Zobrazeno 1 - 10
of 362
pro vyhledávání: '"L. Jackson Roberts"'
Autor:
Huan Tao, Jiansheng Huang, Patricia G. Yancey, Valery Yermalitsky, John L. Blakemore, Youmin Zhang, Lei Ding, Irene Zagol-Ikapitte, Fei Ye, Venkataraman Amarnath, Olivier Boutaud, John A. Oates, L. Jackson Roberts, Sean S. Davies, MacRae F. Linton
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Hypercholesterolemia is associated with lipid peroxidation induced reactive dicarbonyl adducts. Here the authors show that the dicarbonyl scavenger, 2-hydroxybenzylamine(2-HOBA), decreases reactive dicarbonyl modifications of LDL and HDL, improves HD
Externí odkaz:
https://doaj.org/article/1e1c9269b742425ab2397a10869c4faa
Autor:
Lisa M. Pitchford, Patricia M. Driver, John C. Fuller, Wendell S. Akers, Naji N. Abumrad, Venkataraman Amarnath, Ginger L. Milne, Sheau-Chiann Chen, Fei Ye, L. Jackson Roberts, M. Benjamin Shoemaker, John A. Oates, John A. Rathmacher, Olivier Boutaud
Publikováno v:
BMC Pharmacology and Toxicology, Vol 21, Iss 1, Pp 1-10 (2020)
Abstract Background 2-Hydroxybenzylamine (2-HOBA) is a selective dicarbonyl electrophile scavenger being developed as a nutritional supplement to help protect against the development of conditions associated with dicarbonyl electrophile formation, su
Externí odkaz:
https://doaj.org/article/aa4bb108a03440a0be1f206802adc5d2
Autor:
Lisa M. Pitchford, John A. Rathmacher, John C. Fuller, J. Scott Daniels, Ryan D. Morrison, Wendall S. Akers, Naji N. Abumrad, Venkataraman Amarnath, Patricia M. Currey, L. Jackson Roberts, John A. Oates, Olivier Boutaud
Publikováno v:
BMC Pharmacology and Toxicology, Vol 20, Iss 1, Pp 1-6 (2019)
Abstract Background 2-Hydroxybenzylamine (2-HOBA) is a selective scavenger of dicarbonyl electrophiles that protects proteins and lipids from being modified by these electrophiles. It is currently being developed for use as a nutritional supplement t
Externí odkaz:
https://doaj.org/article/7d1b0bf81dba4f70ab70f69755a8bc57
Autor:
Katherine Plewes, Hugh W.F. Kingston, Aniruddha Ghose, Richard J. Maude, M. Trent Herdman, Stije J. Leopold, Haruhiko Ishioka, Md. Mahtab Uddin Hasan, Md. Shafiul Haider, Shamsul Alam, Kim A. Piera, Prakaykaew Charunwatthana, Kamolrat Silamut, Tsin W. Yeo, Md. Abul Faiz, Sue J Lee, Mavuto Mukaka, Gareth D.H. Turner, Nicholas M. Anstey, L. Jackson Roberts, Nicholas J. White, Nicholas P.J. Day, Md. Amir Hossain, Arjen M. Dondorp
Publikováno v:
BMC Infectious Diseases, Vol 17, Iss 1, Pp 1-12 (2017)
Abstract Background Intravascular hemolysis is an intrinsic feature of severe malaria pathophysiology but the pathogenic role of cell-free hemoglobin-mediated oxidative stress in severe malaria associated acute kidney injury (AKI) is unknown. Methods
Externí odkaz:
https://doaj.org/article/006b9ebad5fe440481787ae037922499
Publikováno v:
Neurobiology of Disease, Vol 98, Iss , Pp 88-99 (2017)
Cognitive dysfunction is a major comorbidity of the epilepsies; however, treatments targeting seizure-associated cognitive dysfunction, particularly deficits in learning and memory are not available. Isoketals and neuroketals, collectively known as g
Externí odkaz:
https://doaj.org/article/7b7809f333204bfe9153813bebc72318
Autor:
William N. Beavers, Andrew J. Monteith, Venkataraman Amarnath, Raymond L. Mernaugh, L. Jackson Roberts, Walter J. Chazin, Sean S. Davies, Eric P. Skaar
Publikováno v:
mBio, Vol 10, Iss 5 (2019)
ABSTRACT Staphylococcus aureus infects every niche of the human host. In response to microbial infection, vertebrates have an arsenal of antimicrobial compounds that inhibit bacterial growth or kill bacterial cells. One class of antimicrobial compoun
Externí odkaz:
https://doaj.org/article/8d48f172b9184d079ef7539080bca2d8
Autor:
Christi T Salisbury-Ruf, Clinton C Bertram, Aurelia Vergeade, Daniel S Lark, Qiong Shi, Marlene L Heberling, Niki L Fortune, G Donald Okoye, W Gray Jerome, Quinn S Wells, Josh Fessel, Javid Moslehi, Heidi Chen, L Jackson Roberts II, Olivier Boutaud, Eric R Gamazon, Sandra S Zinkel
Publikováno v:
eLife, Vol 7 (2018)
Bcl-2 family proteins reorganize mitochondrial membranes during apoptosis, to form pores and rearrange cristae. In vitro and in vivo analysis integrated with human genetics reveals a novel homeostatic mitochondrial function for Bcl-2 family protein B
Externí odkaz:
https://doaj.org/article/713e95df63974051b6c65861bd7d12a1
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 7, Pp 1972-1979 (2013)
Despite animal and in vitro studies demonstrating pro-oxidative effects of Hg, previous human work showed no relationship between tissue Hg and plasma levels of F2-isoprostanes (IsoPs), a whole-body oxidative stress marker. We hypothesized that anoth
Externí odkaz:
https://doaj.org/article/fd449cd314c340a084307ab7a21b5eb5
Autor:
Youmin Zhang, Linda S. May-Zhang, L. Jackson Roberts, Sean S. Davies, Venkataraman Amarnath, Patricia G. Yancey, Jiansheng Huang, MacRae F. Linton, Lei Ding, Huan Tao, John A. Oates
Publikováno v:
Molecular Metabolism. 67:101651
ObjectiveOxidative stress contributes to the development of insulin resistance (IR) and atherosclerosis. Peroxidation of lipids produces reactive dicarbonyls such as Isolevuglandins (IsoLG) and malondialdehyde (MDA) that covalently bind plasma/cellul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6a8c678082182dc1bd35367affb68e9
https://doi.org/10.1016/j.molmet.2022.101651
https://doi.org/10.1016/j.molmet.2022.101651
Publikováno v:
Journal of Lipid Research, Vol 52, Iss 1, Pp 113-124 (2011)
15-Deoxy-Δ12,14-prostaglandin J2 (15-d-PGJ2) is a reactive cyclopentenone eicosanoid generated from the dehydration of cyclooxygenase-derived prostaglandin D2 (PGD2). This compound possesses an α,β-unsaturated carbonyl moiety that can readily addu
Externí odkaz:
https://doaj.org/article/7b82ac2cd0164f22a4752b850669f4ad