Immunometabolic Signatures Predict Risk of Progression to Active Tuberculosis and Disease Outcome

Autor: Fergal J. Duffy, January Weiner, Scott Hansen, David L. Tabb, Sara Suliman, Ethan Thompson, Jeroen Maertzdorf, Smitha Shankar, Gerard Tromp, Shreemanta Parida, Drew Dover, Michael K. Axthelm, Jayne S. Sutherland, Hazel M. Dockrell, Tom H. M. Ottenhoff, Thomas J. Scriba, Louis J. Picker, Gerhard Walzl, Stefan H. E. Kaufmann, Daniel E. Zak, The GC6-74 Consortium, S. H. E. Kaufmann, S. K. Parida, R. Golinski, J. Maertzdorf, J. Weiner, M. Jacobson, G. McEwen, G. Walzl, G. F. Black, G. van der Spuy, K. Stanley, M. Kriel, N. Du Plessis, N. Nene, A. G. Loxton, N. N. Chegou, S. Suliman, T. Scriba, M. Fisher, H. Mahomed, J. Hughes, K. Downing, A. Penn-Nicholson, H. Mulenga, B. Abel, M. Bowmaker, B. Kagina, W. Kwong, C. W. Hanekom, T. H. M. Ottenhoff, M. R. Klein, M. C. Haks, K. L. Franken, A. Geluk, K. E. van Meijgaarden, S. A. Joosten, D. van Baarle, F. Miedema, W. H. Boom, B. Thiel, J. Sadoff, D. Sizemore, S. Ramachandran, L. Barker, M. Brennan, F. Weichold, S. Muller, L. Geiter, G. Schoolnik, G. Dolganov, T. Van, H. Mayanja-Kizza, M. Joloba, S. Zalwango, M. Nsereko, B. Okwera, H. Kisingo, H. M. Dockrell, S. Smith, P. Gorak-Stolinska, Y.-G. Hur, M. Lalor, J.-S. Lee, A. C. Crampin, N. French, B. Ngwira, A. B. Smith, K. Watkins, L. Ambrose, F. Simukonda, H. Mvula, F. Chilongo, J. Saul, K. Branson, D. Kassa, A. Abebe, T. Mesele, B. Tegbaru, R. Howe, A. Mihret, A. Aseffa, Y. Bekele, R. Iwnetu, M. Tafesse, L. Yamuah, M. Ota, J. Sutherland, P. Hill, R. Adegbola, T. Corrah, M. Antonio, T. Togun, I. Adetifa, S. Donkor, P. Andersen, I. Rosenkrands, M. Doherty, K. Weldingh

Publikováno v: Frontiers in Immunology, Vol 10 (2019)

There remains a pressing need for biomarkers that can predict who will progress to active tuberculosis (TB) after exposure to Mycobacterium tuberculosis (MTB) bacterium. By analyzing cohorts of household contacts of TB index cases (HHCs) and a string

Externí odkaz: https://doaj.org/article/1eba36dc045c44aa95b786e37918a63e

A phase IIb, open-label, randomized controlled dose ranging multi-centre trial to evaluate the safety, tolerability, pharmacokinetics and exposure-response relationship of different doses of delpazolid in combination with bedaquiline delamanid moxifloxacin in adult subjects with newly diagnosed, uncomplicated, smear-positive, drug-sensitive pulmonary tuberculosis

Autor: A Dierig, M Hoelscher, S Schultz, L Hoffmann, A Jarchow-MacDonald, EM Svensson, L Te Brake, R Aarnoutse, M Boeree, TD McHugh, LM Wildner, X Gong, PPJ Phillips, LT Minja, N Ntinginya, S Mpagama, A Liyoyo, RS Wallis, M Sebe, FA Mhimbira, B Mbeya, M Rassool, L Geiter, YL Cho, N Heinrich

Publikováno v: Trials, Vol 24, Iss 1, Pp 1-15 (2023)

Abstract Background Linezolid is an effective, but toxic anti-tuberculosis drug that is currently recommended for the treatment of drug-resistant tuberculosis. Improved oxazolidinones should have a better safety profile, while preserving efficacy. De

Externí odkaz: https://doaj.org/article/265f0f479ac94f85a50582a8b628b59c

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

A New Recombinant Bacille Calmette‐Guérin Vaccine Safely Induces Significantly Enhanced Tuberculosis‐Specific Immunity in Human Volunteers

Autor: Azra Blazevic, Getahun Abate, Jorge H. Soler, Daniel F. Hoft, Marcus A. Horwitz, L. Geiter, Gilla Kaplan, Jerald C. Sadoff, Willem A. Hanekom, Frank Weichold

Publikováno v: The Journal of Infectious Diseases. 198:1491-1501

One third of the world’s population is infected with M. tuberculosis, and 2 million tuberculosis (TB) deaths occur annually (http://www.who.int/gtb/publications/globrep01/index.html). These staggering statistics persist despite the availability of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dd861bb837a524f77435b8d4b7a2ab1c
https://doi.org/10.1086/592450

Predictive factors for latent tuberculosis infection among adolescents in a high-burden area in South Africa

Autor: H, Mahomed, T, Hawkridge, S, Verver, L, Geiter, M, Hatherill, D-A, Abrahams, R, Ehrlich, W A, Hanekom, G D, Hussey

Publikováno v: The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease. 15(3)

A high tuberculosis (TB) burden area in South Africa (notification rate for all TB cases 1400 per 100 000 population).To determine the prevalence of and predictive factors associated with latent TB infection in adolescents.Adolescents aged 12-18 year

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::62ac14d12cc43db08ee8c0086bdbcb67
https://pubmed.ncbi.nlm.nih.gov/21333099