Zobrazeno 1 - 10
of 33
pro vyhledávání: '"L. F. Sancilio"'
Autor:
Joseph J. DeGeorge, L. F. Sancilio, M. E. Brower, C. J. Sun, Wendelyn J. Schmidt, S. Williams, W. D. Mcguinn, V. Whitehurst, P. A. Andrews, H. V. Sheevers, Doo Young Lee-Ham, Alan S. Taylor, Chang Ho Ahn, L. Pei, M. Y. Chun, S C Tripathi, T. Du, Y. S. Choi, W. M. Vogel
Publikováno v:
Regulatory Toxicology and Pharmacology. 25:189-193
The standard approaches for the preclinical development of chronically administered drugs also apply to most respiratory drugs. Modifications from the standard preclinical development plan, however, may be necessary if the drug is administered intran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39e2d598b3313edcc146b8815d0b8d8a
https://doi.org/10.1006/rtph.1997.1099
https://doi.org/10.1006/rtph.1997.1099
Autor:
Joseph C. Nolan, David A. Walsh, L. F. Sancilio, W. J. Jun. Welstead, Gustav Graff, Dwight A. Shamblee, Henry W. Moran
Publikováno v:
ChemInform. 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6dc6d9468268fc2770e6540897703663
https://doi.org/10.1002/chin.199105178
https://doi.org/10.1002/chin.199105178
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 261(2)
8-Methoxy-4-[(2-isopropylphenyl)amino]-3-quinolinecarboxylate ethyl ester (AHR-9294) inhibited acid secretion stimulated by histamine, pentagastrin or carbachol in rats, and by histamine or feeding in dogs. AHR-9294 was about half as potent as omepra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7444f21540850d9a733a109696693391
https://pubmed.ncbi.nlm.nih.gov/1315865
https://pubmed.ncbi.nlm.nih.gov/1315865
Autor:
M Foxwell, C H Radvany, G Graff, David A. Walsh, L Whitman, L. F. Sancilio, C E Gathright, Y Lo, J C Nolan
Publikováno v:
The Journal of pharmacy and pharmacology. 42(8)
AHR-15010 (3-(2-methoxyphenoxy)-1,2-propanediol bissulphamate ester) is a compound of novel structure that displays anti-arthritic activity in adjuvant arthritis in rats. When given orally from days 18 through day 50, (excluding weekends) after adjuv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94fc46ccdda5aada99d93e354c1e9522
https://pubmed.ncbi.nlm.nih.gov/1981578
https://pubmed.ncbi.nlm.nih.gov/1981578
Autor:
Joseph C. Nolan, Dwight A. Shamblee, Gustav Graff, Moran Hw, L. F. Sancilio, David A. Walsh, William J. Welstead
Publikováno v:
Journal of medicinal chemistry. 33(8)
A series of potential prodrugs of 2-amino-3-benzoylbenzeneacetic acid (amfenac) and 2-amino-3-(4-chlorobenzoyl) benzeneacetic acid were synthesized and evaluated for their cyclooxygenase inhibiting properties, antiinflammatory potency, and gastrointe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33d71330cab2a4d40d0f4c98daed910d
https://pubmed.ncbi.nlm.nih.gov/2115589
https://pubmed.ncbi.nlm.nih.gov/2115589
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 254(1)
Bromfenac [2-amino-3-(4-bromobenzoyl)benzenacetic acid, sodium salt sesquihydrate] exhibited potent analgesic and anti-inflammatory activity in mice and rats. In a mouse model of pain (acetylcholine abdominal constriction), bromfenac showed a rapid o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7b22f729a6473dbfaef4abe2181590cb
https://pubmed.ncbi.nlm.nih.gov/2366177
https://pubmed.ncbi.nlm.nih.gov/2366177
Publikováno v:
Journal of Medicinal Chemistry. 17:544-547
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7a21318b8b0ebac51ea6e8b8287710a
https://doi.org/10.1021/jm00251a019
https://doi.org/10.1021/jm00251a019
Publikováno v:
Journal of Medicinal Chemistry. 27:1317-1321
A series of N-(2-benzoylphenyl)alanine derivatives were synthesized and tested for antiinflammatory activity in the Evans blue-carrageenan induced pleural effusion assay. The target compounds were envisioned to bind to a receptor site on the cyclooxy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba77c89b5c4770f7ae110abda1322d76
https://doi.org/10.1021/jm00376a016
https://doi.org/10.1021/jm00376a016
Publikováno v:
Journal of Medicinal Chemistry. 17:45-48
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca8603a3c4a368dfbafb696872f7e0f6
https://doi.org/10.1021/jm00247a010
https://doi.org/10.1021/jm00247a010
Publikováno v:
Agents and Actions. 25:77-85
Bromfenac [2-amino-3-(4-bromobenzoyl)benzeneacetic acid sodium salt sesquihydrate] is an anti-inflammatory/analgesic agent that possesses potent topical activity in rats, guinea pigs, and mice. In rat models of acute (carrageenan paw edema) and chron
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79ee4b49f097ca931a741197a9dc6cef
https://doi.org/10.1007/bf01969098
https://doi.org/10.1007/bf01969098