PKR is not obligatory for high-fat diet-induced obesity and its associated metabolic and inflammatory complications

Autor: G. I. Lancaster, H. L. Kammoun, M. J. Kraakman, G. M. Kowalski, C. R. Bruce, M. A. Febbraio

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)

Protein kinase R (PKR) has been suggested to act as a mediator of ER stress and inflammation in obesity. Here, Lancaster et al. find that genetic loss of PKR does not alter the development of obesity, and suggest that the use of littermate controls m

Externí odkaz: https://doaj.org/article/33a5a266327947a0a8bd5841e6f42498

Leptin-deficient obesity prolongs survival in a murine model of myelodysplastic syndrome

Autor: Michael J. Kraakman, Helene L. Kammoun, Dragana Dragoljevic, Annas Al-Sharea, Man K.S. Lee, Michelle C. Flynn, Christian J. Stolz, Andrew A. Guirguis, Graeme I. Lancaster, Jaye Chin-Dusting, David J. Curtis, Andrew J. Murphy

Publikováno v: Haematologica, Vol 103, Iss 4 (2018)

Obesity enhances the risk of developing myelodysplastic syndromes. However, the effect of obesity on survival is unclear. Obese people present with monocytosis due to inflammatory signals emanating from obese adipose tissue. We hypothesized that obes

Externí odkaz: https://doaj.org/article/737696cb60b3401b9c2f8491dfff23ce

Transient Intermittent Hyperglycemia Accelerates Atherosclerosis by Promoting Myelopoiesis

Autor: Raelene Pickering, Man K.S. Lee, Kyle L. Hoehn, Graeme I. Lancaster, Josephine M. Forbes, Michelle C Flynn, Ira J. Goldberg, Fiona Hortle, Ellen M. Olzomer, Tessa J. Barrett, Dragana Dragoljevic, Assam El-Osta, Domenica A. McCarthy, Merlin C. Thomas, Andrew J. Murphy, Frances L. Byrne, Edward A. Fisher, Liza Makowski, Nordin M J Hanssen, Annas Al-Sharea, Casper G. Schalkwijk, Helene L. Kammoun, Michael J Kraakman, Prabhakara R Nagareddy, Christos Tikellis, Mark E. Cooper

Publikováno v: Circulation Research, 127(7), 877-892. LIPPINCOTT WILLIAMS & WILKINS
Circ Res
Circulation research, 127(7), 877-892. Lippincott Williams and Wilkins

Rationale: Treatment efficacy for diabetes mellitus is largely determined by assessment of HbA1c (glycated hemoglobin A1c) levels, which poorly reflects direct glucose variation. People with prediabetes and diabetes mellitus spend >50% of their time

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::383655909ede56d0b90144cbbea30be5
https://doi.org/10.1161/circresaha.120.316653

The dual-specificity phosphatase 2 (DUSP2) does not regulate obesity-associated inflammation or insulin resistance in mice.

Autor: Graeme I Lancaster, Michael J Kraakman, Helene L Kammoun, Katherine G Langley, Emma Estevez, Ashish Banerjee, Raelene J Grumont, Mark A Febbraio, Steve Gerondakis

Publikováno v: PLoS ONE, Vol 9, Iss 11, p e111524 (2014)

Alterations in the immune cell profile and the induction of inflammation within adipose tissue are a hallmark of obesity in mice and humans. Dual-specificity phosphatase 2 (DUSP2) is widely expressed within the immune system and plays a key role prom

Externí odkaz: https://doaj.org/article/c6e9c3ba862d4d46b08bd8889f81e0b6

Fecal microbiota transplantation from high caloric-fed donors alters glucose metabolism in recipient mice, independently of adiposity or exercise status

Autor: Mark A. Febbraio, Tamara L Allen, Emma Estevez, Jessica P. S. Marshall, Mark Read, Darren C. Henstridge, Jereon Zoll, Sarah E Heywood, Helene L. Kammoun, Andrew J. Holmes

Publikováno v: American journal of physiology. Endocrinology and metabolism. 319(1)

Studies suggest the gut microbiota contributes to the development of obesity and metabolic syndrome. Exercise alters microbiota composition and diversity and is protective of these maladies. We tested whether the protective metabolic effects of exerc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d4c69744e708b92ae3d8cd1ae7ec76c
https://pubmed.ncbi.nlm.nih.gov/32516027