Zobrazeno 1 - 10
of 21
pro vyhledávání: '"L. J. Ashford"'
Autor:
Changwei Chen, Jennifer R Gallagher, Jamie Tarlton, Lidy van Aalten, Susan E Bray, Michael L J Ashford, Rory J McCrimmon, Ewan R Pearson, Alison D McNeilly, Calum Sutherland
Publikováno v:
PLoS ONE, Vol 16, Iss 7, p e0253533 (2021)
The biguanide, metformin, is the first-choice therapeutic agent for type-2 diabetes, although the mechanisms that underpin metformin clinical efficacy remain the subject of much debate, partly due to the considerable variation in patient response to
Externí odkaz:
https://doaj.org/article/9a24a180cc2645e98a6b2242015332ed
Autor:
G. A. Melvin, M. Freeman, L. J. Ashford, R. P. Hastings, D. Heyne, B. J. Tonge, T. Bailey, V. Totsika, K. M. Gray
Publikováno v:
Journal of Intellectual Disability Research, 67, 375-386. SAGE Publications
Background. It appears that students with intellectual disability (ID) are more frequently absent from schoolcompared with students without ID. The objective of the current study was to estimate the frequency ofabsence among students with ID and the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d0cff003249ff46cf6db8b567278828
https://doi.org/10.1111/jir.13011
https://doi.org/10.1111/jir.13011
Autor:
Paul J. Meakin, Anna Mezzapesa, Eva Benabou, Mary E. Haas, Bernadette Bonardo, Michel Grino, Jean-Michel Brunel, Christèle Desbois-Mouthon, Sudha B. Biddinger, Roland Govers, Michael L. J. Ashford, Franck Peiretti
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
A soluble form of insulin receptor in human plasma has been previously reported. Here the authors demonstrate that insulin receptor is cleaved by BACE1 that can regulate biological active insulin receptor levels in a glucose concentration-dependent m
Externí odkaz:
https://doaj.org/article/527a3cb8a7ee44ba84d8fe3536cdc213
Autor:
Paul J Meakin, Vicky L Morrison, Claire C Sneddon, Terhi Savinko, Liisa Uotila, Susan M Jalicy, Jennie L Gabriel, Li Kang, Michael L J Ashford, Susanna C Fagerholm
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0138872 (2015)
Beta2-integrins are important in leukocyte trafficking and function, and are regulated through the binding of cytoplasmic proteins, such as kindlin-3, to their intracellular domain. Here, we investigate the involvement of beta2-integrins in the regul
Externí odkaz:
https://doaj.org/article/a247e63f017248f79d5c40cb84987b44
Autor:
Julia M, Vlachaki Walker, Josephine L, Robb, Ana M, Cruz, Amrinder, Malhi, Paul G, Weightman Potter, Michael L J, Ashford, Rory J, McCrimmon, Kate L J, Ellacott, Craig, Beall
Publikováno v:
Diabetes, obesitymetabolism. 19(7)
To test the hypothesis that, given the role of AMP-activated protein kinase (AMPK) in regulating intracellular ATP levels, AMPK may alter ATP release from astrocytes, the main sources of extracellular ATP (eATP) within the brain.Measurements of ATP r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::79a2a2af5cbdf0c7857b5154730d37af
https://pubmed.ncbi.nlm.nih.gov/28211632
https://pubmed.ncbi.nlm.nih.gov/28211632
Autor:
Elizabeth, Haythorne, D Lee, Hamilton, John A, Findlay, Craig, Beall, Rory J, McCrimmon, Michael L J, Ashford
Publikováno v:
Neuropharmacology. 111
Individuals with Type 1 diabetes (T1D) are often exposed to recurrent episodes of hypoglycaemia. This reduces hormonal and behavioural responses that normally counteract low glucose in order to maintain glucose homeostasis, with altered responsivenes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c5f20fb376a31cece1ab29f03cba1cdb
https://pubmed.ncbi.nlm.nih.gov/27618741
https://pubmed.ncbi.nlm.nih.gov/27618741
Autor:
Louise, Reilly, Jacqueline, Howie, Krzysztof, Wypijewski, Michael L J, Ashford, Donald W, Hilgemann, William, Fuller
Publikováno v:
The FASEB Journal
The electrogenic Na/Ca exchanger (NCX) mediates bidirectional Ca movements that are highly sensitive to changes of Na gradients in many cells. NCX1 is implicated in the pathogenesis of heart failure and a number of cardiac arrhythmias. We measured NC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7ca64c29c5a936640fa090086e6ac519
https://pubmed.ncbi.nlm.nih.gov/26174834
https://pubmed.ncbi.nlm.nih.gov/26174834
Autor:
Krzysztof J, Wypijewski, Michele, Tinti, Wenzhang, Chen, Douglas, Lamont, Michael L J, Ashford, Sarah C, Calaghan, William, Fuller
Publikováno v:
Molecular & Cellular Proteomics : MCP
The lipid raft concept proposes that membrane environments enriched in cholesterol and sphingolipids cluster certain proteins and form platforms to integrate cell signaling. In cardiac muscle, caveolae concentrate signaling molecules and ion transpor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::61c9ab4c65e79bbabe04d0ad808fef8d
https://pubmed.ncbi.nlm.nih.gov/25561500
https://pubmed.ncbi.nlm.nih.gov/25561500
Autor:
Paul J, Meakin, Sudhir, Chowdhry, Ritu S, Sharma, Fiona B, Ashford, Shaun V, Walsh, Rory J, McCrimmon, Albena T, Dinkova-Kostova, John F, Dillon, John D, Hayes, Michael L J, Ashford
Publikováno v:
Molecular and Cellular Biology
Mice lacking the transcription factor NF-E2 p45-related factor 2 (Nrf2) develop more severe nonalcoholic steatohepatitis (NASH), with cirrhosis, than wild-type (Nrf2(+/+)) mice when fed a high-fat (HF) diet for 24 weeks. Although NASH is usually asso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d64756dc65c9535439ca62653e238545
https://pubmed.ncbi.nlm.nih.gov/24958099
https://pubmed.ncbi.nlm.nih.gov/24958099