Zobrazeno 1 - 10
of 19
pro vyhledávání: '"L. G. Herbette"'
Publikováno v:
Journal of Medicinal Chemistry. 34:869-877
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e54327da2fdf3b8c708e33141bd1b8f0
https://doi.org/10.1021/jm00107a001
https://doi.org/10.1021/jm00107a001
Publikováno v:
Blood pressure. Supplement. 2
Calcium-channel antagonist drugs of the 1,4-dihydropyridine type have been shown to bind to the L-type calcium channel. These drugs are not only amphiphilic, but new molecular designs have become increasingly lipophilic and can readily transport acro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::71f83372a91ff16299f2715a372a5e2c
https://pubmed.ncbi.nlm.nih.gov/9850437
https://pubmed.ncbi.nlm.nih.gov/9850437
Publikováno v:
Improved Non-Steroid Anti-Inflammatory Drugs: COX-2 Enzyme Inhibitors ISBN: 9789401090315
Nonsteroid anti-inflammatory drugs (NSAIDs) are a structurally diverse group of agents with similar therapeutic effects. They reduce pain, fever and inflammation, and are also associated with lowered risks of cardiovascular disease1 and colon cancer2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76418a79b4bf2cd6a1360da562c6eaa7
https://doi.org/10.1007/978-94-010-9029-2_5
https://doi.org/10.1007/978-94-010-9029-2_5
Publikováno v:
Journal of cardiovascular pharmacology. 23
Membrane-active drugs can be characterized by direct measurements of their membrane partition coefficients, washout rates from membranes, and washin rates into membranes. There appears to be a correlation between the duration of action of such membra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::80ca29fd59c4b29e6889913a0ff0f2f1
https://pubmed.ncbi.nlm.nih.gov/7609501
https://pubmed.ncbi.nlm.nih.gov/7609501
Publikováno v:
Annals of the New York Academy of Sciences. 695
Small angle x-ray diffraction analysis of Alzheimer's disease (AD) lipid membranes reconstituted from cortical gray matter showed significant, reproducible structure changes relative to age-matched control samples.1 Specifically, there was an average
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::081dbae67eda19aec16d0b33d431beec
https://pubmed.ncbi.nlm.nih.gov/8239313
https://pubmed.ncbi.nlm.nih.gov/8239313
Publikováno v:
Drug design and delivery. 7(2)
In this review, the complex physical and chemical interactions of drugs with model and biological membranes under normal and pathological conditions are examined at the molecular level. The results of our own published and unpublished structural stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::066995ea2dd8381506ab8e20235be4ca
https://pubmed.ncbi.nlm.nih.gov/1910441
https://pubmed.ncbi.nlm.nih.gov/1910441
Publikováno v:
ChemInform. 21
Isopropyl 2-methoxyethyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3,5- pyridinedicarboxylate, C21H26N2O7, Mr = 418.45, orthorhombic, P2(1)2(1)2(1), a = 12.5897 (6), b = 14.6410 (9), c = 11.636 (1) A, V = 2144.8 (2) A3, Z = 4, Dm = 1.29, Dx = 1.30 g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::405c2ef2893ba2c4c5de097d75cda1ea
https://doi.org/10.1002/chin.199008041
https://doi.org/10.1002/chin.199008041
Publikováno v:
The Journal of membrane biology. 86(1)
The elastic X-ray/neutron diffraction techniques described in this review are currently capable of providing substantial information concerning the time-averaged structures and intermolecular ordering of molecular components within a dynamic membrane
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf8187a0add969e3381edfe0a8b09dbd
https://pubmed.ncbi.nlm.nih.gov/4046007
https://pubmed.ncbi.nlm.nih.gov/4046007
Publikováno v:
Acta crystallographica. Section C, Crystal structure communications. 45
Isopropyl 2-methoxyethyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3,5- pyridinedicarboxylate, C21H26N2O7, Mr = 418.45, orthorhombic, P2(1)2(1)2(1), a = 12.5897 (6), b = 14.6410 (9), c = 11.636 (1) A, V = 2144.8 (2) A3, Z = 4, Dm = 1.29, Dx = 1.30 g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32e389ecfe0767749d2100b2c97c2396
https://pubmed.ncbi.nlm.nih.gov/2610963
https://pubmed.ncbi.nlm.nih.gov/2610963
Autor:
S. M. Gruner, L. G. Herbette
Publikováno v:
Developments in Cardiovascular Medicine ISBN: 9781461292227
The precise nature of the interaction of amphiphilic1 substances, such as drugs, with native biological membranes is complex for a variety of reasons, not the least of which is the number of potential membrane sites. Certainly, small molecular substa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::356a78ea586bdd00049604ef67576a84
https://doi.org/10.1007/978-1-4613-2057-9_28
https://doi.org/10.1007/978-1-4613-2057-9_28