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Akademický článek

Multidisciplinary neurosurgical rounds incorporating antimicrobial stewardship. Are they of benefit?

Autor: M. Creedon, H. Humphreys, R. Connolly, L. Gaughan, M. Skally, J. Caird, J. Duddy, P.J. O'Halloran, T. Mandiwanza, K. Burns, B. Dinesh, E. Smyth, K. O'Connell, F. Fitzpatrick

Publikováno v: Brain and Spine, Vol 2, Iss , Pp 100885- (2022)

Background: In an era of increasing antimicrobial resistance, appropriate antimicrobials are essential to optimise patient outcomes. In 2017, antimicrobial use prevalence (AMU) on the two neurosurgical wards in our tertiary teaching hospital varied f

Externí odkaz: https://doaj.org/article/e0a3b53add9a41d094d7ba2afc00506f

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Akademický článek

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Akademický článek

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Pembrolizumab alone or with chemotherapy versus cetuximab with chemotherapy for recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-048): a randomised, open-label, phase 3 study

Autor: Burtness, B. Harrington, K.J. Greil, R. Soulières, D. Tahara, M. de Castro, G., Jr Psyrri, A. Basté, N. Neupane, P. Bratland, Å. Fuereder, T. Hughes, B.G.M. Mesía, R. Ngamphaiboon, N. Rordorf, T. Wan Ishak, W.Z. Hong, R.-L. González Mendoza, R. Roy, A. Zhang, Y. Gumuscu, B. Cheng, J.D. Jin, F. Rischin, D. Lerzo, G. Tatangelo, M. Varela, M. Zarba, J.J. Boyer, M. Gan, H. Gao, B. Hughes, B. Mallesara, G. Taylor, A. Burian, M. Barrios, C.H. de Castro Junior, D.O. Castro, G. Franke, F.A. Girotto, G. Lima, I.P.F. Nicolau, U.R. Pinto, G.D.J. Santos, L. Victorino, A.-P. Chua, N. Couture, F. Gregg, R. Hansen, A. Hilton, J. McCarthy, J. Soulieres, D. Ascui, R. Gonzalez, P. Villanueva, L. Torregroza, M. Zambrano, A. Holeckova, P. Kral, Z. Melichar, B. Prausova, J. Vosmik, M. Andersen, M. Gyldenkerne, N. Jurgens, H. Putnik, K. Reinikainen, P. Gruenwald, V. Laban, S. Aravantinos, G. Boukovinas, I. Georgoulias, V. Kwong, D. Al-Farhat, Y. Csoszi, T. Erfan, J. Horvai, G. Landherr, L. Remenar, E. Ruzsa, A. Szota, J. Billan, S. Gluck, I. Gutfeld, O. Popovtzer, A. Benasso, M. Bui, S. Ferrari, V. Licitra, L. Nole, F. Fujii, T. Fujimoto, Y. Hanai, N. Hara, H. Matsumoto, K. Mitsugi, K. Monden, N. Nakayama, M. Okami, K. Oridate, N. Shiga, K. Shimizu, Y. Sugasawa, M. Takahashi, M. Takahashi, S. Tanaka, K. Ueda, T. Yamaguchi, H. Yamazaki, T. Yasumatsu, R. Yokota, T. Yoshizaki, T. Kudaba, I. Stara, Z. Cheah, S.K. Aguilar Ponce, J. Gonzalez Mendoza, R. Hernandez Hernandez, C. Medina Soto, F. Buter, J. Hoeben, A. Oosting, S. Suijkerbuijk, K. Bratland, A. Brydoey, M. Alvarez, R. Mas, L. Caguioa, P. Querol, J. Regala, E.E. Tamayo, M.B. Villegas, E.M. Kawecki, A. Karpenko, A. Klochikhin, A. Smolin, A. Zarubenkov, O. Goh, B.C. Cohen, G. du Toit, J. Jordaan, C. Landers, G. Ruff, P. Szpak, W. Tabane, N. Brana, I. Iglesias Docampo, L. Lavernia, J. Mesia, R. Abel, E. Muratidu, V. Nielsen, N. Cristina, V. Rothschild, S. Wang, H.-M. Yang, M.-H. Yeh, S.-P. Yen, C.-J. Soparattanapaisarn, N. Sriuranpong, V. Aksoy, S. Cicin, I. Ekenel, M. Harputluoglu, H. Ozyilkan, O. Agarwala, S. Ali, H. Alter, R. Anderson, D. Bruce, J. Campbell, N. Conde, M. Deeken, J. Edenfield, W. Feldman, L. Gaughan, E. Goueli, B. Halmos, B. Hegde, U. Hunis, B. Jotte, R. Karnad, A. Khan, S. Laudi, N. Laux, D. Martincic, D. McCune, S. McGaughey, D. Misiukiewicz, K. Mulford, D. Nadler, E. Nunnink, J. Ohr, J. O'Malley, M. Patson, B. Paul, D. Popa, E. Powell, S. Redman, R. Rella, V. Rocha Lima, C. Sivapiragasam, A. Su, Y. Sukari, A. Wong, S. Yilmaz, E. Yorio, J.

Background: Pembrolizumab is active in head and neck squamous cell carcinoma (HNSCC), with programmed cell death ligand 1 (PD-L1) expression associated with improved response. Methods: KEYNOTE-048 was a randomised, phase 3 study of participants with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2127::25cb1f03a8d1b22885303ced3a20f10f
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3121788

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In Vivo and In Vitro Effects of Acrylamide on Synaptosomal Neurotransmitter Uptake and Release

Autor: Richard M. LoPachin, Christopher L. Gaughan, Soma Das, Shirley Mansukhani, Aron I Schwarcz

Publikováno v: NeuroToxicology. 25:349-363

Evidence suggests acrylamide (ACR) neurotoxicity is mediated by impaired presynaptic transmission. To assess the effects of ACR on nerve terminal function, [3H] glutamate release and uptake were determined in brain synaptosomes isolated from intoxica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e872a9783bc17cf5d44c08fb32e16fd4
https://doi.org/10.1016/s0161-813x(03)00149-9

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Experimental Spinal Cord Injury: Spatiotemporal Characterization of Elemental Concentrations and Water Contents in Axons and Neuroglia

Autor: Thomas M. Kelly, Christopher L. Gaughan, Richard M. LoPachin, Andrew R. Blight, Ellen J. Lehning, Yoshiro Kaneko

Publikováno v: Journal of Neurophysiology. 82:2143-2153

To examine the role of axonal ion deregulation in acute spinal cord injury (SCI), white matter strips from guinea pig spinal cord were incubated in vitro and were subjected to graded focal compression injury. At several postinjury times, spinal segme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7953aecb49035286741d39ee37c2a98a
https://doi.org/10.1152/jn.1999.82.5.2143

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The role of the HER2 and HER3 in prostate cancer and their potential as therapeutic targets

Autor: Craig N. Robson, K. Rao, L. Gaughan, Stuart McCracken

Publikováno v: European Journal of Cancer. 61:S177

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::811e1307420acf52ca3f358b7e5209cb
https://doi.org/10.1016/s0959-8049(16)61628-3

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Electron probe x-ray microanalysis: a quantitative electron microscopy technique for measurement of elements and water in nervous tissue cells

Autor: R M, Lopachin, C L, Gaughan

Publikováno v: Methods in molecular medicine. 22

Although structure and function of the major cells comprising nervous tissue have been studied extensively, very little detailed information exists concerning subcellular distributions of water and such elements as Na, K, Cl, and Ca. This information

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::098640303a528acc1dfc54a6371bc7b8
https://pubmed.ncbi.nlm.nih.gov/21380843

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