Zobrazeno 1 - 10
of 46
pro vyhledávání: '"L. Grice"'
Autor:
Paul J. Lehner, Frank McCaughan, Edward J.D. Greenwood, Thomas W.M. Crozier, Wenrui Guo, James C. Williamson, Ildar Gabaev, Linsey M. Porter, Guinevere L. Grice, Ana Teixeira-Silva, Richard J. Stanton, Arthur Wickenhagen, Sam J. Wilson, Eddie C. Y. Wang, James A. Nathan, Nicholas J. Matheson
Publikováno v:
Wellcome Open Research, Vol 7 (2022)
Background: Quantitative proteomics is able to provide a comprehensive, unbiased description of changes to cells caused by viral infection, but interpretation may be complicated by differential changes in infected and uninfected ‘bystander’ cells
Externí odkaz:
https://doaj.org/article/ebbb57c2f26649a4b38fb103c69777b6
Autor:
Husvinee Sundaramurthi, Sarah L. Roche, Guinevere L. Grice, Ailis Moran, Eugene T. Dillion, Giuseppe Campiani, James A. Nathan, Breandán N. Kennedy
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Blindness arising from retinal or macular degeneration results in significant social, health and economic burden. While approved treatments exist for neovascular (‘wet’) age-related macular degeneration, new therapeutic targets/interventions are
Externí odkaz:
https://doaj.org/article/2e185917117c4d43933d36f98b9d58b0
Autor:
George Carnell, James A. Nathan, Jessica Gronlund, Mina Paloniemi, Jakub Luptak, Paul Tonks, Sumita Pai, Soraya Ebrahimi, David A. Wells, Sara Lear, Leo C. James, Lourdes Ceron-Gutierrez, Rainer Döffinger, Helen Baxendale, Jonathan L. Heeney, John A. G. Briggs, Ashleigh Sayer, Angalee Nadesalingham, Guinevere L. Grice, Xiaoli Ziong
Publikováno v:
The Journal of Critical Care Medicine
The Journal of Critical Care Medicine, Vol 7, Iss 3, Pp 199-210 (2021)
The Journal of Critical Care Medicine, Vol 7, Iss 3, Pp 199-210 (2021)
Introduction In early 2020, at first surge of the coronavirus disease 2019 (COVID-19) pandemic, many health care workers (HCW) were re-deployed to critical care environments to support intensive care teams looking after patients with severe COVID-19.
The Proteasome Distinguishes between Heterotypic and Homotypic Lysine-11-Linked Polyubiquitin Chains
Autor:
Guinevere L. Grice, Ian T. Lobb, Michael P. Weekes, Steven P. Gygi, Robin Antrobus, James A. Nathan
Publikováno v:
Cell Reports, Vol 12, Iss 4, Pp 545-553 (2015)
Proteasome-mediated degradation occurs with proteins principally modified with lysine-48 polyubiquitin chains. Whether the proteasome also can bind atypical ubiquitin chains, including those linked by lysine-11, has not been well established. This is
Externí odkaz:
https://doaj.org/article/19a9ef90879149569c8496f5afdac613
Autor:
Eleanor Minogue, Pedro P. Cunha, Alessandro Quaranta, Javier Zurita, Shiv Sah Teli, Brennan J. Wadsworth, Rob Hughes, Guinevere L. Grice, Pedro Velica, David Bargiela, Laura Barbieri, Craig E. Wheelock, James A. Nathan, Peppi Koivunen, Iosifina P. Foskolou, Randall S. Johnson
T cell function is influenced by several metabolites; some acting through enzymatic inhibition of α-KG-dependent dioxygenases (αKGDDs), others, through post-translational modification of lysines in important targets. We show here that glutarate, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::538efc706f989d5ebc17f27fe7005cec
https://doi.org/10.1101/2022.10.20.513065
https://doi.org/10.1101/2022.10.20.513065
Publikováno v:
eLife, Vol 6 (2017)
Hypoxia Inducible transcription Factors (HIFs) are principally regulated by the 2-oxoglutarate and Iron(II) prolyl hydroxylase (PHD) enzymes, which hydroxylate the HIFα subunit, facilitating its proteasome-mediated degradation. Observations that HIF
Externí odkaz:
https://doaj.org/article/17b5963dc2be4395a5d3592f77ec8cf3
Akademický článek
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Autor:
Amy L. Grice
Publikováno v:
Equine Veterinary Education. 35:60-61
Autor:
Rainer Doffinger, Jonathan L. Heeney, S. Pai, J. Gronlund, Leo C. James, A. Sayer, John A. G. Briggs, Soraya Ebrahimi, Helen Baxendale, James A. Nathan, Lourdes Ceron-Gutierrez, Xiaoli Xiong, Jakub Luptak, Paul Tonks, M. Paloniemi, Angalee Nadesalingam, David A. Wells, Guinevere L. Grice, George Carnell
With the first 2020 surge of the COVID-19 pandemic, many health care workers (HCW) were re-deployed to critical care environments to support intensive care teams to look after high numbers of patients with severe COVID-19. There was considerable anxi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38569d413671ad0422358d6e87147fe0
Autor:
James A. Nathan, Guinevere L. Grice
Publikováno v:
Cellular and Molecular Life Sciences
The ability of ubiquitin to form up to eight different polyubiquitin chain linkages generates complexity within the ubiquitin proteasome system, and accounts for the diverse roles of ubiquitination within the cell. Understanding how each type of ubiq