Zobrazeno 1 - 10
of 1 115
pro vyhledávání: '"L. Hecht"'
Publikováno v:
Trials, Vol 20, Iss 1, Pp 1-11 (2019)
Abstract Background The global prevalence of diabetes mellitus (DM) has been increasing over recent decades. In Germany, the prevalence for DM type 1 and type 2 in adults is estimated at about 7.7%. Hence, diabetes has to be classified as a serious p
Externí odkaz:
https://doaj.org/article/e20bfa1a5d48456b9e44f3fc65e115b2
Autor:
Amanda J. Martinot, Freek Cox, Peter Abbink, Jonathan L. Hecht, Roderick Bronson, Erica N. Borducchi, William J. Rinaldi, Melissa J. Ferguson, Rafael A. De La Barrera, Roland Zahn, Leslie van der Fits, Dan H. Barouch
Publikováno v:
npj Vaccines, Vol 9, Iss 1, Pp 1-12 (2024)
Abstract At the start of the Zika virus (ZIKV) epidemic in 2015, ZIKV spread across South and Central America, and reached parts of the southern United States placing pregnant women at risk for fetal microcephaly, fetal loss, and other adverse pregna
Externí odkaz:
https://doaj.org/article/7c72aa95122b4d95a6debb3275d3fe59
Autor:
Johanna M.S. Lemons, Maire Conrad, Ceylan Tanes, Jie Chen, Elliot S. Friedman, Manuela Roggiani, Dylan Curry, Lillian Chau, Aaron L. Hecht, Lisa Harling, Jennifer Vales, Kelly E. Kachelries, Robert N. Baldassano, Mark Goulian, Kyle Bittinger, Stephen R. Master, LinShu Liu, Gary D. Wu
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 17, Iss 1, Pp 131-148 (2024)
Background & Aims: Altered plasma acylcarnitine levels are well-known biomarkers for a variety of mitochondrial fatty acid oxidation disorders and can be used as an alternative energy source for the intestinal epithelium when short-chain fatty acids
Externí odkaz:
https://doaj.org/article/8f66c2b4eaed489691f98f9562d5b372
Autor:
Naoko Sasamoto, Paul A. Stewart, Tianyi Wang, Zachary J. Thompson, Sean J. Yoder, Jonathan L. Hecht, John L. Cleveland, Jose Conejo‐Garcia, Brooke L. Fridley, Kathryn L. Terry, Shelley S. Tworoger
Publikováno v:
Cancer Medicine, Vol 12, Iss 17, Pp 18405-18417 (2023)
Abstract Background Aspirin use has been associated with reduced ovarian cancer risk, yet the underlying biological mechanisms are not fully understood. To gain mechanistic insights, we assessed the association between prediagnosis low and regular‐
Externí odkaz:
https://doaj.org/article/4e60807f476e4be1828c4fc2a22e7d83
Autor:
Farnoosh Abbas-Aghababazadeh, Naoko Sasamoto, Mary K. Townsend, Tianyi Huang, Kathryn L. Terry, Allison F. Vitonis, Kevin M. Elias, Elizabeth M. Poole, Jonathan L. Hecht, Shelley S. Tworoger, Brooke L. Fridley
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
ObjectiveOptimal debulking with no macroscopic residual disease strongly predicts ovarian cancer survival. The ability to predict likelihood of optimal debulking, which may be partially dependent on tumor biology, could inform clinical decision-makin
Externí odkaz:
https://doaj.org/article/f58f5bf3c1a74cad896c1c704eef90af
Autor:
Amy E. Leader, Michelle Miller-Day, Rikishi T. Rey, Preethi Selvan, Anne E. Pezalla, Michael L. Hecht
Publikováno v:
Preventive Medicine Reports, Vol 29, Iss , Pp 101920- (2022)
Rates of human papillomavirus (HPV) infection are highest in young adults, who can be vaccinated against HPV if they were not vaccinated as adolescents. Since young adults increasingly access health information on social media, we tested the impact o
Externí odkaz:
https://doaj.org/article/ea3db97f17444938b588904679018250
Autor:
Na Wang, Marta Vuerich, Ahmadreza Kalbasi, Jonathon J. Graham, Eva Csizmadia, Zachary James Manickas-Hill, Ann Woolley, Clement David, Eric M. Miller, Kara Gorman, Jonathan L. Hecht, Shahzad Shaefi, Simon C. Robson, Maria Serena Longhi
Publikováno v:
iScience, Vol 24, Iss 10, Pp 103205- (2021)
Summary: T cell exhaustion and dysfunction are hallmarks of severe COVID-19. To gain insights into the pathways underlying these alterations, we performed a comprehensive transcriptome analysis of peripheral-blood-mononuclear-cells (PBMCs), spleen, l
Externí odkaz:
https://doaj.org/article/03da945e58204d69bd6bcc6513eaad77
Autor:
Cassandra A. Hathaway, Jose R. Conejo-Garcia, Brooke L. Fridley, Bernard Rosner, Daryoush Saeed-Vafa, Carlos Moran Segura, Jonathan V. Nguyen, Jonathan L. Hecht, Naoko Sasamoto, Kathryn L. Terry, Shelley S. Tworoger, Mary K. Townsend
Publikováno v:
Cancer Epidemiology, Biomarkers & Prevention. 32:848-853
Background: Despite the immunogenic nature of many ovarian tumors, treatment with immune checkpoint therapies has not led to substantial improvements in ovarian cancer survival. To advance population-level research on the ovarian tumor immune microen
Autor:
Eun-Young, Kang, Ashley, Weir, Nicola S, Meagher, Kyo, Farrington, Gregg S, Nelson, Prafull, Ghatage, Cheng-Han, Lee, Marjorie J, Riggan, Adelyn, Bolithon, Gordana, Popovic, Betty, Leung, Katrina, Tang, Neil, Lambie, Joshua, Millstein, Jennifer, Alsop, Michael S, Anglesio, Beyhan, Ataseven, Ellen, Barlow, Matthias W, Beckmann, Jessica, Berger, Christiani, Bisinotto, Hans, Bösmüller, Jessica, Boros, Alison H, Brand, Angela, Brooks-Wilson, Sara Y, Brucker, Michael E, Carney, Yovanni, Casablanca, Alicia, Cazorla-Jiménez, Paul A, Cohen, Thomas P, Conrads, Linda S, Cook, Penny, Coulson, Madeleine, Courtney-Brooks, Daniel W, Cramer, Philip, Crowe, Julie M, Cunningham, Cezary, Cybulski, Kathleen M, Darcy, Mona A, El-Bahrawy, Esther, Elishaev, Ramona, Erber, Rhonda, Farrell, Sian, Fereday, Anna, Fischer, María J, García, Simon A, Gayther, Aleksandra, Gentry-Maharaj, C Blake, Gilks, Marcel, Grube, Paul R, Harnett, Shariska Petersen, Harrington, Philipp, Harter, Arndt, Hartmann, Jonathan L, Hecht, Sebastian, Heikaus, Alexander, Hein, Florian, Heitz, Joy, Hendley, Brenda Y, Hernandez, Susanna Hernando, Polo, Sabine, Heublein, Akira, Hirasawa, Estrid, Høgdall, Claus K, Høgdall, Hugo M, Horlings, David G, Huntsman, Tomasz, Huzarski, Andrea, Jewell, Mercedes, Jimenez-Linan, Michael E, Jones, Scott H, Kaufmann, Catherine J, Kennedy, Dineo, Khabele, Felix K F, Kommoss, Roy F P M, Kruitwagen, Diether, Lambrechts, Nhu D, Le, Marcin, Lener, Jenny, Lester, Yee, Leung, Anna, Linder, Liselore, Loverix, Jan, Lubiński, Rashna, Madan, G Larry, Maxwell, Francesmary, Modugno, Susan L, Neuhausen, Alexander, Olawaiye, Siel, Olbrecht, Sandra, Orsulic, José, Palacios, Celeste Leigh, Pearce, Malcolm C, Pike, Carmel M, Quinn, Ganendra Raj, Mohan, Cristina, Rodríguez-Antona, Matthias, Ruebner, Andy, Ryan, Stuart G, Salfinger, Naoko, Sasamoto, Joellen M, Schildkraut, Minouk J, Schoemaker, Mitul, Shah, Raghwa, Sharma, Yurii B, Shvetsov, Naveena, Singh, Gabe S, Sonke, Linda, Steele, Colin J R, Stewart, Karin, Sundfeldt, Anthony J, Swerdlow, Aline, Talhouk, Adeline, Tan, Sarah E, Taylor, Kathryn L, Terry, Aleksandra, Tołoczko, Nadia, Traficante, Koen K, Van de Vijver, Maaike A, van der Aa, Toon, Van Gorp, Els, Van Nieuwenhuysen, Lilian, van-Wagensveld, Ignace, Vergote, Robert A, Vierkant, Chen, Wang, Lynne R, Wilkens, Stacey J, Winham, Anna H, Wu, Javier, Benitez, Andrew, Berchuck, Francisco J, Candido Dos Reis, Anna, DeFazio, Peter A, Fasching, Ellen L, Goode, Marc T, Goodman, Jacek, Gronwald, Beth Y, Karlan, Stefan, Kommoss, Usha, Menon, Hans-Peter, Sinn, Annette, Staebler, James D, Brenton, David D, Bowtell, Paul D P, Pharoah, Susan J, Ramus, Martin, Köbel
Publikováno v:
Cancer, 129(5), 697-713. Wiley
Cancer: interdisciplinary international journal of the American Cancer Society
Cancer: interdisciplinary international journal of the American Cancer Society
BACKGROUND: Cyclin E1 (CCNE1) is a potential predictive marker and therapeutic target in tubo-ovarian high-grade serous carcinoma (HGSC). Smaller studies have revealed unfavorable associations for CCNE1 amplification and CCNE1 overexpression with sur
Autor:
Heather H. Burris, Allan C. Just, Miriam J. Haviland, Dayna T. Neo, Andrea A. Baccarelli, Alexandra E. Dereix, Kasey J. Brennan, Rodosthenis S. Rodosthenous, Steven J. Ralston, Jonathan L. Hecht, Michele R. Hacker
Publikováno v:
Epigenetics, Vol 13, Iss 7, Pp 742-750 (2018)
Infants born preterm are at increased risk of multiple morbidities and mortality. Why some women deliver preterm remains poorly understood. Prior studies have shown that cervical microRNA expression and DNA methylation are associated with the length
Externí odkaz:
https://doaj.org/article/7bd1de72dc194a01992a01b61f47f5ff