Zobrazeno 1 - 10
of 45
pro vyhledávání: '"L. G. Darlington"'
Publikováno v:
Metabolic Brain Disease. 22:337-352
This review summarises the potential contributions of two groups of compounds to cerebral dysfunction and damage in metabolic disease. The kynurenines are oxidised metabolites of tryptophan, the kynurenine pathway being the major route for tryptophan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::587e2767b44c0d05793af00d7682bab1
https://doi.org/10.1007/s11011-007-9064-3
https://doi.org/10.1007/s11011-007-9064-3
Autor:
Trevor W. Stone, Lynn Oxford, Caroline M. Forrest, L. G. Darlington, Nicholas Stoy, G. Harman, Gillian M. Mackay
Publikováno v:
Nucleosides, Nucleotides and Nucleic Acids. 25:1287-1290
The anti-inflammatory activities of methotrexate and sulphasalazine may be mediated by increases in endogenous adenosine levels. Since the vascular protective drug dipyridamole inhibits the uptake and metabolism of adenosine we have now tested this c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4df6855d6d44d91027ed370753d5d7d5
https://doi.org/10.1080/15257770600890780
https://doi.org/10.1080/15257770600890780
Autor:
J. Christofides, L. G. Darlington, Gillian M. Mackay, Nicholas Stoy, Caroline M. Forrest, Trevor W. Stone, M. Egerton, M. Bridel
Publikováno v:
Journal of Neurochemistry. 97:1078-1088
Following a study of oxidative tryptophan metabolism to kynurenines, we have now analysed the blood of patients with either Huntington's disease or traumatic brain injury for levels of 5-hydroxytryptamine (5-HT), 5-hydroxyindoleacetic acid (5-HIAA) a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16a1701cfdd0b03a6d79169d0b6b25dc
https://doi.org/10.1111/j.1471-4159.2006.03807.x
https://doi.org/10.1111/j.1471-4159.2006.03807.x
Autor:
Trevor W. Stone, M. Egerton, L. G. Darlington, G. M. Mackay, Nicholas Stoy, J. Christofides, Caroline M. Forrest
Publikováno v:
European Journal of Neurology. 13:30-42
The kynurenine pathway generates the excitotoxic N-methyl-d-aspartate receptor agonist, quinolinic acid and the glutamate antagonist, kynurenic acid, as well as free-radical generators. We investigated the status of the pathway following severe brain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc5bac74653cebb2e27a487eedcc6574
https://doi.org/10.1111/j.1468-1331.2006.01220.x
https://doi.org/10.1111/j.1468-1331.2006.01220.x
Autor:
Nicholas Stoy, Trevor W. Stone, J. Christofides, C. M. Forrest, G. M. Mackay, M. Egerton, L. G. Darlington
Publikováno v:
Journal of Neurochemistry. 93:611-623
Abnormalities in the kynurenine pathway may play a role in Huntington's disease (HD). In this study, tryptophan depletion and loading were used to investigate changes in blood kynurenine pathway metabolites, as well as markers of inflammation and oxi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b59f7d9f413aefe7379a32b8479e2912
https://doi.org/10.1111/j.1471-4159.2005.03070.x
https://doi.org/10.1111/j.1471-4159.2005.03070.x
Autor:
Trevor W. Stone, Gillian M. Mackay, M. Egerton, Caroline M. Forrest, L. G. Darlington, J. Christofides, Nicholas Stoy
Publikováno v:
Free Radical Research. 38:1167-1171
In previous studies tryptophan loads have been administered to human subjects in order to raise central levels of 5-hydroxytryptamine (5HT) and assess the effects of 5HT on behaviour and mood. However, tryptophan is metabolised primarily along the ox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3d4974e72d00f62562700650b8196e6
https://doi.org/10.1080/10715760400011437
https://doi.org/10.1080/10715760400011437
Autor:
Trevor W. Stone, L. G. Darlington
Publikováno v:
Nature Reviews Drug Discovery. 1:609-620
At-a-glance The kynurenine pathway is the main pathway for tryptophan metabolism. It generates compounds that can modulate activity at glutamate receptors and possibly nicotinic receptors, in addition to some as-yet-unidentified sites. The pathway is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5759c77998d03f9c3b4dc645fc4b3a3
https://doi.org/10.1038/nrd870
https://doi.org/10.1038/nrd870
Autor:
Marina Snitcofsky, Mazura Pisar, Trevor W. Stone, Omari S. Khalil, L. G. Darlington, Kara McNair, Nélida N. Gonzalez, Edgar Kornisiuk, Caroline M. Forrest, Diana Jerusalinsky
During early brain development, N-methyl-D-aspartate (NMDA) receptors are involved in cell migration, neuritogenesis, axon guidance and synapse formation, but the mechanisms which regulate NMDA receptor density and function remain unclear. The kynure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbd9ab683ff7af6527f9c9dece249e5f
https://eprints.gla.ac.uk/87559/1/87559.pdf
https://eprints.gla.ac.uk/87559/1/87559.pdf
Publikováno v:
British Journal of Pharmacology. 128:1754-1760
1. There are differences between the excitotoxic actions of quinolinic acid and N-methyl-D-aspartate (NMDA) which suggest that quinolinic acid may act by mechanisms additional to the activation of NMDA receptors. The present study was designed to exa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f3eaeba52a3e77f4e92c8a10d9f7cb5a
https://doi.org/10.1038/sj.bjp.0702940
https://doi.org/10.1038/sj.bjp.0702940
Publikováno v:
Neuroscience. 231
The serine protease subtilisin-A produces a long-term depression (LTD) of synaptic potentials in hippocampal slices which differs mechanistically from classical LTD. Since caspases have been implicated in hippocampal plasticity, this study examined a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e747a0da89ff9f0913cee33d7bc0a2c3
https://pubmed.ncbi.nlm.nih.gov/23206873
https://pubmed.ncbi.nlm.nih.gov/23206873