Zobrazeno 1 - 10
of 22
pro vyhledávání: '"L. Jay Stallons"'
Autor:
Mark C. Heit, L. Jay Stallons, Wolfgang Seewald, Caryn M Thompson, Céline E. Toutain, Stephen B. King, Rainer Helbig
Publikováno v:
BMC Veterinary Research, Vol 16, Iss 1, Pp 1-13 (2020)
Abstract Background Robenacoxib (Onsior™) is a non-steroidal anti-inflammatory drug developed for canine and feline use for the control of pain and inflammation. It is available as both tablets and solution for injection. The objective of this stud
Externí odkaz:
https://doaj.org/article/752ef14942134320800018a14ac0231d
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e39596 (2012)
Y-family DNA-polymerases have larger active sites that can accommodate bulky DNA adducts allowing them to bypass these lesions during replication. One member, polymerase eta (pol eta), is specialized for the bypass of UV-induced thymidine-thymidine d
Externí odkaz:
https://doaj.org/article/1a48da194ab641dab5e8a7eda2f340b7
Autor:
L. Jay Stallons, W. Glenn McGregor
Publikováno v:
Journal of Nucleic Acids, Vol 2010 (2010)
A critical step in the transformation of cells to the malignant state of cancer is the induction of mutations in the DNA of cells damaged by genotoxic agents. Translesion DNA synthesis (TLS) is the process by which cells copy DNA containing unrepaire
Externí odkaz:
https://doaj.org/article/2ef65fb7423042cfadd147b218243de3
Autor:
Jennifer L. Harmon, Joseph L. Alge, Joshua E. Kneff, Craig Beeson, Jennifer J. Rahn, Rick G. Schnellmann, John M. Arthur, L. Jay Stallons, Sherine S.L. Chan, Ryan M. Whitaker
Publikováno v:
Kidney international
Recent studies show the importance of mitochondrial dysfunction in the initiation and progression of acute kidney injury (AKI). However, no biomarkers exist linking renal injury to mitochondrial function and integrity. To this end, we evaluated urina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::833a816f6f606ae01c0915f625e97b4c
http://europepmc.org/articles/PMC4675682
http://europepmc.org/articles/PMC4675682
Autor:
Lauren P. Wills, Rick G. Schnellmann, Craig Beeson, Judit Megyesi, L. Jay Stallons, Jason A. Funk, Sean R. Jesinkey
Publikováno v:
Journal of the American Society of Nephrology. 25:1157-1162
Mitochondrial biogenesis may be an adaptive response necessary for meeting the increased metabolic and energy demands during organ recovery after acute injury, and renal mitochondrial dysfunction has been implicated in the pathogenesis of AKI. We pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa533aaefc56c4e047238b2bc83f1db3
https://doi.org/10.1681/asn.2013090952
https://doi.org/10.1681/asn.2013090952
Publikováno v:
Toxicology Letters. 224:326-332
Acute kidney injury (AKI) is a disease with mitochondrial dysfunction and a newly established risk factor for the development of chronic kidney disease (CKD) and fibrosis. We examined mitochondrial homeostasis in the folic acid (FA)-induced AKI model
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d4a705cf3b035e34a6c360c5e21a350
https://doi.org/10.1016/j.toxlet.2013.11.014
https://doi.org/10.1016/j.toxlet.2013.11.014
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 347:626-634
Recent studies demonstrate that mitochondrial dysfunction is a mediator of acute kidney injury (AKI). Consequently, restoration of mitochondrial function after AKI may be key to the recovery of renal function. Mitochondrial function can be restored t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8ab30cd16fda08141b29a437b8d0d06
https://doi.org/10.1124/jpet.113.208017
https://doi.org/10.1124/jpet.113.208017
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 352(2)
Although disruption of mitochondrial homeostasis and biogenesis (MB) is a widely accepted pathophysiologic feature of sepsis-induced acute kidney injury (AKI), the molecular mechanisms responsible for this phenomenon are unknown. In this study, we ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef8c134088f3d47156d58e32dfd3e927
https://pubmed.ncbi.nlm.nih.gov/25503387
https://pubmed.ncbi.nlm.nih.gov/25503387
Publikováno v:
American journal of physiology. Renal physiology. 307(4)
While disruption of energy production is an important contributor to renal injury, metabolic alterations in sepsis-induced AKI remain understudied. We assessed changes in renal cortical glycolytic metabolism in a mouse model of sepsis-induced AKI. A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ae05b0c4bbde35866197b7df789a789
https://pubmed.ncbi.nlm.nih.gov/24990892
https://pubmed.ncbi.nlm.nih.gov/24990892
The kidneys compose approximately 0.5% of the body mass but consume about 10% of the oxygen in cellular respiration. This discordance is due to the high energy demands on the kidney for reabsorption of filtered blood components and makes the kidney s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eca7c275a3d8688cb1ed19ced70cd6c5
https://europepmc.org/articles/PMC3874592/
https://europepmc.org/articles/PMC3874592/
