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of 25
pro vyhledávání: '"L. Joshua Leon"'
Publikováno v:
Cardiovascular Engineering. 4:149-153
Regardless of how it is initiated, the final stage of sudden cardiac death is ventricular fibrillation (VF), a completely disorganized electrical activity of the ventricles, characterized by multiple reentrant circuits. There is only one known therap
Publikováno v:
Chaos: An Interdisciplinary Journal of Nonlinear Science. 12:764-778
Atrial fibrillation (AF) is a common cardiac arrhythmia, but its mechanisms are incompletely understood. The identification of phase singularities (PSs) has been used to define spiral waves involved in maintaining the arrhythmia, as well as daughter
Autor:
Andre Bleau, L. Joshua Leon
Publikováno v:
Computer Vision and Image Understanding. 77:317-370
In recent years, the watershed line has emerged as the primary tool of mathematical morphology for image segmentation. Several very efficient algorithms have been devised for the determination of watersheds. Nevertheless, the application of watershed
Autor:
William L. Ditto, L. Joshua Leon, Wayne R. Giles, Robert B. Clark, Patricia A. Penkoske, Francis X. Witkowski, Mark L. Spano
Publikováno v:
Chaos: An Interdisciplinary Journal of Nonlinear Science. 8:94-102
The measurement of cardiac transmembrane potential changes with voltage sensitive dyes is in increasing use. Detection of these very small fluorescent alterations using large multiplexed arrays, such as charge coupled device (CCD) cameras at high sam
Publikováno v:
Annals of Biomedical Engineering. 24:662-674
A strand of cardiac muscle was modeled as a small bundle of individual fibers surrounded by a large volume conductor. The bundle is a uniform assembly of small identical cylindrical fibers, arranged as a series of concentric layers, and its behavior
Autor:
Francis X. Witkowski, L. Joshua Leon
Publikováno v:
Journal of Cardiovascular Electrophysiology. 6:379-390
Transmembrane Current Estimation. Introduction: A mathematical/computer model of cardiac tissue was used to study the estimation of transmembrane current (EIm) from extracellular potential recordings. Methods and Results: The simulated EIm of transme
Publikováno v:
The Canadian journal of cardiology. 29(9)
Background It has been suggested that more-complex fibrillation requires higher energy shocks to terminate. Furthermore, animal studies have demonstrated that shock timing also plays a role. The objective of this study was to test these assertions in
Autor:
L. Joshua Leon, Fernand A. Roberge
Publikováno v:
Journal of Electrocardiology. 25:69-79
The hypothesis of local circuit current flow underlying propagation of activation in cardiac muscle has been extensively documented by one-dimensional and two-dimensional simulation studies. The assumptions of spatially uniform membrane capacitance a
Publikováno v:
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference. 2009
Implantable cardioverter-defibrillaters (ICDs) are well known medical device for patients who are at a risk of sudden cardiac death caused by ventricular fibrillation (VF). The relationship between VF mechanisms and successful ICD therapy to terminat
Publikováno v:
Scopus-Elsevier
Simulations of cardiac bioelectric phenomena remain a significant challenge despite continual advancements in computational machinery. Spanning large temporal and spatial ranges demands millions of nodes to accurately depict geometry, and a comparabl