Výsledky vyhledávání - "L. F. Larsen"

Preclinical pharmacokinetics and biodistribution of subcutaneously administered glycoPEGylated recombinant factor VIII (N8-GP) and development of a human pharmacokinetic prediction model

Autor: Mads Kreilgaard, Peter B. Johansen, Jesper Haaning, Frederik Rode, L. F. Larsen, Mette Loftager, K. Almholt, Maj Petersen, Marianne Kjalke, D. M. Karpf, Andreas Velsing Groth

Publikováno v: Journal of thrombosis and haemostasis : JTH. 16(6)

Essentials N8-GP is an extended half-life recombinant factor VIII (FVIII) for the treatment of hemophilia A. Subcutaneous (SC) FVIII dosing might reduce the treatment burden of prophylaxis. SC N8-GP has a favorable PK profile in animal models and dis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52535d6af3770733e2993fb3cc33722c
https://pubmed.ncbi.nlm.nih.gov/29582559

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Adipose tissue lipin expression levels distinguish HIV patients with and without lipodystrophy

Autor: L. F. Larsen, Karen Reue, Birgitte Lindegaard, Bente Klarlund Pedersen, Jan Gerstoft, A.-B. E. Hansen

Publikováno v: International journal of obesity (2005). 31(3)

Lipodystrophy is the major complication of antiretroviral therapy in HIV-infected patients. Its pathophysiology is not well understood, but has been linked to antiadipogenic effects of antiretroviral drugs. Lipin represents a newly characterized prot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0a51abbb84256efda01adc050851b54
https://pubmed.ncbi.nlm.nih.gov/16847472

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The Göttingen minipig as a model for postprandial hyperlipidaemia in man: experimental observations

Autor: L. F. Larsen, P. Marckmann, Else M. Bladbjerg, Axel Kornerup Hansen, Aage Kristian Olsen

Publikováno v: Olsen, A K, Bladbjerg, E-M, Marckmann, P, Larsen, L F & Hansen, A K 2002, ' The Göttingen minipig as a model for postprandial hyperlipidaemia in man: experimental observations. ', Laboratory Animals. Journal of the Laboratory Animal Science Association, vol. 36, no. 4, pp. 438-444 . https://doi.org/10.1258/002367702320389116

Postprandial hyperlipidaemia is believed to be atherogenic. This study aimed to establish a minipig model to investigate determinants of postprandial lipid metabolism. In a randomized cross-over design seven minipigs were subjected to six different f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::653099caa6921aed91078324c5797c8a
https://portal.findresearcher.sdu.dk/da/publications/419ae540-eb7a-11dc-86ef-000ea68e967b

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Stimulation of glioma-cell migration by laminin and inhibition by anti-alpha3 and anti-beta1 integrin antibodies

Autor: B B, Tysnes, L F, Larsen, G O, Ness, R, Mahesparan, K, Edvardsen, I, Garcia-Cabrera, R, Bjerkvig

Publikováno v: International journal of cancer. 67(6)

An induction of laminin in the confrontation zone between tumor cells and normal brain tissue has been observed in our model systems in vivo and in vitro. In order to study the effects of ECM components on glioma-cell migration and invasion, we have

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ab1b5e8852fadff1e8a69f93a3b08b95
https://pubmed.ncbi.nlm.nih.gov/8824548

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