Skewed X chromosomal inactivation impacts T regulatory cell function in systemic sclerosis

Autor: Mjh Coenen, Timothy R D J Radstake, L. Geurts-van Bon, J.C.A. Broen, Anthonie Willem Langerak, Robert Lafyatis, Madelon C. Vonk, I.L.M. Wolvers-Tettero

Publikováno v: Annals of the Rheumatic Diseases, 69, 12, pp. 2213-6
Annals of the Rheumatic Diseases, 69(12), 2213-2216. BMJ Publishing Group
Annals of the Rheumatic Diseases, 69, 2213-6

ObjectivesTo investigate the role of X chromosomal inactivation (XCI) in systemic sclerosis (SSc) and its effects on forkhead box P3 (Foxp3) expression in T regulatory cells (Tregs).Methods217 women with SSc and 107 healthy women (controls) were incl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1134b145d2452fd0642a3fe74059010
https://hdl.handle.net/2066/89215

Skewed X-chromosomal inactivation impacts T regulatory cell function in systemic sclerosis

Autor: Robert Lafyatis, L. Geurts-van Bon, Madelon C. Vonk, Anthonie Willem Langerak, Timothy R D J Radstake, Mjh Coenen, I.L.M. Wolvers-Tettero, J.C.A. Broen

Publikováno v: Journal of Translational Medicine
Journal of Translational Medicine, Vol 8, Iss Suppl 1, p O7 (2010)

OBJECTIVES: > To investigate the role of X chromosomal inactivation (XCI) in systemic sclerosis (SSc) and its effects on forkhead box P3 (Foxp3) expression in T regulatory cells (Tregs). METHODS: 217 women with SSc and 107 healthy women (controls) we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fdc7c2ed6cfac9199319c4f49327731
https://doi.org/10.1186/1479-5876-8-s1-o7

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Variants of PBEF predispose to systemic sclerosis and pulmonary arterial hypertension development

Autor: Madelon C. Vonk, P. Airo, L. Beretta, Ariane L. Herrick, Roger Hesselstrand, Norberto Ortego-Centeno, R. Scorza, L. Geurts-van Bon, Maureen D. Mayes, M. A. Gonzalez-Gay, Pravitt Gourh, C. Brouwer, Diego Kyburz, Bo R. Rueda, C. P. Simeon, Gabriela Riemekasten, Patricia Carreira, V. Fonollosa, J. C. A. Broen, Frank C. Arnett, Javier Martin, N. Hunzelman, Fabienne Niederer, Hans P. Kiener, Jane Worthington, Denton C. Fonseca, M. J. H. Coenen, Trdj Radstake

Publikováno v: Annals of the Rheumatic Diseases. 70:A19-A19

Aim Pre-B cell colony-enhancing factor (PBEF) is intricately involved in inflammation and fibrosis, functional polymorphisms of PBEF have been previously shown to influence PBEF expression and pulmonary damage. Systemic sclerosis (SSc) is a disease i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1e292fe1d2f9ff3553ef1f220ee28595
https://doi.org/10.1136/ard.2010.148965.15

Variants of PBEF predispose to systemic sclerosis and pulmonary arterial hypertension development

Autor: Hans P. Kiener, Bo R. Rueda, V. Fonollosa, Roger Hesselstrand, Patricia Carreira, C. P. Simeon, Javier Martin, Maureen D. Mayes, Gabriela Riemekasten, J. C. A. Broen, Ariane L. Herrick, Christopher P. Denton, N. Hunzelman, L. Geurts-van Bon, Pravitt Gourh, Frank C. Arnett, Jane Worthington, Norberto Ortego-Centeno, Carmen Fonseca, Diego Kyburz, C. Brouwer, F Niederer, M. J. H. Coenen, Madelon C. Vonk, L. Beretta, Trdj Radstake, M. A. Gonzalez-Gay, R. Scorza, P. Airo

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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Journal of Translational Medicine, Vol 8, Iss Suppl 1, p P46 (2010)
Journal of Translational Medicine

2 páginas.-- Póster presentado al 5º European Workshop on Immune-Mediated Inflammatory Diseases celebrado en Sitges (Barcelona, España) del 1 al 3 de Diciembre de 2010.-- et al.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c858ce0b0dc0370650e7b3d0db4acc9