Zobrazeno 1 - 10
of 44
pro vyhledávání: '"L. Jordö"'
Publikováno v:
Acta Pharmacologica et Toxicologica. 36:45-58
The bioavailability, plasma levels and pharmacological effects of 100 mg of metoprolol tartrate administered as an ordinary tablet and as two different slow-release (SR) preparations were compared in healthy volunteers after single and multiple doses
Publikováno v:
British Journal of Clinical Pharmacology. 7:563-567
1. The plasma levels and the urinary excretion of hydrochlorothiazide (HCT) have been studied after administration of single doses of 12.5 and 25 mg of the drug in solution and in combination with 100 mg of the selective beta 1-adrenoreceptor antagon
Publikováno v:
European Journal of Clinical Pharmacology. 13:163-170
The selective β1-adrenoceptor agonist H 80/62 was administered intravenously and orally to healthy subjects and its effects on systolic time intervals, arterial blood pressure and heart rate were studied. Side-effects were noted too, and continuous
Publikováno v:
Clinical Pharmacokinetics. 5:181-191
Plasma concentration and urinary excretion of total and 2 active metabolites of metoprolol have been studied in patients with varying degrees of renal impairment and in healthy subjects after intravenous and oral administration of 20 and 50 mg of 3H-
Publikováno v:
Journal of Cardiovascular Pharmacology. 2:715-724
The pharmacokinetics of metoprolol and propranolol in 6 healthy volunteers were compared after an intravenous dose of 10 mg of each drug. The mean t1/2, beta was 3.6 hr for both drugs, but due to a larger volume of distribution, the total body cleara
Publikováno v:
Digestion. 11:183-193
The effect of various alcoholic beverages (ethanol, brandy, whisky, gin, and red wine) on hepatic triglyceride, phospholipid and cholesterol concentration, incorporation rate of glycerol into hepatic triglycerides and phospholipids and bile acid conj
Publikováno v:
Digestion. 7:204-211
Heparin has been shown to increase collagenolytic activity in bone and cause osteoporosis in man. In order to investigate if a similar collagenolytic activity could be induced in the liver and cause a dissolution of liver fibrosis, daily heparin inje
Publikováno v:
Journal of studies on alcohol. 36(9)
No pathological changes in the pancreas, kidneys or skeletal muscle were found in rats maintained for 8 to 9 months with a diet in which alcohol made up 50% of the total calories. An increase of the dietary fat content to 38% did not cause any fatty
Publikováno v:
Clinical pharmacokinetics. 5(2)
The pharmacokinetics of metoprolol have been studied in a group of patients with varying degrees of renal impairment and in healthy subjects after administration of 20 mg of metoprolol tartrate intravenously and 50 mg orally in a single dose and duri
Publikováno v:
International journal of clinical pharmacology, therapy, and toxicology. 18(7)
The bioavailability, plasma levels and pharmacological effect of a daily dose of 0.2 g of metoprolol in Durules and in regular 0.1 g tablets have been studied in eight healthy volunteers during steady state conditions. Durules and two 0.1 g metoprolo