Zobrazeno 1 - 10
of 269
pro vyhledávání: '"L. F. JOHNSON"'
Publikováno v:
mSystems, Vol 9, Iss 12 (2024)
ABSTRACT CRISPR-Cas is the only known adaptive immune system of prokaryotes. It is a powerful defense system against mobile genetic elements such as bacteriophages. While CRISPR-Cas systems can be found throughout the prokaryotic tree of life, they a
Externí odkaz:
https://doaj.org/article/d7a5edbe690b47b0a185ad1066516651
Autor:
Jake L. Weissman, Sonia Dogra, Keyan Javadi, Samantha Bolten, Rachel Flint, Cyrus Davati, Jess Beattie, Keshav Dixit, Tejasvi Peesay, Shehar Awan, Peter Thielen, Florian Breitwieser, Philip L. F. Johnson, David Karig, William F. Fagan, Sharon Bewick
Publikováno v:
BMC Bioinformatics, Vol 22, Iss 1, Pp 1-21 (2021)
Abstract Background Even when microbial communities vary wildly in their taxonomic composition, their functional composition is often surprisingly stable. This suggests that a functional perspective could provide much deeper insight into the principl
Externí odkaz:
https://doaj.org/article/6cfa8c060bc5420abcdfb73f982b6f09
Autor:
Veronika I Zarnitsyna, Rama S Akondy, Hasan Ahmed, Donald J McGuire, Vladimir G Zarnitsyn, Mia Moore, Philip L F Johnson, Rafi Ahmed, Kelvin W Li, Marc K Hellerstein, Rustom Antia
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 10, p e1009468 (2021)
Understanding how immunological memory lasts a lifetime requires quantifying changes in the number of memory cells as well as how their division and death rates change over time. We address these questions by using a statistically powerful mixed-effe
Externí odkaz:
https://doaj.org/article/d833a13fe7e34b38b5d1e8330ab10a2f
Autor:
J. L. Weissman, Philip L. F. Johnson
Publikováno v:
mSystems, Vol 5, Iss 1 (2020)
ABSTRACT A diversity of clustered regularly interspaced short palindromic repeat (CRISPR)-Cas systems provide adaptive immunity to bacteria and archaea through recording “memories” of past viral infections. Recently, many novel CRISPR-associated
Externí odkaz:
https://doaj.org/article/fc1e5430a6f74a99a049cd59995f88d8
Publikováno v:
PLoS Genetics, Vol 15, Iss 11, p e1008493 (2019)
Genomic GC content varies widely among microbes for reasons unknown. While mutation bias partially explains this variation, prokaryotes near-universally have a higher GC content than predicted solely by this bias. Debate surrounds the relative import
Externí odkaz:
https://doaj.org/article/db7d7ce9e9244a698d1d4f55535261d6
Autor:
Philip L F Johnson, Carl T Bergstrom, Roland R Regoes, Ira M Longini, M Elizabeth Halloran, Rustom Antia
Publikováno v:
The Lancet. 400:1191-1193
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5fd1d66804e175758facce031c3714d5
https://doi.org/10.1016/s0140-6736(22)01789-5
https://doi.org/10.1016/s0140-6736(22)01789-5
Birds of the order Passeriformes represent the most speciose radiation of land vertebrates, yet the cause or causes of their elevated species richness have not been satisfactorily explained. One potential key adaptation is their sole lineage-specific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8057d8e2ff5a8592ec5f51ea75680ce9
https://doi.org/10.1101/2022.07.29.502092
https://doi.org/10.1101/2022.07.29.502092
Provincial differences in infant deaths in South Africa – an effect of antiretroviral interventions?
Autor:
A Boulle, M L Thompson, R Laubscher, L F Johnson, R Sayed, L L Brody, B Draper, M F Cotton, F Abdullah, J E Myers, D E Bourne
Publikováno v:
Southern African Journal of HIV Medicine, Vol 12, Iss 1, Pp 20-23 (2011)
Original article
Externí odkaz:
https://doaj.org/article/ac72132f4cd1416ea9638c93bba0264d
Publikováno v:
The ISME Journal
Bacteria and archaea are locked in a near-constant battle with their viral pathogens. Despite previous mechanistic characterization of numerous prokaryotic defense strategies, the underlying ecological drivers of different strategies remain largely u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87bd92d95780c249617517c56d9576ad
https://doi.org/10.1038/s41396-019-0411-2
https://doi.org/10.1038/s41396-019-0411-2