Polygenic risk of paclitaxel-induced peripheral neuropathy: a genome-wide association study

Autor: Kosar Hooshmand, David Goldstein, Hannah C. Timmins, Tiffany Li, Michelle Harrison, Michael L. Friedlander, Craig R. Lewis, Justin G. Lees, Gila Moalem-Taylor, Boris Guennewig, Susanna B. Park, John B. Kwok

Publikováno v: Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-12 (2022)

Abstract Background Genetic risk factors for chemotherapy-induced peripheral neuropathy (CIPN), a major dose-limiting side-effect of paclitaxel, are not well understood. Methods We performed a genome-wide association study (GWAS) in 183 paclitaxel-tr

Externí odkaz: https://doaj.org/article/2c68d9d7c95a4ee5840e68ef1badc7f5

Regular use of aspirin and other non-steroidal anti-inflammatory drugs and breast cancer risk for women at familial or genetic risk: a cohort study

Autor: Rebecca D. Kehm, John L. Hopper, Esther M. John, Kelly-Anne Phillips, Robert J. MacInnis, Gillian S. Dite, Roger L. Milne, Yuyan Liao, Nur Zeinomar, Julia A. Knight, Melissa C. Southey, Linda Vahdat, Naomi Kornhauser, Tessa Cigler, Wendy K. Chung, Graham G. Giles, Sue-Anne McLachlan, Michael L. Friedlander, Prue C. Weideman, Gord Glendon, Stephanie Nesci, kConFab Investigators, Irene L. Andrulis, Saundra S. Buys, Mary B. Daly, Mary Beth Terry

Publikováno v: Breast Cancer Research, Vol 21, Iss 1, Pp 1-13 (2019)

Abstract Background The use of aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) has been associated with reduced breast cancer risk, but it is not known if this association extends to women at familial or genetic risk. We examined the

Externí odkaz: https://doaj.org/article/5da6d9e843624b0697b2e4db6ae0cbf5

Profiling the immune landscape in mucinous ovarian carcinoma

Autor: Nicola S. Meagher, Phineas Hamilton, Katy Milne, Shelby Thornton, Bronwyn Harris, Ashley Weir, Jennifer Alsop, Christiani Bisinoto, James D. Brenton, Angela Brooks-Wilson, Derek S. Chiu, Kara L. Cushing-Haugen, Sian Fereday, Dale W. Garsed, Simon A. Gayther, Aleksandra Gentry-Maharaj, Blake Gilks, Mercedes Jimenez-Linan, Catherine J. Kennedy, Nhu D. Le, Anna M. Piskorz, Marjorie J. Riggan, Mitul Shah, Naveena Singh, Aline Talhouk, Martin Widschwendter, David D.L. Bowtell, Francisco J. Candido dos Reis, Linda S. Cook, Renée T. Fortner, María J. García, Holly R. Harris, David G. Huntsman, Anthony N. Karnezis, Martin Köbel, Usha Menon, Paul D.P. Pharoah, Jennifer A. Doherty, Michael S. Anglesio, Malcolm C. Pike, Celeste Leigh Pearce, Michael L. Friedlander, Anna DeFazio, Brad H. Nelson, Susan J. Ramus

Publikováno v: Gynecologic Oncology. 168:23-31

Mucinous ovarian carcinoma (MOC) is a rare histotype of ovarian cancer, with low response rates to standard chemotherapy, and very poor survival for patients diagnosed at advanced stage. There is a limited understanding of the MOC immune landscape, a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8232bd6bc8a4de1eb0f10e0e21d4e388
https://doi.org/10.1016/j.ygyno.2022.10.022

Nonepithelial Ovarian Malignancies

Autor: Jonathan S. Berek, Malte Renz, Michael L. Friedlander, Robert C. Bast

Publikováno v: Holland‐Frei Cancer Medicine. :1-18

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dd70bf7208db1dc227991fb75859e718
https://doi.org/10.1002/9781119000822.hfcm106.pub2

Gene-Expression Profiling of Mucinous Ovarian Tumors and Comparison with Upper and Lower Gastrointestinal Tumors Identifies Markers Associated with Adverse Outcomes

Autor: Nicola S, Meagher, Kylie L, Gorringe, Matthew, Wakefield, Adelyn, Bolithon, Chi Nam Ignatius, Pang, Derek S, Chiu, Michael S, Anglesio, Kylie-Ann, Mallitt, Jennifer A, Doherty, Holly R, Harris, Joellen M, Schildkraut, Andrew, Berchuck, Kara L, Cushing-Haugen, Ksenia, Chezar, Angela, Chou, Adeline, Tan, Jennifer, Alsop, Ellen, Barlow, Matthias W, Beckmann, Jessica, Boros, David D L, Bowtell, Alison H, Brand, James D, Brenton, Ian, Campbell, Dane, Cheasley, Joshua, Cohen, Cezary, Cybulski, Esther, Elishaev, Ramona, Erber, Rhonda, Farrell, Anna, Fischer, Zhuxuan, Fu, Blake, Gilks, Anthony J, Gill, Charlie, Gourley, Marcel, Grube, Paul R, Harnett, Arndt, Hartmann, Anusha, Hettiaratchi, Claus K, Høgdall, Tomasz, Huzarski, Anna, Jakubowska, Mercedes, Jimenez-Linan, Catherine J, Kennedy, Byoung-Gie, Kim, Jae-Weon, Kim, Jae-Hoon, Kim, Kayla, Klett, Jennifer M, Koziak, Tiffany, Lai, Angela, Laslavic, Jenny, Lester, Yee, Leung, Na, Li, Winston, Liauw, Belle W X, Lim, Anna, Linder, Jan, Lubiński, Sakshi, Mahale, Constantina, Mateoiu, Simone, McInerny, Janusz, Menkiszak, Parham, Minoo, Suzana, Mittelstadt, David, Morris, Sandra, Orsulic, Sang-Yoon, Park, Celeste Leigh, Pearce, John V, Pearson, Malcolm C, Pike, Carmel M, Quinn, Ganendra Raj, Mohan, Jianyu, Rao, Marjorie J, Riggan, Matthias, Ruebner, Stuart, Salfinger, Clare L, Scott, Mitul, Shah, Helen, Steed, Colin J R, Stewart, Deepak, Subramanian, Soseul, Sung, Katrina, Tang, Paul, Timpson, Robyn L, Ward, Rebekka, Wiedenhoefer, Heather, Thorne, Paul A, Cohen, Philip, Crowe, Peter A, Fasching, Jacek, Gronwald, Nicholas J, Hawkins, Estrid, Høgdall, David G, Huntsman, Paul A, James, Beth Y, Karlan, Linda E, Kelemen, Stefan, Kommoss, Gottfried E, Konecny, Francesmary, Modugno, Sue K, Park, Annette, Staebler, Karin, Sundfeldt, Anna H, Wu, Aline, Talhouk, Paul D P, Pharoah, Lyndal, Anderson, Anna, DeFazio, Martin, Köbel, Michael L, Friedlander, Susan J, Ramus

Publikováno v: Meagher, N S, Gorringe, K L, Wakefield, M J, Bolithon, A, Pang, C N I, Chiu, D S, Anglesio, M S, Mallitt, K, Doherty, J A, Harris, H R, Schildkraut, J M, Berchuck, A, Cushing-haugen, K L, Chezar, K, Chou, A, Tan, A, Alsop, J, Barlow, E, Beckmann, M W, Boros, J, Bowtell, D D, Brand, A H, Brenton, J D, Campbell, I, Cheasley, D, Cohen, J, Cybulski, C, Elishaev, E, Erber, R, Farrell, R, Fischer, A, Fu, Z, Gilks, B, Gill, A J, Gourley, C, Grube, M, Harnett, P, Hartmann, A, Hettiaratchi, A, Høgdall, C K, Huzarski, T, Jakubowska, A, Jimenez-linan, M, Kennedy, C J, Kim, B, Kim, J, Kim, J, Klett, K, Koziak, J, Lai, T, Laslavic, A, Lester, J, Leung, Y, Li, N, Liauw, W, Lim, B W X, Linder, A, Lubinski, J, Mahale, S, Mateoiu, C, Mcinerny, S, Menkiszak, J, Minoo, P, Mittelstadt, S, Morris, D, Orsulic, S, Park, S Y, Pearce, C L, Pearson, J V, Pike, M C, Quinn, C M, Mohan, G R, Rao, J, Riggan, M J, Ruebner, M, Salfinger, S, Scott, C L, Shah, M, Steed, H, Stewart, C J R, Subramanian, D, Sung, S, Tang, K, Timpson, P, Ward, R L, Wiedenhoefer, R, Thorne, H, Cohen, P A, Crowe, P, Fasching, P A, Gronwald, J, Hawkins, N J, Høgdall, E, Huntsman, D G, James, P A, Karlan, B Y, Kelemen, L E, Kommoss, S, Konecny, G E, Modugno, F, Park, S K, Staebler, A, Sundfeldt, K, Wu, A H, Talhouk, A, Pharoah, P D P, Anderson, L, Defazio, A, Köbel, M, Friedlander, M L & Ramus, S J 2022, ' Gene expression profiling of mucinous ovarian tumors and comparison with upper and lower gastrointestinal tumors identifies markers associated with adverse outcomes. ', Clinical Cancer Research . https://doi.org/10.1158/1078-0432.CCR-22-1206, https://doi.org/10.1158/1078-0432.CCR-22-1206
AOCS Grp, Australian Pancreatic Genome Initi & kConFab Investigators 2022, ' Gene-Expression Profiling of Mucinous Ovarian Tumors and Comparison with Upper and Lower Gastrointestinal Tumors Identifies Markers Associated with Adverse Outcomes ', Clinical Cancer Research, vol. 28, no. 24, pp. 5383-5395 . https://doi.org/10.1158/1078-0432.CCR-22-1206

Purpose: Advanced-stage mucinous ovarian carcinoma (MOC) has poor chemotherapy response and prognosis and lacks biomarkers to aid stage I adjuvant treatment. Differentiating primary MOC from gastrointestinal (GI) metastases to the ovary is also chall

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68e7e60454f3d65c0cafb4f51f254763
https://doi.org/10.1158/1078-0432.ccr-22-1206