Zobrazeno 1 - 10
of 27
pro vyhledávání: '"L. J. Coleman"'
Autor:
Margaret A. Mouat, Brendan P. Wilkins, Eileen Ding, Hemna Govindaraju, James L. J. Coleman, Robert M. Graham, Nigel Turner, Nicola J. Smith
Publikováno v:
Cells, Vol 11, Iss 11, p 1814 (2022)
Understanding the neurogenic causes of obesity may reveal novel drug targets to counter the obesity crisis and associated sequelae. Here, we investigate whether the deletion of GPR37L1, an astrocyte-specific orphan G protein-coupled receptor, affects
Externí odkaz:
https://doaj.org/article/d2ac150e46bc4892b1851a024e38dfe3
Autor:
Margaret A. Mouat, Kristy L. Jackson, James L. J. Coleman, Madeleine R. Paterson, Robert M. Graham, Geoffrey A. Head, Nicola J. Smith
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2021)
GPR37L1 is a family A orphan G protein-coupled receptor (GPCR) with a putative role in blood pressure regulation and cardioprotection. In mice, genetic ablation of Gpr37l1 causes sex-dependent effects; female mice lacking Gpr37l1 (GPR37L1−/−) hav
Externí odkaz:
https://doaj.org/article/9784a4b06c654138ba44b8698436d310
Autor:
James L. J. Coleman, Margaret A. Mouat, Jianxin Wu, Nikola Jancovski, Jaspreet K. Bassi, Andrea Y. Chan, David T. Humphreys, Nadine Mrad, Ze-Yan Yu, Tony Ngo, Siiri Iismaa, Cristobal G. dos Remedios, Michael P. Feneley, Andrew M. Allen, Robert M. Graham, Nicola J. Smith
Publikováno v:
Biology of Sex Differences, Vol 9, Iss 1, Pp 1-13 (2018)
Abstract Background Over 100 mammalian G protein-coupled receptors are yet to be matched with endogenous ligands; these so-called orphans are prospective drug targets for the treatment of disease. GPR37L1 is one such orphan, abundant in the brain and
Externí odkaz:
https://doaj.org/article/2b7afb49aad2427da3297516bb182039
Autor:
Nicola J. Smith, Sean S. So, Tony Ngo, Angela M. Finch, Kirti Kandhwal Chahal, Peter Keov, Brendan P. Wilkins, Irina Kufareva, James L. J. Coleman
Publikováno v:
Nat Chem Biol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df891f9dc76672dcd02854ff952ec73d
https://doi.org/10.1038/s41589-021-00748-z
https://doi.org/10.1038/s41589-021-00748-z
Autor:
Andrew J. Cleave, Nicola J. Smith, Robert M. Graham, James L. J. Coleman, Tony Ngo, Nicole M. Jones, Rhyll E. Smythe
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports
Scientific Reports
GPR37L1 is an orphan G protein-coupled receptor expressed exclusively in the brain and linked to seizures, neuroprotection and cardiovascular disease. Based upon the observation that fragments of the GPR37L1 N-terminus are found in human cerebrospina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::feb5ba07f9d9910725ce92c9d3ec6891
http://link.springer.com/article/10.1038/s41598-020-76384-9
http://link.springer.com/article/10.1038/s41598-020-76384-9
Involvement of GPR37L1 in murine blood pressure regulation and human cardiac disease pathophysiology
Autor:
Nicola J. Smith, Jianxin Wu, Michael P. Feneley, James L. J. Coleman, Robert M. Graham, Cristobal G. dos Remedios, Margaret A Mouat
Publikováno v:
American journal of physiology. Heart and circulatory physiology. 321(4)
This study characterizes systolic blood pressure (SBP) in a Gpr37l1 knockout mouse line, which was previously reported to have ∼60 mmHg higher SBP compared with a transgenic line. We observed only a ∼27 mmHg SBP difference between the lines. Howe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8aca0a5f2dc0a38f1699319c7a45fbff
https://pubmed.ncbi.nlm.nih.gov/34533400
https://pubmed.ncbi.nlm.nih.gov/34533400
Autor:
James L. J. Coleman, Karen eBrennan, Tony eNgo, Poornima eBalaji, Robert M. Graham, Nicola J Smith
Publikováno v:
Frontiers in Endocrinology, Vol 6 (2015)
As little as a decade ago, generation of a single knockout mouse line was an expensive and time-consuming undertaking available to relatively few researchers. The International Knockout Mouse Consortium, established in 2007, has revolutionized the us
Externí odkaz:
https://doaj.org/article/47796ed3547d4e1bba0fd4384e43edcc
Autor:
Irina Kufareva, Nicola J. Smith, Tony Ngo, Angela M. Finch, James L. J. Coleman, Peter Keov, Kirti Kandhwal Chahal, Brendan P. Wilkins, Sean S. So
Orphan G protein-coupled receptors (GPCRs) are largely intractable therapeutic targets, owing to the lack of chemical tools for exploring their pharmacology. The discovery of such tools, however, is hampered by a number of unknowns, such as effector
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2704b4103f0819716e7c470c59745416
https://doi.org/10.1101/2020.09.11.290486
https://doi.org/10.1101/2020.09.11.290486
Publikováno v:
Methods in Molecular Biology ISBN: 9781493923359
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::20f4032e60eeb5d7751bea76a89db3c5
https://doi.org/10.1007/978-1-4939-2336-6_20
https://doi.org/10.1007/978-1-4939-2336-6_20
Autor:
James L. J. Coleman, Tony Ngo, Johannes Schmidt, Nadine Mrad, Chu Kong Liew, Nicole M. Jones, Robert M. Graham, Nicola J. Smith
Publikováno v:
Science Signaling. 12
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::525515f3441b51e5e0dcf4c08efdff26
https://doi.org/10.1126/scisignal.aba2063
https://doi.org/10.1126/scisignal.aba2063