Zobrazeno 1 - 7
of 7
pro vyhledávání: '"L. J. Goutas"'
Publikováno v:
Cancer research. 41(11 Pt 1)
Information was sought on the relative extent to which transport-defective, methotrexate-resistant phenotypes emerge among the total subpopulation of resistant phenotypes during therapeutic challenge of leukemic cells in vivo. A number of monoclonal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3718d4a453215e8b6da7d40a77e01c69
https://pubmed.ncbi.nlm.nih.gov/7306968
https://pubmed.ncbi.nlm.nih.gov/7306968
Publikováno v:
Cancer research. 46(5)
Folylpolyglutamate hydrolase (folyl hydrolase) activity derived from murine tumors and various normal tissues was measured by means of high performance liquid chromatography using methotrexate polyglutamates as substrate. Enzyme-mediated hydrolysis w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b454de0daa7a6b6c9230d57362f05d85
https://pubmed.ncbi.nlm.nih.gov/2421872
https://pubmed.ncbi.nlm.nih.gov/2421872
Publikováno v:
Cancer Chemotherapy and Pharmacology. 12
A group of folate analogs of the 10-deaza-aminopterin series, which were designed on the basis of the results of an intensive biochemical and pharmacokinetic program, have been examined in therapy experiments utilizing a group of murine tumor models.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c6d212424b232476b1d623dba1b8fb63
https://doi.org/10.1007/bf00255904
https://doi.org/10.1007/bf00255904
Publikováno v:
Cancer Chemotherapy and Pharmacology. 12
Structural modification of the N10 position of 4-amino folates affects mediated membrane transport in mammalian cells but has little or no effect on target enzyme (dihydrofolate reductase) inhibition. Some of these modifications have been associated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee0e14838fd8967998dcb394ae3fa9ff
https://doi.org/10.1007/bf00255903
https://doi.org/10.1007/bf00255903
Publikováno v:
Cancer chemotherapy and pharmacology. 12(1)
A group of folate analogs of the 10-deaza-aminopterin series, which were designed on the basis of the results of an intensive biochemical and pharmacokinetic program, have been examined in therapy experiments utilizing a group of murine tumor models.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::934111ade6a49d6bffb5b41848461160
https://pubmed.ncbi.nlm.nih.gov/6690070
https://pubmed.ncbi.nlm.nih.gov/6690070
Publikováno v:
Cancer research. 42(3)
The M5076 murine "ovarian" tumor which is naturally refractive to methotrexate was found to be highly responsive to the lipophilic antifolate, metoprine. M5076 cells were markedly deficient in mediated entry of methotrexate. This was in contrast to t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9ee827a12c716d617ed74bf840d57d64
https://pubmed.ncbi.nlm.nih.gov/7059991
https://pubmed.ncbi.nlm.nih.gov/7059991
Autor:
F M, Sirotnak, L J, Goutas, D M, Jacobsen, L S, Mines, J R, Barrueco, Y, Gaumont, R L, Kisliuk
Publikováno v:
Biochemical pharmacology. 36(10)
Comparison of the kinetic parameters for influx of highly purified [3H]folic acid versus [3H]methotrexate in L1210 cells under anionic buffer conditions showed a marked discordancy. In addition, the kinetics for influx of [3H]folic acid were unchange
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::03b66d3185f5c427fd817a37b51ba9a1
https://pubmed.ncbi.nlm.nih.gov/3593392
https://pubmed.ncbi.nlm.nih.gov/3593392