Zobrazeno 1 - 10
of 285
pro vyhledávání: '"L. I. Gold"'
Distribution of transforming growth factor-β isoforms in human immunodeficiency virus-1 encephalitis
Autor:
Mahlon D. Johnson, L. I. Gold
Publikováno v:
Human Pathology. 27:643-649
The transforming growth factor-beta family of polypeptides includes three related isoforms with pervasive effects on immune system function. In this study, the authors evaluated human brains with human immunodeficiency virus (HIV)-1 encephalitis for
Autor:
D. F. Pierce, A. F. Purchio, L. I. Gold, S. D. Robinson, Yasuhisa Matsui, Brigid L.M. Hogan, C. W. Daniel, Harold L. Moses, Mahlon D. Johnson
Publikováno v:
Genes & Development. 7:2308-2317
The transforming growth factors beta (TGFs-beta) are potent inhibitors of cell proliferation and are usually secreted in a latent form. TGF-beta 1, TGF-beta 2, and TGF-beta 3 are expressed in distinct but overlapping patterns in the developing mouse
Publikováno v:
The Journal of Immunology. 151:1491-1499
"Classical" chemoattractants, such as FMLP, C5a, or leukotriene B4, not only elicit directed motility but also activate neutrophils (degranulation, release of active oxygen species). Signal transduction after ligation of receptors for these classical
Autor:
L Santambrogio, G M Hochwald, B Saxena, C H Leu, J E Martz, J A Carlino, N H Ruddle, M A Palladino, L I Gold, G J Thorbecke
Publikováno v:
The Journal of Immunology. 151:1116-1127
Experimental allergic encephalomyelitis (EAE) is an autoimmune disease in which peripheral lymphoid cells are activated by immunization with myelin proteins and become effector cells that traverse the central nervous system (CNS) capillaries and init
Publikováno v:
Diabetes. 42:746-756
Publikováno v:
Human Pathology. 24:457-462
The transforming growth factor-beta (TGF-beta) family of polypeptides includes three structurally and functionally related mammalian isoforms that influence cell proliferation, differentiation, and extracellular matrix production. Recent identificati
Publikováno v:
The Journal of Cell Biology
Isoform-specific antibodies to TGF beta 1, TGF beta 2, and TGF beta 3 proteins were generated and have been used to examine the expression of these factors in the developing mouse embryo from 12.5-18.5 d post coitum (d.p.c.). These studies demonstrat
Autor:
W Kepron, Ying Dong Xu, R O'Connor, N Antman, Nasreen Khalil, T Yehaulaeshet, T V Parekh, L I Gold
Publikováno v:
Thorax. 56(12)
Idiopathic pulmonary fibrosis (IPF) is characterised by subpleural fibrosis that progresses to involve all areas of the lung. The expression of transforming growth factor-beta1 (TGF-beta 1), a potent regulator of connective tissue synthesis, is incre
Publikováno v:
The Journal of pathology. 190(5)
The three mammalian isoforms of transforming growth factor-beta (TGF-beta1, -beta2, and -beta3) are potent regulators of cell growth, differentiation, and extracellular matrix deposition. To study their role in skin carcinogenesis, normal human kerat
Autor:
L I, Gold
Publikováno v:
Critical reviews in oncogenesis. 10(4)
Uncontrolled cellular proliferation is a hallmark of cancer. Thus, a relevant and important question is how cancer cells have escaped from normal growth regulatory mechanisms to become malignant and, further, what events favor progression and metasta