Zobrazeno 1 - 10 of 31 pro vyhledávání: '"L. Hoefle"'
1
Study on the efficacy of dsRNAs with increasing length in RNAi-based silencing of the Fusarium CYP51 genes
Autor: L. Hoefle, Aline Koch, Lukas Jelonek, Bernhard Timo Werner, A. Shrestha
Previously, we have demonstrated that transgenic Arabidopsis and barley plants, expressing a 791 nucleotide (nt) dsRNA (CYP3RNA) that targets all three CYP51 genes (FgCYP51A, FgCYP51B, FgCYP51C) in Fusarium graminearum (Fg), inhibited fungal infectio
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3465ebb7166198eb9c7d723eb2695bfb
Zobrazit plný text záznamu
4
Inhibitors of acyl-CoA:cholesterol acyltransferase. 1. Identification and structure-activity relationships of a novel series of fatty acid anilide hypocholesterolemic agents
Autor: Ann Holmes, Bruce D. Roth, C. J. Blankley, Essenburg Ad, K.A. Kieft, W. H. Roark, R. L. Stanfield, Bharat K. Trivedi, Brian R. Krause, Milton L. Hoefle
Publikováno v: Journal of Medicinal Chemistry. 35:1609-1617
A series of fatty acid anilides was prepared, and compounds were tested for their ability to inhibit the enzyme acyl-CoA:cholesterol acyltransferase (ACAT) in vitro and to lower plasma total cholesterol and elevate high-density lipoprotein cholestero
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6e850c63582d3658c596051af28b574
https://doi.org/10.1021/jm00087a016
Zobrazit plný text záznamu
5
Conversion of NSAIDS into balanced dual inhibitors of cyclooxygenase and 5-lipoxygenase
Autor: Dirk A. Bornemeier, David T. Connor, Diane H. Boschelli, Milton L. Hoefle, Richard D. Dyer
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 2:69-72
By replacing the carboxylic acid functionality of several fenamates with 1,3,4-oxadiazole-2-thiones and 1,3,4-thiadiazole-2-thiones we converted selective cycloxygenase (CO) inhibitors ito dual inhibitors of both CO and 5-lipoxygenase (5-LO).
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b52c84813e12191fad55054145533988
https://doi.org/10.1016/s0960-894x(00)80657-5
Zobrazit plný text záznamu
6
Inhibitors of cholesterol biosynthesis. 1. trans-6-(2-Pyrrol-1-ylethyl)-4-hydroxypyran-2-ones, a novel series of HMG-CoA reductase inhibitors. 1. Effects of structural modifications at the 2- and 5-positions of the pyrrole nucleus
Autor: Michael William Wilson, Milton L. Hoefle, D. R. Sliskovic, Roger S. Newton, Bruce D. Roth, Charlotte D. Stratton, Daniel F. Ortwine
Publikováno v: Journal of Medicinal Chemistry. 33:21-31
A novel series of trans-6-(2-pyrrol-1-ylethyl)-4-hydroxypyran-2-ones and their dihydroxy acid derivatives were prepared and evaluated for their ability to inhibit the enzyme HMG-CoA reductase in vitro. A systematic study of substitution at the 2- and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1694558173f4f71e10bcba1d30878f3
https://doi.org/10.1021/jm00163a005
Zobrazit plný text záznamu
7
Synthesis and antiarrhythmic activity of alpha-[(diarylmethoxy)methyl]-1-piperidineethanols
Autor: Leslie M. Werbel, T. E. Mertz, C. S. Stratton, R. W. Fleming, T. J. Steffe, Stephen G. Hastings, L. T. Blouin, Milton L. Hoefle, J. M. Hinkley
Publikováno v: Journal of medicinal chemistry. 34(1)
A series of alpha-[(diarylmethoxy)methyl]-1-piperidineethanols was evaluated for antiarrhythmic activity in the coronary artery ligated dog model. Structure-activity relationship studies indicated that the 2,6-dimethylpiperidine group afforded the be
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf2380bf40f1b914b1bfd0dfb905b675
https://pubmed.ncbi.nlm.nih.gov/1992154
Zobrazit plný text záznamu
8
Inhibitors of cholesterol biosynthesis. 3. Tetrahydro-4-hydroxy-6-[2-(1H-pyrrol-1-yl)ethyl]-2H-pyran-2-one inhibitors of HMG-CoA reductase. 2. Effects of introducing substituents at positions three and four of the pyrrole nucleus
Autor: Bruce D. Roth, C. J. Blankley, Catherine Sekerke, E. Ferguson, A. W. Chucholowski, Milton L. Hoefle, Roger S. Newton, Charlotte D. Stratton, Daniel F. Ortwine, D. R. Sliskovic
Publikováno v: Journal of medicinal chemistry. 34(1)
A series of trans-tetrahydro-4-hydroxy-6-[2-(2,3,4,5-substituted-1H-pyrrol-1-yl) ethyl]-2H-pyran-2-ones and their dihydroxy acids were prepared and tested for their ability to inhibit the enzyme HMG-CoA reductase in vitro. Inhibitory potency was foun
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8cc1f80872bfb6e374a7d67e1aac12d
https://pubmed.ncbi.nlm.nih.gov/1992137
Zobrazit plný text záznamu
9
Synthesis and antiarrhythmic activity of cis-2,6-dimethyl-alpha,alpha-diaryl-1-piperidinebutanols
Autor: Milton L. Hoefle, R. W. Fleming, C. S. Stratton, T. E. Mertz, Stephen G. Hastings, T. J. Steffe, J. M. Hinkley, L. T. Blouin
Publikováno v: Journal of medicinal chemistry. 34(1)
A series of alpha,alpha-diaryl-1-piperidinebutanols was evaluated for antiarrhythmic activity in the coronary ligated dog model. Structure-activity relationship studies indicated that the 2,6-dimethylpiperidine group yielded compounds with the best a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::323324628858f116ba17616191eeccb8
https://pubmed.ncbi.nlm.nih.gov/1992110
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje