Zobrazeno 1 - 10
of 414
pro vyhledávání: '"L. Humm"'
Phase 1 study of intraventricular 131I-omburtamab targeting B7H3 (CD276)-expressing CNS malignancies
Autor:
Kim Kramer, Neeta Pandit-Taskar, Brian H. Kushner, Pat Zanzonico, John L. Humm, Ursula Tomlinson, Maria Donzelli, Suzanne L. Wolden, Sophia Haque, Ira Dunkel, Mark M. Souweidane, Jeffrey P. Greenfield, Satish Tickoo, Jason S. Lewis, Serge K. Lyashchenko, Jorge A. Carrasquillo, Bae Chu, Christopher Horan, Steven M. Larson, Nai-Kong V. Cheung, Shakeel Modak
Publikováno v:
Journal of Hematology & Oncology, Vol 15, Iss 1, Pp 1-12 (2022)
Abstract Background The prognosis for metastatic and recurrent tumors of the central nervous system (CNS) remains dismal, and the need for newer therapeutic targets and modalities is critical. The cell surface glycoprotein B7H3 is expressed on a rang
Externí odkaz:
https://doaj.org/article/efc8fef816994f42bd7ff478e4d20251
Autor:
Daniel Lafontaine, C. Ross Schmidtlein, Assen Kirov, Ryan P. Reddy, Simone Krebs, Heiko Schöder, John L. Humm
Publikováno v:
EJNMMI Physics, Vol 9, Iss 1, Pp 1-19 (2022)
Abstract Background An open-source, extensible medical viewing platform is described, called the TriDFusion image viewer (3DF). The 3DF addresses many broad unmet needs in nuclear medicine research; it provides a viewer with several tools not availab
Externí odkaz:
https://doaj.org/article/82cc686f45434b1abed576355ad04f67
Publikováno v:
EJNMMI Physics, Vol 8, Iss 1, Pp 1-14 (2021)
Abstract Background The goal of this work was to determine the quantitative accuracy and optimal reconstruction parameters for 124I-PET imaging in the presence of therapeutic levels of 131I. In this effort, images were acquired on a GE D710 PET/CT sc
Externí odkaz:
https://doaj.org/article/a14472fe533e4206b5ba237f0ac27677
Autor:
Sadek A. Nehmeh, Mohamed B. Moussa, Nancy Lee, Pat Zanzonico, Mithat Gönen, John L. Humm, Heiko Schöder
Publikováno v:
EJNMMI Research, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Purpose Glycolysis is increased by hypoxia, suggesting a possible correlation between the accumulation of 2-[18F]fluoro-2-deoxy-D-glucose (FDG) in malignant tumors and regional hypoxia defined by 1H-1-(3-[18F]fluoro-2-hydroxypropyl)-2-nitroi
Externí odkaz:
https://doaj.org/article/a8c6e901612b4ce4b7a454c9917b971c
Autor:
James Russell, Louise Fanchon, Hanan Alwaseem, Henrik Molina, Isabella O’Donoghue, Amber Bahr, Elisa deStanchina, Nagavarakishore Pillarsetty, John L. Humm
Publikováno v:
Pharmacology Research & Perspectives, Vol 10, Iss 2, Pp n/a-n/a (2022)
Abstract Previously published digital autoradiography of 3H‐labeled capecitabine reveals a near‐uniform distribution of activity throughout a murine pancreatic model. This is in contrast both to 14C‐labeled gemcitabine, and established expectat
Externí odkaz:
https://doaj.org/article/9a2617618920471fbdb6fb46405f3a90
Publikováno v:
PLoS ONE, Vol 17, Iss 4 (2022)
Purpose To devise a new body-habitus normalizer to be used in the calculation of an SUV that is specific to the PET tracer 18F-FDG. Methods A cohort of 481-patients was selected for analysis of 18F-FDG uptake into tissues unaffected by their disease.
Externí odkaz:
https://doaj.org/article/ee8c7f136a114cf9afd5e127bc57384a
Autor:
Kathryn R. Tringale, Suzanne L. Wolden, Matthias Karajannis, Sofia Haque, Luca Pasquini, Onur Yildirim, Marc Rosenblum, Jamal K. Benhamida, Nai-Kong Cheung, Mark Souweidane, Ellen M. Basu, Neeta Pandit-Taskar, Pat B. Zanzonico, John L. Humm, Kim Kramer
Publikováno v:
Journal of Neuro-Oncology. 162:69-78
Purpose Intraventricular compartmental radioimmunotherapy (cRIT) with 131-I-omburtamab is a potential therapy for recurrent primary brain tumors that can seed the thecal space. These patients often previously received external beam radiotherapy (EBRT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c706bec86b5874dc13074ada2ec0da44
https://doi.org/10.1007/s11060-022-04235-w
https://doi.org/10.1007/s11060-022-04235-w
Autor:
Louise M Fanchon, James Russell, Nagavarakishore Pillarsetty, Isabella O'Donoghue, Kishore Gangangari, Kenneth H Yu, John L Humm
Publikováno v:
PLoS ONE, Vol 15, Iss 4, p e0231745 (2020)
PurposeTo develop a technique to compare the intra-tumoral distribution of the drug gemcitabine, its surrogate [18F]-fluoroarabinocytosine ([18F]-FAC) and related chemotherapeutics 5-FU and capecitabine in a pre-clinical model of pancreatic ductal ad
Externí odkaz:
https://doaj.org/article/7adf9221d4bb4d8e964ed7d9acc68bdd
Publikováno v:
EJNMMI Research, Vol 8, Iss 1, Pp 1-4 (2018)
Abstract Background Quantitative imaging can facilitate patient stratification in clinical trials. The hypoxia-activated prodrug evofosfamide recently failed a phase III trial in pancreatic cancer. However, the study did not attempt to select for pat
Externí odkaz:
https://doaj.org/article/9677037b00144563a5848dafe17d01ee
Autor:
Carla Hajj, James Russell, Charles P Hart, Karyn A Goodman, Maeve A Lowery, Adriana Haimovitz-Friedman, Joseph O. Deasy, John L. Humm
Publikováno v:
Translational Oncology, Vol 10, Iss 5, Pp 760-765 (2017)
This study was designed to investigate the effect of single-dose radiation therapy (RT) in combination with evofosfamide (TH-302), a hypoxia-activated prodrug, in a pre-clinical model of pancreatic cancer. AsPC1 tumors were implanted orthotopically i
Externí odkaz:
https://doaj.org/article/cf346b6edb324199981a3b949a7dfb40