Zobrazeno 1 - 10
of 218
pro vyhledávání: '"L. Horwich"'
Publikováno v:
International Journal of Biological Macromolecules
The chaperonins (GroEL and GroES in Escherichia coli) are ubiquitous molecular chaperones that assist a subset of essential substrate proteins to undergo productive folding to the native state. Using single particle cryo EM and image processing we ha
Autor:
Urmi Bandyopadhyay, Justin Cotney, Maria Nagy, Sunghee Oh, Jing Leng, Milind Mahajan, Shrikant Mane, Wayne A Fenton, James P Noonan, Arthur L Horwich
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e53575 (2013)
Mechanisms involved with degeneration of motor neurons in amyotrophic lateral sclerosis (ALS; Lou Gehrig's Disease) are poorly understood, but genetically inherited forms, comprising ~10% of the cases, are potentially informative. Recent observations
Externí odkaz:
https://doaj.org/article/fd2b518e2af24c9c88b4ce99f30eed2f
Autor:
Arthur L. Horwich, Wayne A. Fenton
Publikováno v:
Quarterly Reviews of Biophysics. 53
This chronologue seeks to document the discovery and development of an understanding of oligomeric ring protein assemblies known as chaperonins that assist protein folding in the cell. It provides detail regarding genetic, physiologic, biochemical, a
Autor:
Arthur L. Horwich, Wayne A. Fenton, Sreeganga S. Chandra, Laura A. Volpicelli-Daley, Yumiko V. Taguchi, Maria Nagy, Erica L. Gorenberg, Drake R. Thrasher
Publikováno v:
Proc Natl Acad Sci U S A
Parkinson’s disease is characterized by the aggregation of the presynaptic protein α-synuclein and its deposition into pathologic Lewy bodies. While extensive research has been carried out on mediators of α-synuclein aggregation, molecular facili
Autor:
Yangshin Park, Anne-Marie Ray, Peter G. Schultz, Quyen Q. Hoang, Nilshad Salim, Steven M. Johnson, Andrew J. Ambrose, Najiba Mammadova, Corey M. Summers, Eli Chapman, Trent Kunkle, Mckayla Stevens, Sanofar Abdeen, Arthur L. Horwich
Publikováno v:
Journal of Medicinal Chemistry. 61:7345-7357
Extending from a study we recently published examining the anti-trypanosomal effects of a series of GroEL/ES inhibitors based on a pseudo-symmetrical bis-sulfonamido-2-phenylbenzoxazole scaffold, here, we report the antibiotic effects of asymmetric a
Autor:
Jiou Wang, George W Farr, David H Hall, Fei Li, Krystyna Furtak, Lars Dreier, Arthur L Horwich
Publikováno v:
PLoS Genetics, Vol 5, Iss 1, p e1000350 (2009)
The nature of toxic effects exerted on neurons by misfolded proteins, occurring in a number of neurodegenerative diseases, is poorly understood. One approach to this problem is to measure effects when such proteins are expressed in heterologous neuro
Externí odkaz:
https://doaj.org/article/19028e2c592640c78ed21b7639f3496c
Publikováno v:
The Journal of Neuroscience. 37:2258-2265
Mutations that alter levels of Slack (KCNT1) Na+-activated K+current produce devastating effects on neuronal development and neuronal function. We now find that Slack currents are rapidly suppressed by oligomers of mutant human Cu/Zn superoxide dismu
Autor:
Arthur L. Horwich
Publikováno v:
Molecular Biology of the Cell
Basic cellular research is a trail. One follows one’s nose toward what might be new understanding. When that leads to a need to employ unfamiliar or novel technology, it’s both exciting and very worthwhile to form collaborations. Our early studie
Autor:
Eli Chapman, Diane McMahon-Pratt, Arthur L. Horwich, Steven M. Johnson, Nilshad Salim, Najiba Mammadova, Peter G. Schultz, Sanofar Abdeen, Karen Goldsmith-Pestana, Corey M. Summers
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:5247-5253
Trypanosoma brucei are protozoan parasites that cause African sleeping sickness in humans (also known as Human African Trypanosomiasis-HAT). Without treatment, T. brucei infections are fatal. There is an urgent need for new therapeutic strategies as