Zobrazeno 1 - 10
of 42
pro vyhledávání: '"L. G. Dring"'
Publikováno v:
Xenobiotica. 25:71-80
1. Male Sprague-Dawley rats given (RS)-[3H]-8-OHDPAT by intraperitoneal (i.p.) or intravenous (i.v.) injection, or orally (p.o.) by gavage, excreted the majority of the dose in the urine (80% in 3 days and70% in the first 24 h). A smaller proportion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a8b044e9ff38b18739d3ddcb4d04322
https://doi.org/10.3109/00498259509061834
https://doi.org/10.3109/00498259509061834
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 33:517-525
5′-[14C1]Panadiplon was prepared in 3 steps starting from [14C1]cyclopropane carboxylic acid and 3-(5′-cyano-1,2,4-oxadiazol-3-yl)-5-(1-methylethyl)-imidazo-[1,5a]-quinoxalin-4(5H)-one. 3a, 4-[13C2]Panadiplon was prepared in two steps from 13C2-o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ca9269a1ba649a4cfd234b4bd5a59fe
https://doi.org/10.1002/jlcr.2580330609
https://doi.org/10.1002/jlcr.2580330609
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 33:45-60
This paper describes the synthesis and characterisation of 2[[4-(2,6-di-1-pyrrolidinyl-4-pyrimidinyl)-1-piperazinyl]-[14C]- methyl]-3,4-dihydro-2,5,7,8-tetramethyl-2H-1-benzopyran-6-ol and 2[[4-(2,6-di-1-pyrrolidinyl-4-[13C2]-pyrimidinyl)-1- piperazi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd317d59829129387e97206408b53c7e
https://doi.org/10.1002/jlcr.2580330107
https://doi.org/10.1002/jlcr.2580330107
Publikováno v:
Xenobiotica. 22:963-971
1. Beagle dogs dosed orally with 14C-tazadolene succinate excreted much of the dose in the urine (mean 63.1% in 5 days with most excreted in the first 24 h). A lesser proportion of the dose was excreted in the faeces (mean 20.7%) and again most of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bffc7449df6ce959213526842602b26
https://doi.org/10.3109/00498259209049902
https://doi.org/10.3109/00498259209049902
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 29:909-918
The title compounds were synthesised in 7 steps from 1,7-dihydroxynaphthalene as follows: 1,7-dihydroxynaphthalene was methylated and subjected to a Birch reduction to yield 8-methoxy-2-tetralone. Reductive amination with sodium cyanoboro[3H]hydride
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c8a873e9047c1cd14d92e0fd2e9f05f
https://doi.org/10.1002/jlcr.2580290807
https://doi.org/10.1002/jlcr.2580290807
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 28:763-769
Three radiolabelled forms of trospectomycin (6′-n-propylspectinomycin sulphate hydrate) have been synthesised, namely [8′-14C]-, [6′,7′-3H]-, and [5′,6′,7′-3H]-trospectomycin. Although all three forms of the drug are metabolically stabl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a6349f3f05577b822da749bd67732cb6
https://doi.org/10.1002/jlcr.2580280705
https://doi.org/10.1002/jlcr.2580280705
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 25(12)
1. Plasma levels of 3H and unchanged drug were measured in the non-anaesthetized male rat after intravenous (i.v.) or oral administration of (+/-)-(R,S)-[propyl-3H]-8-OHD-PAT, at three dose levels per route of administration. The excretion of conjuga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f193fc82bad0fda038b4e7f777b6e46
https://pubmed.ncbi.nlm.nih.gov/8719911
https://pubmed.ncbi.nlm.nih.gov/8719911
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 19(4)
The pharmacokinetics and fate of [3H]trospectomycin sulfate, a novel aminocyclitol antibiotic, were examined in male and female dogs and rabbits. Total radioactivity levels in plasma were associated with unchanged trospectomycin in both dog and rabbi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::de6eb8e83349d0d8cdf8bd9e1e4757fe
https://pubmed.ncbi.nlm.nih.gov/1680655
https://pubmed.ncbi.nlm.nih.gov/1680655
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 18(5)
Trospectomycin sulfate is an experimental, aminocyclitol antibiotic. It has been shown in preclinical, chronic safety studies in the dog and rat to elicit a reversible, lysosomal phospholipidosis in liver. The present experiments were conducted to ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c457a173c16684e1f086ffca7e8a1482
https://pubmed.ncbi.nlm.nih.gov/1981727
https://pubmed.ncbi.nlm.nih.gov/1981727
Publikováno v:
Biochemical Pharmacology. 23:765-770
Publisher Summary This chapter elaborates the comparative metabolism of some amphetamines in various species. The β-hydroxylation of the benzene ring of the amphetamines is a reaction which occurs extensively and consistently in the rat but not to a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b355120926a43047a1f235e1dfef9aa9
https://doi.org/10.1016/0006-2952(74)90128-2
https://doi.org/10.1016/0006-2952(74)90128-2