed.ncbi.nlm.nih.gov/8014234
https://pubmed.ncbi.nlm.nih.gov/8014234
Publikováno v:
Neuropsychobiology. 25(4)
The pharmacokinetics and pharmacodynamics (waking EEG) of 75 mg trimipramine taken orally were determined in two healthy volunteers on two separate occasions, once without and once after comedication with 2 x 50 mg quinidine. Quinidine, a potent cyto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c95ca62b0f55478bd07fb54cad340768
https://pubmed.ncbi.nlm.nih.gov/1454163
https://pubmed.ncbi.nlm.nih.gov/1454163
Publikováno v:
Therapeutic drug monitoring. 13(4)
The ring sulfoxidation of thioridazine (THD), a widely used neuroleptic agent, yields two diastereoisomeric pairs, fast- and slow-eluting (FE and SE) thioridazine 5-sulfoxide (THD 5-SO). Until now, studies in which concentrations of these metabolites
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3bfae8df2ae5943dab8cde5dc6fe3b44
https://pubmed.ncbi.nlm.nih.gov/1780970
https://pubmed.ncbi.nlm.nih.gov/1780970