Zobrazeno 1 - 10
of 136
pro vyhledávání: '"L. Keys"'
Autor:
S. Anslan, M. Azizi Rad, J. Buckel, P. Echeverria Galindo, J. Kai, W. Kang, L. Keys, P. Maurischat, F. Nieberding, E. Reinosch, H. Tang, T. V. Tran, Y. Wang, A. Schwalb
Publikováno v:
Biogeosciences, Vol 17, Pp 1261-1279 (2020)
The Tibetan Plateau (TP) is the largest alpine plateau on Earth and plays an important role in global climate dynamics. On the TP, climate change is happening particularly fast, with an increase in air temperature twice the global average. The partic
Externí odkaz:
https://doaj.org/article/6b862e43fc7b418e8c0fb511be23c0c3
Autor:
Yale Jiang, Erick Forno, Yueh-Ying Han, Zhongli Xu, Donglei Hu, Nadia Boutaoui, Celeste Eng, Edna Acosta-Pérez, Scott Huntsman, Angel Colón-Semidey, Kevin L. Keys, José R. Rodríguez-Santana, María Alvarez, Maria Pino-Yanes, Glorisa Canino, Wei Chen, Esteban G. Burchard, Juan C. Celedón
Publikováno v:
Epigenetics, Vol 16, Iss 5, Pp 577-585 (2021)
Latinos are heavily affected with childhood asthma. Little is known about epigenetic mechanisms of asthma in Latino youth. We conducted a meta-analysis of two epigenome-wide association studies (EWAS) of asthma, using DNA from white blood cells (WBCs
Externí odkaz:
https://doaj.org/article/cf590e9b7397474d90b1a02e04c96e6c
Autor:
Kevin L Keys, Angel C Y Mak, Marquitta J White, Walter L Eckalbar, Andrew W Dahl, Joel Mefford, Anna V Mikhaylova, María G Contreras, Jennifer R Elhawary, Celeste Eng, Donglei Hu, Scott Huntsman, Sam S Oh, Sandra Salazar, Michael A Lenoir, Jimmie C Ye, Timothy A Thornton, Noah Zaitlen, Esteban G Burchard, Christopher R Gignoux
Publikováno v:
PLoS Genetics, Vol 16, Iss 8, p e1008927 (2020)
The genetic control of gene expression is a core component of human physiology. For the past several years, transcriptome-wide association studies have leveraged large datasets of linked genotype and RNA sequencing information to create a powerful ge
Externí odkaz:
https://doaj.org/article/22c150d8426343a09ce557fa67ba7215
Autor:
Linda Kachuri, Angel C. Y. Mak, Donglei Hu, Celeste Eng, Scott Huntsman, Jennifer R. Elhawary, Namrata Gupta, Stacey Gabriel, Shujie Xiao, Kevin L. Keys, Akinyemi Oni-Orisan, José R. Rodríguez-Santana, Michael A. LeNoir, Luisa N. Borrell, Noah A. Zaitlen, L. Keoki Williams, Christopher R. Gignoux, Esteban González Burchard, Elad Ziv
Publikováno v:
Nature Genetics.
We explored the role of genetic ancestry in shaping the genetic architecture of whole blood gene expression using whole genome and RNA sequencing data from 2,733 African American and Hispanic/Latino children. We find that heritability of gene express
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6d75481c7484dabb2022d2c9eef8a4c
https://doi.org/10.1038/s41588-023-01377-z
https://doi.org/10.1038/s41588-023-01377-z
Autor:
Ludovica Montanucci, Hafid Laayouni, Begoña Dobon, Kevin L Keys, Jaume Bertranpetit, Juli Peretó
Publikováno v:
PLoS ONE, Vol 13, Iss 12, p e0208782 (2018)
Metabolic networks comprise thousands of enzymatic reactions functioning in a controlled manner and have been shaped by natural selection. Thanks to the genome data, the footprints of adaptive (positive) selection are detectable, and the strength of
Externí odkaz:
https://doaj.org/article/72aa11f27ee54eff9723eee8fcdb0337
Autor:
David J. Erle, Walter L. Eckalbar, Max A. Seibold, Celeste Eng, Jose R. Rodriguez-Santana, Scott Huntsman, Esteban G. Burchard, Marquitta J. White, Cydney Urbanek, Luke R. Bonser, Kevin L. Keys, Eunice Y. Lee, Donglei Hu, Satria Sajuthi, Angel C.Y. Mak, Hyun Min Kang, Gonçalo R. Abecasis, Michael C. Zody, Deborah A. Nickerson, Soren Germer, Deepti Jain, Elad Ziv
Publikováno v:
American journal of respiratory and critical care medicine, vol 202, iss 7
Rationale: Puerto Ricans have the highest childhood asthma prevalence in the United States (23.6%); however, the etiology is uncertain.Objectives: In this study, we sought to uncover the genetic architecture of lung function in Puerto Rican youth wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea46e1965153868a8d21ba8685217ffb
https://doi.org/10.1164/rccm.202002-0351oc
https://doi.org/10.1164/rccm.202002-0351oc
Autor:
Esteban G. Burchard, Yueh-Ying Han, Donglei Hu, Erick Forno, Scott Huntsman, Celeste Eng, Maria Pino-Yanes, Glorisa Canino, Yale Jiang, Nadia Boutaoui, Kevin L. Keys, Jose R. Rodriguez-Santana, Edna Acosta-Pérez, María Alvarez, Angel Colón-Semidey, Wei Chen, Zhongli Xu, Juan C. Celedón
Publikováno v:
Epigenetics
Latinos are heavily affected with childhood asthma. Little is known about epigenetic mechanisms of asthma in Latino youth. We conducted a meta-analysis of two epigenome-wide association studies (EWAS) of asthma, using DNA from white blood cells (WBCs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad456264a0abf9992a6f6a18b4e39aa9
https://doi.org/10.1080/15592294.2020.1809872
https://doi.org/10.1080/15592294.2020.1809872
Autor:
Max A. Seibold, Sandra Salazar, Zhanghua Chen, Soren Germer, Satria Sajuthi, Deepti Jain, Frank D. Gilliland, B. Saef, Jaehyun Joo, Esteban G. Burchard, Lara Heermans Winterkorn, Hakon Hakonarson, Marquitta J. White, Gonçalo R. Abecasis, Catherine Reeves, Ann Chen Wu, Shujie Xiao, Deborah A. Nickerson, Fred Lurmann, Scott Huntsman, Michael C. Zody, Patrick M. A. Sleiman, Celeste Eng, L. Keoki Williams, Kevin L. Keys, Eunice Y. Lee, Sam S. Oh, Hongsheng Gui, Angel C.Y. Mak, Donglei Hu, Hyun Min Kang, Rajesh Kumar, Elad Ziv, Blanca E. Himes, Fernando D. Martinez
Publikováno v:
Genetics
Genetics, vol 215, iss 3
Genetics, vol 215, iss 3
Baseline lung function is a standard diagnostic criterion used by clinicians to detect lung diseases. It is a complex trait significantly influenced by both genetics and environmental factors...
Baseline lung function, quantified as forced expir
Baseline lung function, quantified as forced expir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe4b53b7984fef51fb940e7c0e381714
http://europepmc.org/articles/PMC7337089
http://europepmc.org/articles/PMC7337089
Autor:
Esther Herrera-Luis, Annie Li, Angel C. Y. Mak, Javier Perez-Garcia, Jennifer R. Elhawary, Sam S. Oh, Donglei Hu, Celeste Eng, Kevin L. Keys, Scott Huntsman, Kenneth B. Beckman, Luisa N. Borrell, Jose Rodriguez-Santana, Esteban G. Burchard, Maria Pino-Yanes
Publikováno v:
Clinical Epigenetics
Clinical epigenetics, vol 14, iss 1
Clinical epigenetics, vol 14, iss 1
Introduction DNA methylation studies have associated methylation levels at different CpG sites or genomic regions with lung function. Moreover, genetic ancestry has been associated with lung function in Latinos. However, no epigenome-wide association
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::657eee0bdf8a2b232ed9ffc7cbf33d2c
https://doi.org/10.1186/s13148-022-01227-5
https://doi.org/10.1186/s13148-022-01227-5
Autor:
Luisa N. Borrel, Esther Herrera-Luis, Angel C.Y. Mak, Maria Pino-Yanes, Kenneth B. Beckman, Fabián Lorenzo-Díaz, Javier Perez-Garcia, Esteban G. Burchard, Donglei Hu, Annie Li, Scott Huntsman, Kevin L. Keys, Celeste Eng
Publikováno v:
Molecular pathology and functional genomics.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::58c87c4002367ed6b2383b30faed7654
https://doi.org/10.1183/13993003.congress-2021.pa2389
https://doi.org/10.1183/13993003.congress-2021.pa2389