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Evidence for epsilon-opioid receptor-mediated beta-endorphin-induced analgesia

Autor: L F, Tseng

Publikováno v: Trends in pharmacological sciences. 22(12)

Among the opioid receptors, which have been pharmacologically classified as mu, delta, kappa and epsilon, the existence of the epsilon receptor has been controversial, and this receptor is generally not recognized as a member of the opioid peptide re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e62473b811bb92708741ccdd63695d94
https://pubmed.ncbi.nlm.nih.gov/11730972

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Acute antinociceptive tolerance and asymmetric cross-tolerance between endomorphin-1 and endomorphin-2 given intracerebroventricularly in the mouse

Autor: H E, Wu, K C, Hung, H, Mizoguchi, J M, Fujimoto, L F, Tseng

Publikováno v: The Journal of pharmacology and experimental therapeutics. 299(3)

Development of tolerance in mice pretreated intracerebroventricularly with mu-opioid receptor agonist endomorphin-1, endomorphin-2, or [D-Ala(2),N-Me-Phe(4),Gly-ol(5)]-enkephalin (DAMGO) was compared between endomorphin-1- and endomorphin-2-induced a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::83d6907802583eebe4127951c2729df7
https://pubmed.ncbi.nlm.nih.gov/11714902

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Differential antinociception induced by spinally administered endomorphin-1 and endomorphin-2 in the mouse

Autor: M, Ohsawa, H, Mizoguchi, M, Narita, H, Nagase, J P, Kampine, L F, Tseng

Publikováno v: The Journal of pharmacology and experimental therapeutics. 298(2)

We have previously demonstrated that the antinociception induced by either endomorphin-1 or endomorphin-2 given supraspinally is mediated by the stimulation of mu-opioid receptors. However, the antinociception induced by endomorphin-2 given supraspin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7cdd9fc5460d28bcacb2cb9c4fa99b0a
https://pubmed.ncbi.nlm.nih.gov/11454920

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Inverse agonist action of Leu-enkephalin at delta(2)-opioid receptors mediates spinal antianalgesia

Autor: J J, Rady, B B, Holmes, L F, Tseng, J M, Fujimoto

Publikováno v: The Journal of pharmacology and experimental therapeutics. 297(2)

Dynorphin A(1-17) given intrathecally releases spinal cholecystokinin to produce an antianalgesic action against spinal morphine in the tail-flick test in CD-1 mice. The present study showed that following the cholecystokinin step, a delta(2)-opioid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::618aba84ccd5f667a728779cb7e828d3
https://pubmed.ncbi.nlm.nih.gov/11303046

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Differential mechanisms mediating descending pain controls for antinociception induced by supraspinally administered endomorphin-1 and endomorphin-2 in the mouse

Autor: M, Ohsawa, H, Mizoguchi, M, Narita, M, Chu, H, Nagase, L F, Tseng

Publikováno v: The Journal of pharmacology and experimental therapeutics. 294(3)

We have previously demonstrated that both endomorphin-1 and endomorphin-2 produce their antinociception by the stimulation of mu-opioid receptors. However, the antinociception induced by endomorphin-2 contains an additional component, which is mediat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2dc5117615b51e4ab40d9f79c35e8588
https://pubmed.ncbi.nlm.nih.gov/10945866

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Characterization of endomorphin-1 and -2 on [35S]GTPgammaS binding in the mouse spinal cord

Autor: M, Narita, H, Mizoguchi, G S, Oji, E L, Tseng, C, Suganuma, H, Nagase, L F, Tseng

Publikováno v: European journal of pharmacology. 351(3)

In the present study, G-protein activation by newly-isolated opioid peptides, endomorphin-1 and -2, was examined in the mouse spinal cord by monitoring the binding of the non-hydrolyzable analog of GTP, guanosine-5'-O-(3-[35S]thio)triphosphate ([35S]

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::759bedaaead45ae9eff6f001fa4f2660
https://pubmed.ncbi.nlm.nih.gov/9721032

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Evidence for the existence of the beta-endorphin-sensitive 'epsilon-opioid receptor' in the brain: the mechanisms of epsilon-mediated antinociception

Autor: M, Narita, L F, Tseng

Publikováno v: Japanese journal of pharmacology. 76(3)

Recently, mu-, delta- and kappa-opioid receptors have been cloned and relatively well-characterized. In addition to three major opioid receptor types, more extensive studies have suggested the possible existence of other opioid receptor types that ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::325aa2bc973733731aebda4f0982dc1f
https://pubmed.ncbi.nlm.nih.gov/9593217

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