Zobrazeno 1 - 10
of 1 296
pro vyhledávání: '"L. Hartley"'
Autor:
Laura Xicota, Lam-Ha T. Dang, Alice Lee, Sharon Krinsky-McHale, Deborah Pang, Lisa Melilli, Sid O'Bryant, Rachel L. Henson, Charles Laymon, Florence Lai, H. Diana Rosas, Beau Ances, Ira Lott, Christy Hom, Bradley Christian, Sigan Hartley, Shahid Zaman, Elizabeth Head, Mark Mapstone, Zhezhen Jin, Wayne Silverman, Nicole Schupf, Benjamin Handen, Joseph H. Lee, Howard J. Aizenstein, Beau M. Ances, Howard F. Andrews, Karen Bell, Rasmus Birn, Adam M. Brickman, Peter Bulova, Amrita Cheema, Kewei Chen, Bradley T. Christian, Isabel Clare, Lorraine Clark, Ann D. Cohen, John N. Constantino, Eric W. Doran, Anne Fagan, Eleanor Feingold, Tatiana M. Foroud, Benjamin L. Handen, Jordan Harp, Sigan L. Hartley, Rachel Henson, Lawrence Honig, Milos D. Ikonomovic, Sterling C. Johnson, Courtney Jordan, M.Ilyas Kamboh, David Keator, William E. Klunk, Julia K. Kofler, William Charles Kreisl, Sharon J. Krinsky-McHale, Patrick Lao, Ira T. Lott, Victoria Lupson, Chester A. Mathis, Davneet Singh Minhas, Neelesh Nadkarni, Sid O’Bryant, Melisa Parisi, Melissa Pettersen, Julie C. Price, Margaret Pulsifer, Michael S. Rafii, Eric Reiman, Batool Rizvi, Laurie Ryan, Frederick Schmitt, Wayne P. Silverman, Dana L. Tudorascu, Rameshwari Tumuluru, Benjamin Tycko, Badri Varadarajan, Desiree A. White, Michael A. Yassa, Fan Zhang
Publikováno v:
EBioMedicine, Vol 110, Iss , Pp 105433- (2024)
Summary: Background: Individuals with Down syndrome (DS) are at high risk of early-onset Alzheimer's disease (AD); yet, some 20 percent do not develop any signs of dementia until after 65 years or in their lifetime. Mosaicism could contribute to this
Externí odkaz:
https://doaj.org/article/7bcbc45f9a5e40b7ab0502504ef1c084
Autor:
Emily K. Schworer, Benjamin L. Handen, Melissa Petersen, Sid O'Bryant, Jamie C. Peven, Dana L. Tudorascu, Laisze Lee, Sharon J. Krinsky‐McHale, Christy L. Hom, Isabel C. H. Clare, Bradley T. Christian, Nicole Schupf, Joseph H. Lee, Elizabeth Head, Mark Mapstone, Ira Lott, Beau M. Ances, Shahid Zaman, Adam M. Brickman, Florence Lai, H. Diana Rosas, Sigan L. Hartley, the Alzheimer Biomarker Consortium‐Down Syndrome
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 16, Iss 2, Pp n/a-n/a (2024)
Abstract INTRODUCTION People with Down syndrome (DS) have a 75% to 90% lifetime risk of Alzheimer's disease (AD). AD pathology begins a decade or more prior to onset of clinical AD dementia in people with DS. It is not clear if plasma biomarkers of A
Externí odkaz:
https://doaj.org/article/13dbf3a21419485bb2909612d2c5af23
Publikováno v:
Frontiers in Psychiatry, Vol 14 (2024)
IntroductionWithin two-parent households, the parent-couple subsystem (marital or romantic partner relationship) is posited to shape the mental health of both parents and children. Autistic children and their parents have an elevated-risk for mental
Externí odkaz:
https://doaj.org/article/876ffdec9d994b7181aed41ef693f2dd
Autor:
Phillip J. Wallace, Dominique D. Gagnon, Geoffrey L. Hartley, Michael J. Taber, Stephen S. Cheung
Publikováno v:
Physiological Reports, Vol 11, Iss 24, Pp n/a-n/a (2023)
Abstract This study tested the effects of skin and core cooling on cognitive function in 0°C cold air. Ten males completed a randomized, repeated measures study consisting of four environmental conditions: (i) 30 min of exposure to 22°C thermoneutr
Externí odkaz:
https://doaj.org/article/5bceabcc6b904e34bad5b621886dcce9
Autor:
Marcus S. Noel, Semmie Kim, Marion L. Hartley, Steve Wong, Vincent J. Picozzi, Harry Staszewski, Dae Won Kim, Jan M. Van Tornout, Philip Agop Philip, Vincent Chung, Allyson J. Ocean, Andrea Wang‐Gillam
Publikováno v:
Cancer Medicine, Vol 11, Iss 22, Pp 4169-4181 (2022)
Abstract Background This trial explores SM‐88 used with methoxsalen, phenytoin, and sirolimus (MPS) in pretreated metastatic pancreatic ductal adenocarcinoma (mPDAC) Methods Forty‐nine patients were randomized to daily 460 or 920 mg oral SM‐88
Externí odkaz:
https://doaj.org/article/566d5c8953714e0c95e07051f157b1d7
Publikováno v:
Current Oncology, Vol 29, Iss 10, Pp 6864-6892 (2022)
Pancreatic adenocarcinoma remains one of the most lethal cancers globally, with a significant need for improved therapeutic options. While the recent breakthroughs of immunotherapy through checkpoint inhibitors have dramatically changed treatment par
Externí odkaz:
https://doaj.org/article/e0de4312d2d74fea9aa43dc2880ffe95
Autor:
Reetu Mukherji, Chao Yin, Rumaisa Hameed, Ali Z. Alqahtani, Monika Kulasekaran, Aiwu R. He, Benjamin A. Weinberg, John L. Marshall, Marion L. Hartley, Marcus S. Noel
Publikováno v:
Biology Direct, Vol 17, Iss 1, Pp 1-22 (2022)
Abstract This is a review of the current state of molecular profiling in gastrointestinal (GI) cancers and what to expect from this evolving field in the future. Individualized medicine is moving from broad panel testing of numerous genes or gene pro
Externí odkaz:
https://doaj.org/article/098ade47519e4a5193785c2b1e40b3a5
Autor:
Jamie C. Peven, Benjamin L. Handen, Charles M. Laymon, Victoria Fleming, Brianna Piro-Gambetti, Bradley T. Christian, William Klunk, Ann D. Cohen, Ozioma Okonkwo, Sigan L. Hartley
Publikováno v:
Frontiers in Integrative Neuroscience, Vol 16 (2022)
Higher engagement in moderate-intensity physical activity (PA) is related to better cognitive functioning in neurotypical adults; however, little is known about the effect of PA on cognitive aging in adults with Down syndrome (DS). Individuals with D
Externí odkaz:
https://doaj.org/article/df0cac8f510d40ab84c6748acd4a3dd0
Autor:
Austin M. Bazydlo, Matthew D. Zammit, Minjie Wu, Patrick J. Lao, Douglas C. Dean, III, Sterling C. Johnson, Dana L. Tudorascu, Ann Cohen, Karly A. Cody, Beau Ances, Charles M. Laymon, William E. Klunk, Shahid Zaman, Benjamin L. Handen, Sigan L. Hartley, Andrew L. Alexander, Bradley T. Christian
Publikováno v:
NeuroImage: Clinical, Vol 33, Iss , Pp 102908- (2022)
Introduction: Individuals with Down syndrome (DS) are at an increased risk of developing Alzheimer’s Disease (AD). One of the early underlying mechanisms in AD pathology is the accumulation of amyloid protein plaques, which are deposited in extrace
Externí odkaz:
https://doaj.org/article/158dd7b6ead14a7fb884d639927e63a9
Autor:
Ricardo Schultz Martins, Phillip J. Wallace, Scott W. Steele, Jake S. Scott, Michael J. Taber, Geoffrey L. Hartley, Stephen S. Cheung
Publikováno v:
Frontiers in Psychology, Vol 12 (2021)
Increases in body temperature from heat stress (i.e., hyperthermia) generally impairs cognitive function across a range of domains and complexities, but the relative contribution from skin versus core temperature changes remains unclear. Hyperthermia
Externí odkaz:
https://doaj.org/article/a75524dad16b496b9708d173377a2dee