Výsledky vyhledávání

Dendritic cells for active immunotherapy: Optimizing design and manufacture in order to develop commercially and clinically viable products

Autor: Theresa L. Whiteside, Irina Y. Tcherepanova, Charles A. Nicolette, Donald Healey, Tamara Monesmith, L. H. Finke, F. Miesowicz, P. Whelton, L. Coombs

Publikováno v: Vaccine. 25:B47-B60

Dendritic cell (DC) active immunotherapy is potentially efficacious in a broad array of malignant disease settings. However, challenges remain in optimizing DC-based therapy for maximum clinical efficacy within manufacturing processes that permit qua

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82b3bf5e885f27085a42a9e1c1d576f3
https://doi.org/10.1016/j.vaccine.2007.06.006

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Secretory Type II Phospholipase A2 (PLA2G2A) expression status in colorectal carcinoma derived cell lines and in normal colonic mucosa

Autor: Manfred Schwab, Christian Praml, L. H. Finke, Susanne Dihlmann, Peter M. Schlag, Lukas C. Amler

Publikováno v: Oncogene. 17:2009-2012

There is good evidence now that the secretory type II phospholipase A2 (Pla2g2a) gene represents the Mom1 locus, a genetic modifier of tumor resistance in the multiple intestinal neoplasia (Min) mouse. Previously we have mapped the human homolog PLA2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29da646d4db357fca4a16fcddb80485f
https://doi.org/10.1038/sj.onc.1202121

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Integrins and E-Cadherin Expression – A Way for the Better Understanding of the Biological Behaviour of Colorectal Cancer

Autor: Ch. Zörb, L. H. Finke, H.-J. Terpe, Peter M. Schlag

Publikováno v: Oncology Research and Treatment. 20:48-52

Colorectal carcinoma ranks second in frequency among all malignant tumors in the developed industrial countries. Determination of tumor cell differentiation together with pathological and clinical staging are currently the most important prognostic m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0dee7af1f52c3f7b48e715dda5342365
https://doi.org/10.1159/000218896

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Amplification of satellite DNA at 16q11.2 in the germ-line of a patient with breast-cancer

Autor: Manfred Schwab, Larissa Savelyeva, Peter M. Schlag, L. H. Finke, B. Schneider

Publikováno v: International journal of oncology. 4(2)

Cytogenetic analyses of peripheral blood cells of breast cancer patients unveiled in one case a grossly enlarged G-band in one copy of chromosome 16 (16qh+), which scored also strongly positive in C-banding. Fluorescence in situ hybridization with bo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddbc6536adf12591334ed223b44ed10f
https://pubmed.ncbi.nlm.nih.gov/21566930

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Immunologic activity and safety of autologous HIV RNA-electroporated dendritic cells in HIV-1 infected patients receiving antiretroviral therapy

Autor: Mohamed Rachid Boulassel, Oleg Yegorov, Irina Y. Tcherepanova, Rafick Pierre Sekaly, Tamara Monesmith, Don Healey, Claire Landry, Charles A. Nicolette, Bader Yassine-Diab, Renu Jain, L. H. Finke, Jean-Pierre Routy

Publikováno v: Clinical immunology (Orlando, Fla.). 134(2)

Immunogenicity, manufacturing feasibility, and safety of a novel, autologous dendritic cell (DC)-based immunotherapy (AGS-004) was evaluated in ten human immunodeficiency virus type 1 (HIV-1)-infected adults successfully treated with antiretroviral t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f2feb58baae9cbf8383c2c52cf513c4
https://pubmed.ncbi.nlm.nih.gov/19889582

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Improving the efficacy of cancer immunotherapy

Autor: Rolf Kiessling, Cedrik M. Britten, Leif Håkansson, G. Gaudernack, Heinz Zwierzina, Angus G. Dalgleish, K. Kallen, M. Schuessler-Lenz, John Copier, Sacha Gnjatic, James E. Talmadge, H. Singh, L. H. Finke

Publikováno v: European journal of cancer (Oxford, England : 1990). 45(8)

A series of cancer vaccines have been evaluated in clinical trials with encouraging results, but the demonstration of clinical benefit in confirmatory studies has so far proven to be difficult. The development of cancer vaccines is hampered by a rang

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ba1e5b851f4738521cac0f8bc366008
https://pubmed.ncbi.nlm.nih.gov/19167214

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Lessons from randomized phase III studies with active cancer immunotherapies--outcomes from the 2006 meeting of the Cancer Vaccine Consortium (CVC)

Autor: Brent A. Blumenstein, Axel Hoos, Kerry Wentworth, Natalie S. Rudolph, Hyam I. Levitsky, L. H. Finke

Publikováno v: Vaccine. 25

After years of effort to develop active cancer immunotherapies, seven candidate products achieved promising results in phase I/II studies that triggered phase III randomized studies. One candidate to date has received an approvable letter from the Un

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a172d7156495ac71853483c25625ad61
https://pubmed.ncbi.nlm.nih.gov/17916465

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Expression of CD44 standard and isoforms in human breast cancer xenografts and shedding of soluble forms into serum of nude mice

Autor: I, Fichtner, A, Dehmel, H, Naundorf, L H, Finke

Publikováno v: Anticancer research. 17(5A)

Standard CD44 (CD44s) and variant isoforms (CD44v) are expressed on different malignant cells and tissues. Their upregulation has been implicated, in the progression and metastasis of malignomas. In this work we addressed the question of whether thes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e21099377e4c3b6a0b93bb967c5be06e
https://pubmed.ncbi.nlm.nih.gov/9413216

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