Zobrazeno 1 - 10
of 197
pro vyhledávání: '"L. Goebel"'
Publikováno v:
JACS Au, Vol 4, Iss 4, Pp 1436-1449 (2024)
Externí odkaz:
https://doaj.org/article/daf34c1e07fe4dec99751c6fc3a64d97
Publikováno v:
Trends in Pharmacological Sciences. 43:866-881
Kinases are among the most successful drug targets. To date, 72 small-molecule kinase inhibitors (SMKIs) have been approved by the US FDA, together with ~500 SMKIs in clinical trials. Although the topic has been heavily reviewed in recent years, an o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6e3b1c2e25d962d9890ec1c8d797882
https://doi.org/10.1016/j.tips.2022.04.006
https://doi.org/10.1016/j.tips.2022.04.006
Publikováno v:
ChemBioChem.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::325d95ed377de7ed93e721def7bc25bb
https://doi.org/10.1002/cbic.202300168
https://doi.org/10.1002/cbic.202300168
Autor:
Pascal Hommen, Jimin Hwang, Peng Wu, Lydia Borgelt, Sonja Sievers, Georg L. Goebel, Fu Li, Philipp Lampe
Publikováno v:
ACS Medicinal Chemistry Letters. 12:893-898
Modulation of protein-RNA interaction (PRI) using small molecules is a promising strategy to develop therapeutics. LIN28 is an RNA-binding protein that blocks the maturation of the tumor suppressor let-7 microRNAs. Herein, we performed a fluorescence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f7b7b073d51cec684d57ed902e5a7c4a
https://doi.org/10.1021/acsmedchemlett.0c00546
https://doi.org/10.1021/acsmedchemlett.0c00546
Autor:
S. Schrenker, M. Cucchiarini, L. Goebel, T. Oláh, J.K. Venkatesan, G. Schmitt, S. Speicher-Mentges, J. Maihöfer, L. Gao, D. Zurakowski, M.D. Menger, M.W. Laschke, H. Madry
Publikováno v:
Osteoarthritis and cartilage.
Osteoarthritis (OA) is a serious consequence of focal osteochondral defects. Gene transfer of human transforming growth factor beta (hTGF-β) with recombinant adeno-associated virus (rAAV) vectors offers a strategy to improve osteochondral repair. Ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6438db5724113a37081563495d7014bd
https://pubmed.ncbi.nlm.nih.gov/36481450
https://pubmed.ncbi.nlm.nih.gov/36481450
Autor:
Peter J.S. Franks, Emanuele Di Lorenzo, Nicole L. Goebel, Fanny Chenillat, Pascal Rivière, Christopher A. Edwards, Arthur J. Miller
Publikováno v:
Oceanography, Vol 26, Iss 3, Pp 26-33 (2013)
Understanding the effects of climate change on planktonic ecosystems requires the synthesis of large, diverse data sets of variables that often interact in nonlinear ways. One fruitful approach to this synthesis is the use of numerical models. Here,
Externí odkaz:
https://doaj.org/article/62e4f5c8475c47fa9096842c672bff91
Autor:
Xiaqiu Qiu, Lydia Borgelt, Georg L. Goebel, Peng Wu, Helen L. Lightfoot, Pascal Hommen, Lisa Hohnen
Publikováno v:
European journal of medicinal chemistry. 228
Inhibition of the RNA-binding protein LIN28 and disruption of the protein–RNA interaction of LIN28–let-7 with small molecules holds great potential to develop new anticancer therapeutics. Herein, we report the LIN28 inhibitory activities of a ser
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f83d1854ff09891f0c7be3b1544a453
https://pubmed.ncbi.nlm.nih.gov/34883291
https://pubmed.ncbi.nlm.nih.gov/34883291
Akademický článek
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Autor:
Lydia, Borgelt, Fu, Li, Pascal, Hommen, Philipp, Lampe, Jimin, Hwang, Georg L, Goebel, Sonja, Sievers, Peng, Wu
Publikováno v:
ACS Medicinal Chemistry Letters
Modulation of protein–RNA interaction (PRI) using small molecules is a promising strategy to develop therapeutics. LIN28 is an RNA-binding protein that blocks the maturation of the tumor suppressor let-7 microRNAs. Herein, we performed a fluorescen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dd1c4bdb465d01c8581dd39d5c095fac
https://pubmed.ncbi.nlm.nih.gov/34136077
https://pubmed.ncbi.nlm.nih.gov/34136077
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
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