Zobrazeno 1 - 10
of 28
pro vyhledávání: '"L. G. Brookes"'
Autor:
L. G. Brookes
When we first contemplated a book on this subject we were faced with a number of options: (a) to write it all ourselves, which would have had the merit of internal consistency and continuity of style; (b) to produce a collection of existing papers. w
Autor:
Nancy C. Sambol, Janie Chiang, A. M. Goodman, Leslie Z. Benet, Chui Y. Liu, Emil T. Lin, L. G. Brookes
Publikováno v:
British Journal of Clinical Pharmacology. 42:510-512
The pharmacokinetics of four single-dose treatments of the metformin administered orally (as the HCl salt) were compared in 24 healthy subjects: 500 mg and 850 mg tablets and 850 mg solution fasting and 850 mg tablet with food. Solution and tablet fo
Publikováno v:
British journal of clinical pharmacology. 42(4)
The pharmacokinetics of four single-dose treatments of the metformin administered orally (as the HCl salt) were compared in 24 healthy subjects: 500 mg and 850 mg tablets and 850 mg solution fasting and 850 mg tablet with food. Solution and tablet fo
Publikováno v:
Journal of Pharmacy and Pharmacology. 31:277-283
The actions of anionic, cationic and non-ionic surfactants on the absorptive capability of rat jejunal tissue in vivo were compared with their effects on the amounts of protein and phospholipid released from the mucosal surface under the same conditi
Autor:
L. G. Brookes
Publikováno v:
R&D Management. 4:127-134
The pay-off from a new power system does not begin to accrue until many years after the initial research; and perhaps not until 10 years or more after major development programmes are launched. The ensuing benefit to the community in terms of reduced
Publikováno v:
Journal of Pharmacy and Pharmacology. 24:281-288
The urinary excretion of N-(2-benzoyloxyethyl)norfenfluramine (JP 992) was examined in man with normal and acidic urine after oral administration of the drug; 86–100% of the dose was excreted in 48 h as metabolites of the drug having m-trifluoromet
Publikováno v:
Journal of Pharmacy and Pharmacology. 21:151S-156S
The urinary excretion of ethylamphetamine and its metabolite amphetamine was studied in man after oral administration of (±)-, (+)-, and (-)-ethylamphetamine hydrochloride. The rates of excretion of these amines are dependant on the pH of the urine.
Autor:
A. H. Beckett, L. G. Brookes
Publikováno v:
Journal of Pharmacy and Pharmacology. 23:837-841
Two or more related drugs of the amphetamine class were simultaneously administered to man under acidic urine control, their urinary excretion being examined by gas-liquid chromatography. This was shown to be a suitable procedure for determining the
Publikováno v:
Journal of Pharmacy and Pharmacology. 31:734-736
Serum concentrations of drug were obtained at various times after intramuscular dosing of healthy mice with either clindamycin or lincomycin hydrochlorides. Washings from the peritoneal cavity were taken at the same time as the serum samples. Changes
Publikováno v:
Journal of Pharmacy and Pharmacology. 23:705-707