SMIFH2 inhibition of platelets demonstrates a critical role for formin proteins in platelet cytoskeletal dynamics

Autor: Hannah L. H. Green, Steven G. Thomas, Malou Zuidscherwoude, Christopher W Smith, Fawaz Obaidullah Alenazy, Markus Bender

Publikováno v: Journal of Thrombosis and Haemostasis

Background Reorganization of the actin cytoskeleton is required for proper functioning of platelets following activation in response to vascular damage. Formins are a family of proteins that regulate actin polymerization and cytoskeletal organization

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a55087ef015387fa69d765b30f8cc00a
https://doi.org/10.1111/jth.14735

Dysregulation of 2-oxoglutarate-dependent dioxygenases by hyperglycaemia: does this link diabetes and vascular disease?

Autor: Alison C. Brewer, Hannah L. H. Green

Publikováno v: Clinical Epigenetics

The clinical, social and economic burden of cardiovascular disease (CVD) associated with diabetes underscores an urgency for understanding the disease aetiology. Evidence suggests that the hyperglycaemia associated with diabetes is, of itself, causal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::691e0293dc8870fd6e4d46f22e45ec60
https://doi.org/10.1186/s13148-020-00848-y

L-selectin: A Major Regulator of Leukocyte Adhesion, Migration and Signaling

Autor: Samuel James Hart, Aleksandar Ivetic, Hannah L. H. Green

Publikováno v: Frontiers in Immunology
Frontiers in Immunology, Vol 10 (2019)

L-selectin (CD62L) is a type-I transmembrane glycoprotein and cell adhesion molecule that is expressed on most circulating leukocytes. Since its identification in 1983, L-selectin has been extensively characterized as a tethering/rolling receptor. Th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0942d3cdb0c75486f20bad8e715d007
https://doi.org/10.3389/fimmu.2019.01068

Investigations into the reactivity of lithium indenyl with alpha diimines with chlorinated backbones and formation of related functional ligands and metal complexes

Autor: Sofia I. Pascu, Mark E. Fischer, Chi Tien Chen, Ino C. Vei, Caroline Windsor, David G. Calatayud, Malcolm L. H. Green

Publikováno v: Chen, C T, Fischer, M E, Windsor, C, Vei, I C, Calatayud, D G, Green, M L H & Pascu, S I 2016, ' Investigations into the reactivity of lithium indenyl with alpha diimines with chlorinated backbones and formation of related functional ligands and metal complexes ', Polyhedron, vol. 119, pp. 532-547 . https://doi.org/10.1016/j.poly.2016.09.021

Reaction between lithium indenyl and a chlorine substituted alpha diimine of the form [{Cl(NPh)2}C)]2 unexpectedly yielded the corresponding NH rearranged derivative [PhN(H)C(C9H6)]2 (1) rather than the predicted symmetrical α-diimine. This compound

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6182f557e3a405993c5667e63403ced
https://doi.org/10.1016/j.poly.2016.09.021

Comment on 'Hydride, gold(i) and related derivatives of the unsaturated ditungsten anion [W

Autor: Malcolm L H, Green

Publikováno v: Dalton transactions (Cambridge, England : 2003). 47(18)

Application of the covalent bond classification to the compounds [M2(η5-C5H5)2(μ-H)(μ-PCy2)(CO)2] (M = Mo, W) identifies the compounds as having two M-M bonds and a 2 electron 3 centre (2e-3c) bond incorporating the bridging hydrogen, in accord wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::56c45c305333a44ce87d53b3b3ad9052
https://pubmed.ncbi.nlm.nih.gov/29691529