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Akademický článek

Structural and dynamical description of the enzymatic reaction of a phosphohexomutase

Autor: Kyle M. Stiers, Abigail C. Graham, Jian-She Zhu, David L. Jakeman, Jay C. Nix, Lesa J. Beamer

Publikováno v: Structural Dynamics, Vol 6, Iss 2, Pp 024703-024703-11 (2019)

Enzymes are known to adopt various conformations at different points along their catalytic cycles. Here, we present a comprehensive analysis of 15 isomorphous, high resolution crystal structures of the enzyme phosphoglucomutase from the bacterium Xan

Externí odkaz: https://doaj.org/article/2abea1408cc848a6a4f80541b89e0f0e

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Synthesis of 5'-Thymidine-Conjugated Formylphenylboronic Acids as Potential Lysine Targeting Iminoboronate Reversible Covalent Enzyme Probes

Autor: Alana M. M. Rangaswamy, Michael H. R. Beh, Ebrahim Soleimani, Steve Sequeira, Julie Cormier, Katherine N. Robertson, David L. Jakeman

Publikováno v: The Journal of organic chemistry. 87(21)

The design of reversible-covalent molecules to selectively target the ε-amino functionality of lysine residues in enzymes or proteins is a highly desirable goal. Herein, we describe synthetic methodology used to prepare a series of 5'-thymidine-link

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdb4a1450a42f03cb02e1f63401ddf93
https://pubmed.ncbi.nlm.nih.gov/36265169

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Pilot study of jadomycin B pharmacokinetics and anti-tumoral effects in zebrafish larvae and mouse breast cancer xenograft models

Autor: Brendan T. McKeown, Nicholas J. Relja, Steven R. Hall, Simon Gebremeskel, Jeanna M. MacLeod, Chansey J. Veinotte, Leah G. Bennett, Leanne B. Ohlund, Lekha Sleno, David L. Jakeman, Jason N. Berman, Brent Johnston, Kerry B. Goralski

Publikováno v: Canadian journal of physiology and pharmacology.

Despite numerous therapeutic options, multidrug resistance (MDR) remains an obstacle to successful breast cancer therapy. Jadomycin B, a natural product derived from Streptomyces venezuelae ISP5230, maintains cytotoxicity in MDR human breast cancer c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c70c6903b80acd37bf861bf222a295d3
https://pubmed.ncbi.nlm.nih.gov/35985040

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A missense variant remote from the active site impairs stability of human phosphoglucomutase 1

Autor: Kelly N. Mason, Reed P. Hansen, Jian-She Zhu, Kyle M. Stiers, Bana A. Daghlas, Lesa J. Beamer, David L. Jakeman

Publikováno v: Journal of Inherited Metabolic Disease. 43:861-870

Missense variants of human phosphoglucomutase 1 (PGM1) cause the inherited metabolic disease known as PGM1 deficiency. This condition is categorised as both a glycogen storage disease and a congenital disorder of glycosylation. Approximately 20 misse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40f83f889a73dc52fbfd236f379aa639
https://doi.org/10.1002/jimd.12222

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On the Catalytic Activity of a GT1 Family Glycosyltransferase from Streptomyces venezuelae ISP5230

Autor: Stephanie M. Forget, Sydney B Shepard, Ebrahim Soleimani, David L. Jakeman

Publikováno v: The Journal of Organic Chemistry. 84:11482-11492

GT1 family glycosyltansferase, Sv0189, from Streptomyces venezuelae ISP5230 (ATCC 10721) was characterized. The recombinantly produced protein Sv0189 possessed UDP-glycosyltransferase activity. Screening, using an assay employing unnatural nitropheny

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::04b8f5adf710de439354e095f1307c2f
https://doi.org/10.1021/acs.joc.9b01130

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Inhibitory Evaluation of αPMM/PGM from Pseudomonas aeruginosa: Chemical Synthesis, Enzyme Kinetics, and Protein Crystallographic Study

Autor: Brandon R. Groves, Ebrahim Soleimani, Lesa J. Beamer, David L. Jakeman, Kyle M. Stiers, Jian-She Zhu

Publikováno v: The Journal of Organic Chemistry. 84:9627-9636

α-Phosphomannomutase/phosphoglucomutase (αPMM/PGM) from P. aeruginosa is involved in bacterial cell wall assembly and is implicated in P. aeruginosa virulence, yet few studies have addressed αPMM/PGM inhibition from this important Gram-negative ba

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5a63c2a5f8e248ebd098eba00844a745
https://doi.org/10.1021/acs.joc.9b01305

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Space-flight LiDARs, navigation, and science instrument implementations: lasers, optoelectronics, integrated photonics, fiber-optic subsystems, and components

Autor: W. Joe Thomes, Hali L. Jakeman, Eleanya Onuma, Cameron H. Parvini, Melanie N. Ott

Publikováno v: Photonic Instrumentation Engineering VII.

For the past 25 years, the National Aeronautics and Space Administration (NASA) Goddard Space Flight Center’s Photonics Group in the Engineering Directorate has been substantially contributing to the flight design, development, production, testing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::55b8e7776ed125f5f3ff9b8c21d97f23
https://doi.org/10.1117/12.2547352

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Enzymatic and structural characterization of HAD5, an essential phosphomannomutase of malaria-causing parasites

Autor: Philip M. Frasse, Justin J. Miller, Alexander J. Polino, Ebrahim Soleimani, Jian-She Zhu, David L. Jakeman, Joseph M. Jez, Daniel E. Goldberg, Audrey R. Odom John

Publikováno v: Journal of Biological Chemistry. 298:101550

The malaria-causing parasite Plasmodium falciparum is responsible for over 200 million infections and 400,000 deaths per year. At multiple stages during its complex life cycle, P. falciparum expresses several essential proteins tethered to its surfac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6376451ddb69094e06ea9b43f99b1b1
https://doi.org/10.1016/j.jbc.2021.101550

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