Zobrazeno 1 - 10 of 770 pro vyhledávání: '"L. Gunderson"'
1
Akademický článek
Mutations in α-synuclein, TDP-43 and tau prolong protein half-life through diminished degradation by lysosomal proteases
Autor: Paul J. Sampognaro, Shruti Arya, Giselle M. Knudsen, Emma L. Gunderson, Angelica Sandoval-Perez, Molly Hodul, Kathryn Bowles, Charles S. Craik, Matthew P. Jacobson, Aimee W. Kao
Publikováno v: Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-22 (2023)
Abstract Background Autosomal dominant mutations in α-synuclein, TDP-43 and tau are thought to predispose to neurodegeneration by enhancing protein aggregation. While a subset of α-synuclein, TDP-43 and tau mutations has been shown to increase the
Externí odkaz: https://doaj.org/article/e9dcb181060f4b0d9dcfbc703faec0a4
Zobrazit plný text záznamu
3
Akademický článek
The endosymbiont Wolbachia rebounds following antibiotic treatment.
Autor: Emma L Gunderson, Ian Vogel, Laura Chappell, Christina A Bulman, K C Lim, Mona Luo, Jeffrey D Whitman, Chris Franklin, Young-Jun Choi, Emilie Lefoulon, Travis Clark, Brenda Beerntsen, Barton Slatko, Makedonka Mitreva, William Sullivan, Judy A Sakanari
Publikováno v: PLoS Pathogens, Vol 16, Iss 7, p e1008623 (2020)
Antibiotic treatment has emerged as a promising strategy to sterilize and kill filarial nematodes due to their dependence on their endosymbiotic bacteria, Wolbachia. Several studies have shown that novel and FDA-approved antibiotics are efficacious a
Externí odkaz: https://doaj.org/article/f89eb62492fe42fa95aecba52589d24f
Zobrazit plný text záznamu
4
Akademický článek
Pyrvinium Pamoate and Structural Analogs Are Early Macrofilaricide Leads
Autor: Emma L. Gunderson, Clifford Bryant, Christina A. Bulman, Chelsea Fischer, Mona Luo, Ian Vogel, Kee-Chong Lim, Shabnam Jawahar, Nancy Tricoche, Denis Voronin, Christopher Corbo, Rene B. Ayiseh, Faustin P. T. Manfo, Glory E. Mbah, Fidelis Cho-Ngwa, Brenda Beerntsen, Adam R. Renslo, Sara Lustigman, Judy A. Sakanari
Publikováno v: Pharmaceuticals, Vol 15, Iss 2, p 189 (2022)
Onchocerciasis and lymphatic filariasis are neglected tropical diseases caused by infection with filarial worms. Annual or biannual mass drug administration with microfilaricidal drugs that kill the microfilarial stages of the parasites has helped re
Externí odkaz: https://doaj.org/article/47f08033f00a440f8fc6a2eb661e1414
Zobrazit plný text záznamu
6
Cysteine Oxidation in Proteins: Structure, Biophysics, and Simulation
Autor: Diego Garrido Ruiz, Angelica Sandoval-Perez, Amith Vikram Rangarajan, Emma L. Gunderson, Matthew P. Jacobson
Publikováno v: Biochemistry, vol 61, iss 20
Cysteine side chains can exist in distinct oxidation states depending on the pH and redox potential of the environment, and cysteine oxidation plays important yet complex regulatory roles. Compared with the effects of post-translational modifications
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7edd8a0a65eeda2c564b562a19357ab8
https://doi.org/10.1021/acs.biochem.2c00349
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje